Computer aided discovery of benzimidazole derivatives on peptide deformylase as antimicrobial agent using hex

Synthesis, characterization and comparative study the antibacterial activities of some imine-amoxicillin derivatives

“…On the other hand, when we show the results of activity against Escherichia coli, Figure 4, we observed some important notes: the first that all compounds (1)(2)(3)(4)(5) in all concentrations have good activity against this bacteria and this inhibition increases with increasing the concentration of compounds. The second is the compound 5 has good activity compared to others.…”

“…it is active against a wide range of Gram-positive, and a limited range of Gram-negative organisms [2]. It is also found that amoxicillin and its derivatives are very importance in many research studies, such as pharmaceutical and biological studies [3][4][5][6].…”

“…Due to the activities associated with amoxicillin and imines, an attempt was made to generate new derivatives containing imine and amoxicillin in the same molecules (1)(2)(3)(4)(5). All the synthesized compounds were further characterized and evaluated for antibacterial activities.…”

Synthesis, characterization and comparative study the antibacterial activities of some imine-amoxicillin derivatives

“…On the other hand, when we show the results of activity against Escherichia coli, Figure 4, we observed some important notes: the first that all compounds (1)(2)(3)(4)(5) in all concentrations have good activity against this bacteria and this inhibition increases with increasing the concentration of compounds. The second is the compound 5 has good activity compared to others.…”

“…it is active against a wide range of Gram-positive, and a limited range of Gram-negative organisms [2]. It is also found that amoxicillin and its derivatives are very importance in many research studies, such as pharmaceutical and biological studies [3][4][5][6].…”

“…Due to the activities associated with amoxicillin and imines, an attempt was made to generate new derivatives containing imine and amoxicillin in the same molecules (1)(2)(3)(4)(5). All the synthesized compounds were further characterized and evaluated for antibacterial activities.…”

1,3,4-Oxadiazole Derivatives: Synthesis, Characterization, Antimicrobial Potential, and Computational Studies

“…Peptide deformylase (PDF) is a vital and extremely conserved enzyme, belongs to a subfamily of metalloprotease [ 15 ], and has emerged out as a target of efforts to develop novel antibacterial agents [ 16 ]. It embraces iron and is responsible for protein maturation by the exclusion of the N-formyl group from the terminal methionine residue through Fe 2+ mediated catalysis which leads to inhibition of protein synthesis in bacteria [ 17 ].…”

Synthesis, characterization and comparative study the antibacterial activities of some imine-amoxicillin derivatives

“…On the other hand, when we show the results of activity against Escherichia coli, Figure 4, we observed some important notes: the first that all compounds (1)(2)(3)(4)(5) in all concentrations have good activity against this bacteria and this inhibition increases with increasing the concentration of compounds. The second is the compound 5 has good activity compared to others.…”

“…it is active against a wide range of Gram-positive, and a limited range of Gram-negative organisms [2]. It is also found that amoxicillin and its derivatives are very importance in many research studies, such as pharmaceutical and biological studies [3][4][5][6].…”

“…Due to the activities associated with amoxicillin and imines, an attempt was made to generate new derivatives containing imine and amoxicillin in the same molecules (1)(2)(3)(4)(5). All the synthesized compounds were further characterized and evaluated for antibacterial activities.…”

1,3,4-Oxadiazole Derivatives: Synthesis, Characterization, Antimicrobial Potential, and Computational Studies

“…Peptide deformylase (PDF) is a vital and extremely conserved enzyme, belongs to a subfamily of metalloprotease [ 15 ], and has emerged out as a target of efforts to develop novel antibacterial agents [ 16 ]. It embraces iron and is responsible for protein maturation by the exclusion of the N-formyl group from the terminal methionine residue through Fe 2+ mediated catalysis which leads to inhibition of protein synthesis in bacteria [ 17 ].…”

Synthesis, characterization and comparative study the antibacterial activities of some imine-amoxicillin derivatives

“…On the other hand, when we show the results of activity against Escherichia coli, Figure 4, we observed some important notes: the first that all compounds (1)(2)(3)(4)(5) in all concentrations have good activity against this bacteria and this inhibition increases with increasing the concentration of compounds. The second is the compound 5 has good activity compared to others.…”

“…it is active against a wide range of Gram-positive, and a limited range of Gram-negative organisms [2]. It is also found that amoxicillin and its derivatives are very importance in many research studies, such as pharmaceutical and biological studies [3][4][5][6].…”

“…Due to the activities associated with amoxicillin and imines, an attempt was made to generate new derivatives containing imine and amoxicillin in the same molecules (1)(2)(3)(4)(5). All the synthesized compounds were further characterized and evaluated for antibacterial activities.…”

1,3,4-Oxadiazole Derivatives: Synthesis, Characterization, Antimicrobial Potential, and Computational Studies

“…Peptide deformylase (PDF) is a vital and extremely conserved enzyme, belongs to a subfamily of metalloprotease [ 15 ], and has emerged out as a target of efforts to develop novel antibacterial agents [ 16 ]. It embraces iron and is responsible for protein maturation by the exclusion of the N-formyl group from the terminal methionine residue through Fe 2+ mediated catalysis which leads to inhibition of protein synthesis in bacteria [ 17 ].…”