2014
DOI: 10.18632/aging.100691
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Abstract: Aging is associated with common conditions, including cancer, diabetes, cardiovascular disease, and Alzheimer's disease. The type of multi-targeted pharmacological approach necessary to address a complex multifaceteddisease such as aging might take advantage of pleiotropic natural polyphenols affecting a wide variety of biological processes. We have recently postulated that the secoiridoids oleuropein aglycone (OA) and decarboxymethyl oleuropein aglycone (DOA), two complex polyphenols present in health-promoti… Show more

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Cited by 26 publications
(19 citation statements)
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References 44 publications
(32 reference statements)
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“…Research on mitochondriotropic antioxidants has been increasing over the last years. One viable and promising strategy involves the use of dietary polyphenolic antioxidants templates along with the chemical modulation of their properties, including mitochondrial targeting ability, efficacy, and toxicity 25 . In this context, some mitochondria-targeted polyphenolic-based molecules have been developed including MitoResveratrol, MitoCurcumin, and MitoQuercetin 26–28 .…”
Section: Resultsmentioning
confidence: 99%
“…Although molecular dynamics and Austin Model 1 (AM1) level computational mapping of oleuropein have been developed, the downstream mechanisms are not fully understood [ 16 , 17 ]. This is one of the drawbacks of important bioavailable olive BPsecos, their concentration present in olive products, and their biomolecular structures [ 34 ]. Acid-catalyzed oleuropein downstream pathways, however, could evolve via dynamic pre-equilibrium to oleuropein + H + isomers ( Figure 1 ).…”
Section: Introductionmentioning
confidence: 99%
“…Improved prediction of drug performance prior to lengthy experimentation would cut waste [ 21 , 22 ]. Vast datasets now exist that enable such prediction with the help of sophisticated computational methods [ 23 , 24 ]. Two particularly valuable datasets in this respect are the literally millions of gene expression profiles stored in repositories such as GEO [ 25 , 26 ] and a number of increasingly diverse compound screening libraries [ 27 ].…”
Section: Introductionmentioning
confidence: 99%
“…Natural compounds represent an extraordinary inventory of high diversity structural scaffolds that can offer promising candidates in the major healthcare challenge of delaying ageing [ 29 ]. Plant extracts provide a substantial source of potentially active compounds, however so far only few natural compounds have been reported to have anti-senescence effects [ 30 - 34 ]. Based on our previous research results [ 2 ], we developed an assay that uses Pten null cells as a tool to rapidly identify compounds that decrease senescence in primary cells.…”
Section: Introductionmentioning
confidence: 99%
“…Later studies have described the biological activity spectra for 3,4‐DHPEA‐EA and 3,4‐DHPEA‐EDA using PASS (Prediction of Activity Spectra for Substances) software. These reports indicate that the oleuropein derivatives, 3,4‐DHPEA‐EA and 3,4‐DHPEA‐EDA exhibit two naturally occurring isomeric structures with different expected biological activity from hemiacetalic versus dialdehydic forms, and that 3,4‐DHPEA‐EDA favors the open dialdehydic form, which appears to be more conformationally free, and adaptable to interact with a suitable target .…”
Section: Introductionmentioning
confidence: 96%