Computed Tomography and Bronchoscopy in Endobronchial Tuberculosis

Yanardağ, Halıl; Tetikkurt, Cüneyt; Tetikkurt, Seza; Demirci, Sabriye; Karayel, Tuncer

doi:10.1155/2003/496296

Cited by 22 publications

(22 citation statements)

References 16 publications

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“…Foreign body aspiration is another situation that should be considered in the differential diagnosis of ET (3)(4)(5)(6)11). A patient with asthmatic symptoms, hilar lymph node enlargement and parenchymal infiltration on Thorax CT was biopsied from endobronchial nodular appearance similar to our finding which revealed ET (2).…”

Section: Discussionsupporting

confidence: 78%

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Endobronchial tuberculosis mimicking lymphoma

Uyar¹,

Mete²,

Filiz³

et al. 2011

Gaziantep Med J

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Endobronchial tuberculosis may present with different clinical pictures. We presented a 55 year old patient with complaint of cough. She had palpable supraclavicular and cervical lymph nodes. Thorax CT revealed multiple conglomerated mediastinal lymph nodes. Multiple swollen mucosal nodularities were observed on bilateral endobronchial area during fiberoptic bronchoscopy. Although acidfast bacilli were negative in bronchial lavage fluid, biopsies obtained from the endobronchial nodules revealed caseous granulomatous inflammation compatible with tuberculosis. Improvement was achieved one month following antituberculosis therapy. This case report shows the importance of fiberoptic bronchoscopy in the differential diagnosis of subjects present with multiple mediastinal lymphadenopathies especially in populations where incidence of tuberculosis is high. Keywords: Bronchoscopy; lymphoma; tuberculosis Özet Endobronşial tuberküloz farklı klinik tablolarda karşımıza çıkabilir. Biz bu yazıda öksürük şikayeti olan 55 yaşındaki bir kadın hastayı sunduk. Hastanın palpe edilebilen supraklaviküler ve servikal lenf nodları mevcuttu. Toraks BT'de multipl konglomere mediastinal lenf nodları mevcuttu. Fiberoptik bronkoskopik incelemede ise yaygın mukozadan kabarık mukozal nodülariteler her iki akciğer alanlarında tespit edildi. Bronş lavajı ARB'si negatif olmasına rağmen endobronşial alandan alınan biyopsiler tüberküloza uyan şekilde kazeöz granulomatöz inflamasyonla uyumluydu. Tüberküloz tedavisi başlandıktan bir ay sonra düzelme tespit edildi. Bu olgu sunumu özellikle tüberküloz insidansının yüksek olduğu populasyonlarda multipl mediastinal lenfadenopatilerin ayırıcı tanısında fiberoptik bronkoskopinin önemini göstermektedir.

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Section: Discussionsupporting

confidence: 78%

“…Several reports declared that ET manifests as different presentations. Parenchymal infiltration, especially patchy alveolar type was the most prevalent radiologic finding whereas it can mimic malignancy with partial segmental collapse appearance or right middle lobe syndrome (1,(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Endobronchial tuberculosis mimicking lymphoma

Uyar¹,

Mete²,

Filiz³

et al. 2011

Gaziantep Med J

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“…The rapid evolution of CT technology has allowed for lower radiation exposure and shorter acquisition times 32 33. Eventually the use of virtual CT bronchoscopy, which already has excellent correlation with bronchoscopy, could improve CT specificity for indicating flexible bronchoscopy 34–36…”

Section: Discussionmentioning

confidence: 99%

Could CT scan avoid unnecessary flexible bronchoscopy in children with active pulmonary tuberculosis? A retrospective study

Arlaud

Gorincour²,

Bouvenot³

et al. 2010

Archives of Disease in Childhood

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“…These properties make FDG a good radiotracer for monitoring granulomatous inflammatory lesions. It is therefore not surprising that CT (31) and [ 18 F]FDG-PET have been shown to be useful in imaging TB lesions in humans (11,13,22 [7]. )…”

mentioning

confidence: 99%

Noninvasive Pulmonary [ ¹⁸ F]-2-Fluoro-Deoxy- d -Glucose Positron Emission Tomography Correlates with Bactericidal Activity of Tuberculosis Drug Treatment

Davis¹,

Nuermberger²,

Um³

et al. 2009

Antimicrob Agents Chemother

127

141

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Tools for monitoring response to tuberculosis (TB) treatment are time-consuming and resource intensive. Noninvasive biomarkers have the potential to accelerate TB drug development, but to date, little progress has been made in utilizing imaging technologies. Therefore, in this study, we used noninvasive imaging to monitor response to TB treatment. BALB/c and C3HeB/FeJ mice were aerosol infected with Mycobacterium tuberculosis and administered bactericidal (standard and highly active) or bacteriostatic TB drug regimens. Serial pulmonary [18 F]-2-fluoro-deoxy-D-glucose (FDG) positron emission tomography (PET) was compared with standard microbiologic methods to monitor the response to treatment. [18 F]FDG-PET correctly identified the bactericidal activity of the drug regimens. Imaging required fewer animals; was available in real time, as opposed to having CFU counts 4 weeks later; and could also detect TB relapse in a time frame similar to that of the standard method. Lesion-specific [18 F]FDG-PET activity also broadly correlated with TB treatment in C3HeB/FeJ mice that develop caseating lesions. These studies demonstrate the application of noninvasive imaging to monitor TB treatment response. By reducing animal numbers, these biomarkers will allow costeffective studies of more expensive animal models of TB. Validated markers may also be useful as "point-ofcare" methods to monitor TB treatment in humans.New and shorter drug regimens for tuberculosis (TB) are needed to support global control efforts. However, tools for monitoring TB drug treatment in preclinical studies and clinical trials are time-consuming and resource intensive. For instance, typical phase 3/4 trials entail treating hundreds of patients for at least 6 months and monitoring them for at least 1 year for relapse. Phase 2 studies that monitor patients for 8 weeks for sputum culture conversion are limited because sputum bacterial burdens are not available in real time and do not always correlate closely with overall pulmonary disease. This situation is unlike clinical trials evaluating treatments against human immunodeficiency virus infection, where quantitative viral loads and CD4 counts provide well-validated biomarkers of disease burden and progression of disease, respectively. With the alarming rise of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis infections, which account for up to 20% and 2%, respectively, of the global TB disease burden (6), there is significant interest in the use of validated biomarkers to monitor TB treatment in patients. Since clinical indicators can often be misleading, these biomarkers may allow more rapid identification of patients who relapse or respond poorly to TB treatment. The TB Trials Consortium (TBTC) has expressed an urgent need for development of validated biomarkers for monitoring and detecting relapse during and after TB treatment in patients (29). Several biomarker technologies for monitoring TB treatment are under development, though none utilize imaging technologies (24). A...

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Computed Tomography and Bronchoscopy in Endobronchial Tuberculosis

Abstract: The results suggest that follow-up computed tomography is useful for the evaluation of therapeutic response and complications associated with endobronchial tuberculosis, and may replace bronchoscopy.

Cited by 22 publications

References 16 publications

Endobronchial tuberculosis mimicking lymphoma

Endobronchial tuberculosis mimicking lymphoma

Could CT scan avoid unnecessary flexible bronchoscopy in children with active pulmonary tuberculosis? A retrospective study

Noninvasive Pulmonary [ ¹⁸ F]-2-Fluoro-Deoxy- d -Glucose Positron Emission Tomography Correlates with Bactericidal Activity of Tuberculosis Drug Treatment

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Computed Tomography and Bronchoscopy in Endobronchial Tuberculosis

Abstract: The results suggest that follow-up computed tomography is useful for the evaluation of therapeutic response and complications associated with endobronchial tuberculosis, and may replace bronchoscopy.

Cited by 22 publications

References 16 publications

Endobronchial tuberculosis mimicking lymphoma

Endobronchial tuberculosis mimicking lymphoma

Could CT scan avoid unnecessary flexible bronchoscopy in children with active pulmonary tuberculosis? A retrospective study

Noninvasive Pulmonary [ 18 F]-2-Fluoro-Deoxy- d -Glucose Positron Emission Tomography Correlates with Bactericidal Activity of Tuberculosis Drug Treatment

Contact Info

Product

Resources

About

Noninvasive Pulmonary [ ¹⁸ F]-2-Fluoro-Deoxy- d -Glucose Positron Emission Tomography Correlates with Bactericidal Activity of Tuberculosis Drug Treatment