Computational investigation for deformation of lipid membrane by BAR proteins due to electrostatic interaction

Mahata, Paritosh; Singhal, Lakshya; Prasad, Rajendra; Kumar, K. Ashok; Bakshi, Shubham; Raj, Pranav; Choudhary, Harsh; Biswas, Ankit

doi:10.1016/j.matpr.2022.03.012

Cited by 3 publications

(1 citation statement)

References 40 publications

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“… 2014 ; Mahata et al. 2022 ; Carotenuto et al. 2021 )), thereby neglecting the self-capability of lipid bilayers to re-organise themselves in ordered and disordered patches even in absence of proteins (Deseri and Zurlo 2013 ; Deseri et al.…”

Section: Introductionmentioning

confidence: 99%

Modelling lipid rafts formation through chemo-mechanical interplay triggered by receptor–ligand binding

Bernard,

Carotenuto,

Pugno

et al. 2023

Biomech Model Mechanobiol

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Cell membranes, mediator of many biological mechanisms from adhesion and metabolism up to mutation and infection, are highly dynamic and heterogeneous environments exhibiting a strong coupling between biochemical events and structural re-organisation. This involves conformational changes induced, at lower scales, by lipid order transitions and by the micro-mechanical interplay of lipids with transmembrane proteins and molecular diffusion. Particular attention is focused on lipid rafts, ordered lipid microdomains rich of signalling proteins, that co-localise to enhance substance trafficking and activate different intracellular biochemical pathways. In this framework, the theoretical modelling of the dynamic clustering of lipid rafts implies a full multiphysics coupling between the kinetics of phase changes and the mechanical work performed by transmembrane proteins on lipids, involving the bilayer elasticity. This mechanism produces complex interspecific dynamics in which membrane stresses and chemical potentials do compete by determining different morphological arrangements, alteration in diffusive walkways and coalescence phenomena, with a consequent influence on both signalling potential and intracellular processes. Therefore, after identifying the leading chemo-mechanical interactions, the present work investigates from a modelling perspective the spatio-temporal evolution of raft domains to theoretically explain co-localisation and synergy between proteins’ activation and raft formation, by coupling diffusive and mechanical phenomena to observe different morphological patterns and clustering of ordered lipids. This could help to gain new insights into the remodelling of cell membranes and could potentially suggest mechanically based strategies to control their selectivity, by orienting intracellular functions and mechanotransduction.

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Section: Introductionmentioning

confidence: 99%

Modelling lipid rafts formation through chemo-mechanical interplay triggered by receptor–ligand binding

Bernard,

Carotenuto,

Pugno

et al. 2023

Biomech Model Mechanobiol

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The interplay between membrane viscosity and ligand-binding receptor kinetics in lipid bilayers

Bernard,

Carotenuto,

Pugno

et al. 2024

Meccanica

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Plasma membranes appear as deformable systems wherein molecules are free to move and diffuse giving rise to condensed microdomains (composed of ordered lipids, transmembrane proteins and cholesterol) surrounded by disordered lipid molecules. Such denser and thicker regions, namely lipid rafts, are important communication hubs for cells. Indeed, recent experiments revealed how the most of active signaling proteins co-localize on such domains, thereby intensifying the biochemical trafficking of substances. From a material standpoint, it is reasonable to assume the bilayer as a visco-elastic body accounting for both in-plane fluidity and elasticity. Consequently, lipid rafts contribute to membrane heterogeneity by typically exhibiting higher stiffness and viscosity and by locally altering the bilayer dynamics and proteins activity. A chemo-mechanical model of lipid bilayer coupled with interspecific dynamics among the resident species (typically transmembrane receptors and trasporters) has been recently formulated to explain and predict how proteins regulate the dynamic heterogeneity of membrane. However, the explicit inclusion of the membrane viscosity in the model was not considered. To this aim, the present work enriches the constitutive description of the bilayer by modeling its visco-elastic behavior. This is done through a strain-level dependent viscosity able to theoretically trace back the alteration of membrane fluidity experimentally observed in lipid phase transitions. This provides new insights into how the quasi-solid and fluid components of lipid membrane response interact with the evolution of resident proteins by affecting the activity of raft domains, with effects on cell mechano-signaling.

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Deformation of thin Mooney–Rivlin elastic sheet due to electrostatic interaction with a rigid curved domain implied to biosystems

Mahata,

Kumar,

Shrivastava

et al. 2024

J Braz. Soc. Mech. Sci. Eng.

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Computational investigation for deformation of lipid membrane by BAR proteins due to electrostatic interaction

Cited by 3 publications

References 40 publications

Modelling lipid rafts formation through chemo-mechanical interplay triggered by receptor–ligand binding

Modelling lipid rafts formation through chemo-mechanical interplay triggered by receptor–ligand binding

The interplay between membrane viscosity and ligand-binding receptor kinetics in lipid bilayers

Deformation of thin Mooney–Rivlin elastic sheet due to electrostatic interaction with a rigid curved domain implied to biosystems

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