2014
DOI: 10.18632/aging.100691
View full text |Buy / Rent full text
|
Sign up to set email alerts
|

Abstract: Aging is associated with common conditions, including cancer, diabetes, cardiovascular disease, and Alzheimer's disease. The type of multi-targeted pharmacological approach necessary to address a complex multifaceteddisease such as aging might take advantage of pleiotropic natural polyphenols affecting a wide variety of biological processes. We have recently postulated that the secoiridoids oleuropein aglycone (OA) and decarboxymethyl oleuropein aglycone (DOA), two complex polyphenols present in health-promoti… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

1
17
0

Year Published

2016
2016
2018
2018

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 24 publications
(32 citation statements)
references
References 44 publications
(32 reference statements)
1
17
0
Order By: Relevance
“…Research on mitochondriotropic antioxidants has been increasing over the last years. One viable and promising strategy involves the use of dietary polyphenolic antioxidants templates along with the chemical modulation of their properties, including mitochondrial targeting ability, efficacy, and toxicity 25 . In this context, some mitochondria-targeted polyphenolic-based molecules have been developed including MitoResveratrol, MitoCurcumin, and MitoQuercetin 26–28 .…”
Section: Resultsmentioning
confidence: 99%
“…Research on mitochondriotropic antioxidants has been increasing over the last years. One viable and promising strategy involves the use of dietary polyphenolic antioxidants templates along with the chemical modulation of their properties, including mitochondrial targeting ability, efficacy, and toxicity 25 . In this context, some mitochondria-targeted polyphenolic-based molecules have been developed including MitoResveratrol, MitoCurcumin, and MitoQuercetin 26–28 .…”
Section: Resultsmentioning
confidence: 99%
“…Although molecular dynamics and Austin Model 1 (AM1) level computational mapping of oleuropein have been developed, the downstream mechanisms are not fully understood [ 16 , 17 ]. This is one of the drawbacks of important bioavailable olive BPsecos, their concentration present in olive products, and their biomolecular structures [ 34 ]. Acid-catalyzed oleuropein downstream pathways, however, could evolve via dynamic pre-equilibrium to oleuropein + H + isomers ( Figure 1 ).…”
Section: Introductionmentioning
confidence: 99%
“…Improved prediction of drug performance prior to lengthy experimentation would cut waste [ 21 , 22 ]. Vast datasets now exist that enable such prediction with the help of sophisticated computational methods [ 23 , 24 ]. Two particularly valuable datasets in this respect are the literally millions of gene expression profiles stored in repositories such as GEO [ 25 , 26 ] and a number of increasingly diverse compound screening libraries [ 27 ].…”
Section: Introductionmentioning
confidence: 99%