Computed tomography and magnetic resonance imaging features of ovarian fibrothecoma

Chen, Jingya; Wang, Jianhua; Chen, Xiao; Wang, Yaohui; Wang, Zhongqiu; Li, Dake

doi:10.3892/ol.2017.6228

Cited by 13 publications

(7 citation statements)

References 20 publications

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“…OTCA–FTCA is often prone to secondary cystic transformation when the tumor volume is large. Some scholars have reported that the cystic transformation rate is 76% (19/25) ( 20 ), so the tumor often appears as a cystic–solid or cystic mass, which may be preoperatively misdiagnosed as OGCTs or other ovarian tumor. Other scholars have divided these tumors into solid, cystic, and cystic–solid masses according to the degree of the cystic component.…”

Section: Discussionmentioning

confidence: 99%

The Value of MRI Findings Combined With Texture Analysis in the Differential Diagnosis of Primary Ovarian Granulosa Cell Tumors and Ovarian Thecoma–Fibrothecoma

Shi

Chen

et al. 2021

Front. Oncol.

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ObjectiveThis study aims to explore the value of magnetic resonance imaging (MRI) and texture analysis (TA) in the differential diagnosis of ovarian granulosa cell tumors (OGCTs) and thecoma-fibrothecoma (OTCA–FTCA).MethodsThe preoperative MRI data of 32 patients with OTCA–FTCA and 14 patients with OGCTs, confirmed by pathological examination between June 2013 and August 2020, were retrospectively analyzed. The texture data of three-dimensional MRI scans based on T2-weighted imaging and clinical and conventional MRI features were analyzed and compared between tumor types. The Mann–Whitney U-test, χ2 test/Fisher exact test, and multivariate logistic regression analysis were used to identify differences between the OTCA–FTCA and OGCTs groups. A regression model was established by using binary logistic regression analysis, and receiver operating characteristic curve analysis was carried out to evaluate diagnostic efficiency.ResultsA multivariate analysis of the imaging-based features combined with TA revealed that intratumoral hemorrhage (OR = 0.037), log-sigma-20mm-3D_glszm_SmallAreaEmphasis (OR = 4.40), and log-sigma-2-0mm-3D_glszm_SmallAreaHighGrayLevelEmphasis (OR = 1.034) were independent features for discriminating between OGCTs and OTCA–FTCA (P < 0.05). An imaging-based diagnosis model, TA-based model, and combination model were established. The areas under the curve of the three models in predicting OGCTs and OTCA–FTCA were 0.935, 0.944, and 0.969, respectively; the sensitivities were 93.75, 93.75, and 96.87%, respectively; and the specificities were 85.71, 92.86, and 92.86%, respectively. The DeLong test indicated that the combination model had the highest predictive efficiency (P < 0.05), with no significant difference among the three models in differentiating between OGCTs and OTCA–FTCA (P > 0.05).ConclusionsCompared with OTCA–FTCA, intratumoral hemorrhage may be characteristic MR imaging features with OGCTs. Texture features can reflect the microheterogeneity of OGCTs and OTCA–FTCA. MRI signs and texture features can help differentiate between OGCTs and OTCA–FTCA and provide a more comprehensive and accurate basis for clinical treatment.

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Section: Discussionmentioning

confidence: 99%

The Value of MRI Findings Combined With Texture Analysis in the Differential Diagnosis of Primary Ovarian Granulosa Cell Tumors and Ovarian Thecoma–Fibrothecoma

Shi

Chen

et al. 2021

Front. Oncol.

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“…Ovarian fibroma scan be imaged in various ways on a CT scan. Typical imaging features are well-demarcated, oval-shaped, unilateral solid tumors, the parenchyma of which shows isodensity, hypointense or isointense signal, and mild to moderate enhancement following contrast-medium injection [ 3 , 15 ]. The presence of ascites and pleural effusion advocates the diagnosis of Meigs syndrome, the differential diagnosis of which from cardiomyopathy can be very challenging [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Surgical Treatment of a Rare Case of Ovarian Fibroma Associated With Elevated CA125 Levels in a Patient of Reproductive Age: A Case Report

Thanasa¹,

Thanasa²,

Kamaretsos³

et al. 2023

Cureus

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Small ovarian fibromas (< 10cm) associated with elevated serum CA125 levels are rarely encountered, particularly in women of reproductive age. We report a rare case diagnosed in a 35-year-old patient after adnexectomy for a solid ovarian mass of approximately 5cm in maximum diameter, accompanied by elevated serum CA125 levels. In preoperative evaluation, no signs of inflammation from the genital tract were found, and no medical history of endometriosis, uterine leiomyomas, or non-gynecological cancer was reported. Intraoperative frozen section biopsy of surgical specimen obtained from the ovarian tumor had negative evaluation for malignancy. Histological examination of the surgical specimen confirmed the diagnosis of ovarian fibroma. The postoperative course was uneventful. Two months after surgery, the blood serum CA125 levels were within normal ranges. The patient is assessed at regular intervals in the gynecology outpatient clinic. In this paper, based on the data of the modern literature, a brief review of this rare nosological entity is made.

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“…Both types of tumors—sclerosing stromal tumor and thecoma-fibroma, belong to sex cord stromal tumors and consist of fibrous stroma, but are not synonymous [21] . Radiologically, fibroma is described to typically show low signal intensity on T1-weighted MR images, and marked hypointensity on T2-weighted images [3] ; the contrast medium enhancement of fibromas is heterogeneous and mild-to moderate [ 22 , 23 ]. The sclerosing stromal tumor also shows hypo- or isointensity, compared to normal muscles in T1-weighted images, and intermediate to low signal intensity in T2-weighted images; however, on postcontrast images, a typical early intensive peripheral enhancement with centripetal progression and hypovascularized central area is present [ 3 , 7 ].…”

Section: Discussionmentioning

confidence: 99%

Bilateral ovarian fibromas in a 15-year-old primary amenorrhea patient: a case report

Reitere

Mašinska

Lidaka

et al. 2022

Radiology Case Reports

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A 15-year-old female with primary amenorrhea, obesity, and insulin resistance, was admitted for further examination due to large pelvic masses found during a transabdominal ultrasound, which was performed while assessing the amenorrhea. The magnetic resonance imaging showed bilateral, multifocal fibrosing tumors, originating from both ovaries. A laparotomy was performed, during which the right ovary masses were enucleated and the left adnexectomy was performed. A histological examination of the tissue material revealed bilateral ovarian fibromas with calcification and ossification. The genetic examination confirmed the diagnosis of Gorlin syndrome. The patient recovered well, and on the first follow-up 1 month after surgery, already experienced her first spontaneous menstrual bleeding.

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Computed tomography and magnetic resonance imaging features of ovarian fibrothecoma

Cited by 13 publications

References 20 publications

The Value of MRI Findings Combined With Texture Analysis in the Differential Diagnosis of Primary Ovarian Granulosa Cell Tumors and Ovarian Thecoma–Fibrothecoma

The Value of MRI Findings Combined With Texture Analysis in the Differential Diagnosis of Primary Ovarian Granulosa Cell Tumors and Ovarian Thecoma–Fibrothecoma

Surgical Treatment of a Rare Case of Ovarian Fibroma Associated With Elevated CA125 Levels in a Patient of Reproductive Age: A Case Report

Bilateral ovarian fibromas in a 15-year-old primary amenorrhea patient: a case report

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