Computed tomography-based measurements of normative liver and spleen volumes in children

Alves, Vinicius P V; Dillman, Jonathan R.; Somasundaram, Elanchezhian; Taylor, Zachary P; Brady, Samuel L.; Zhang, Bin; Trout, Andrew T.

doi:10.1007/s00247-022-05551-z

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…This is because there are many scenarios in clinical practice where utilization of corresponding normative measurements obtained in healthy children has been shown to be useful. For example, trunk motion comparisons between children with moderate adolescent idiopathic scoliosis (AIS) and healthy children in [1]; bone age comparisons between patients with bone disorders and healthy children were illustrated in [2]; cognitive function comparisons between children with brain tumors and healthy children in [3]; urinary phosphorus excretion comparisons between children with urolithiasis and healthy children in [4]; vitamin D from plasma comparisons between children with celiac disease and healthy children in [5]; and liver and spleen volume from CTs were collected from healthy children for providing reference ranges and potential thresholds to identify liver and spleen size abnormalities that might reflect disease in children [6].…”

Section: Introductionmentioning

confidence: 99%

Virtual Growing Child (VGC): A general normative comparative system via quantitative dynamic MRI for quantifying pediatric regional respiratory anomalies with application in thoracic insufficiency syndrome (TIS)

Tong,

Udupa,

McDonough

et al. 2024

Preprint

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BackgroundA normative database of regional respiratory structure and function in healthy children does not exist.MethodsVGC provides a database with four categories of regional respiratory measurement parameters including morphological, architectural, dynamic, and developmental. The database has 3,820 3D segmentations (around 100,000 2D slices with segmentations). Age and gender group analysis and comparisons for healthy children were performed using those parameters via two-sided t-testing to compare mean measurements, for left and right sides at end-inspiration (EI) and end-expiration (EE), for different age and gender specific groups. We also apply VGC measurements for comparison with TIS patients via an extrapolation approach to estimate the association between measurement and age via a linear model and to predict measurements for TIS patients. Furthermore, we check the Mahalanobis distance between TIS patients and healthy children of corresponding age.FindingsThe difference between male and female groups (10-12 years) behave differently from that in other age groups which is consistent with physiology/natural growth behavior related to adolescence with higher right lung and right diaphragm tidal volumes for females(p<0.05). The comparison of TIS patients before and after surgery show that the right and left components are not symmetrical, and the left side diaphragm height and tidal volume has been significantly improved after surgery (p <0.05). The left lung volume at EE, and left diaphragm height at EI of TIS patients after surgery are closer to the normal children with a significant smaller Mahalanobis distance (MD) after surgery (p<0.05).InterpretationThe VGC system can serve as a reference standard to quantify regional respiratory abnormalities on dMRI in young patients with various respiratory conditions and facilitate treatment planning and response assessment.FundingThe grant R01HL150147 from the National Institutes of Health (PI Udupa).

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