Computed tomographic emphysema distribution: relationship to clinical features in a cohort of smokers

Mair, Grant; Miller, Joy J.; McAllister, David; Maclay, John D.; Connell, Martin; Murchison, John T; MacNee, William

doi:10.1183/09031936.00111808

Cited by 51 publications

(47 citation statements)

References 24 publications

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“…Analysis of emphysema distribution in COPD patients (FEV 1 % predicted 52 6 19) revealed a predominance of chances in the upper and core regions of the lung (49). Increased core distribution was associated with lower FEV 1 , FEV 1 /FVC ratio, and body mass index (BMI).…”

Section: Quantitative Analysismentioning

confidence: 99%

Imaging phenotypes of chronic obstructive pulmonary disease

Ley‐Zaporozhan¹,

Beek²

2010

Magnetic Resonance Imaging

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Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. COPD is defined by irreversible airflow obstruction. It is a heterogeneous disease affecting the airways and/or the parenchyma with different severity during the course of the disease. These different aspects of COPD can be addressed by imaging using a combination of morphological and functional techniques. Computed tomography (CT) is the technique of choice for morphological imaging of the lung parenchyma and airways. This morphological information is to be accomplished by functional information about ventilation and perfusion, mainly provided by magnetic resonance imaging (MRI). The comprehensive diagnostic possibilities of CT complemented by MRI will allow for a more sensitive detection, phenotype-driven characterization, and dedicated therapy monitoring of the disease.

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Section: Quantitative Analysismentioning

confidence: 99%

Imaging phenotypes of chronic obstructive pulmonary disease

Ley‐Zaporozhan¹,

Beek²

2010

Magnetic Resonance Imaging

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“…All scans were evaluated centrally at the University of Edinburgh. Emphysema was quantified as the percentage of lung CT voxels below a threshold of −950 Hounsfield Units-% low attenuation areas (LAA)-950, using the software Pulmonary Workstation 2.0 (VIDA Diagnostics, Iowa City, IA, USA) as described previously [13][14][15]. MMP-9 ELISA and MMP-9 activity kits (fluorescence resonance energy transfer (FRET) method) were supplied by R&D Systems Europe Ltd. (Cat.…”

Section: Measurementsmentioning

confidence: 99%

Sputum matrix metalloproteinase-9 is associated with the degree of emphysema on computed tomography in COPD

et al. 2013

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Background: Matrix-metalloproteinase (MMP)-9 has been implicated in the pathogenesis of COPD, although its link to disease severity is unclear. The purpose of the study was to examine the relationship between disease severity assessed by lung function and computed tomography (CT) and sputum MMP-9 expression, concentration and activity in patients with COPD. Findings: In 53 COPD subjects, smokers and ex-smokers; 46 healthy controls, smokers and never smokers, we measured sputum MMP-9 concentrations (ELISA) and enzyme activity (FRET), sputum MMP-9 mRNA expression, spirometry, diffusing capacity for carbon monoxide (DLco) and CT assessment of emphysema (% low attenuation areas below-950 Hounsfield units). Sputum MMP-9 concentrations and mRNA expression in COPD subjects were significantly greater than in healthy never-smokers (p = 0.007 and p = 0.001 respectively) and similar to those in healthy smokers. Conclusions: Sputum MMP-9 concentrations in COPD are directly associated with the extent of emphysema measured by CT and MMP-9 expression levels are inversely associated with DLco. These findings support a role for MMP-9 in the pathogenesis of COPD.

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“…Mair et al [20] analyzed variables that might predict the severity of emphysema and found that BMI was the best predictor. In our patient population, we found a strong inverse correlation between BMI and extend of emphysema that is in correlation the knowledge that BMI is tightly associated with emphysema, at least in patients with normal BMI and diffuse emphysema.…”

Section: Discussionmentioning

confidence: 99%