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Cited by 352 publications
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References 40 publications
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“…These results are consistent with our findings that dynamic compression decreased the stimulation of NO production by IL-1. It is important to note that compression of cells in an explant, as we have used, will likely expose the cells to a significantly different mechanical environment at the cellular level (24,26) compared with tensile stretch in monolayer.…”
Section: Discussionmentioning
confidence: 99%
“…These results are consistent with our findings that dynamic compression decreased the stimulation of NO production by IL-1. It is important to note that compression of cells in an explant, as we have used, will likely expose the cells to a significantly different mechanical environment at the cellular level (24,26) compared with tensile stretch in monolayer.…”
Section: Discussionmentioning
confidence: 99%
“…The deformation of chondrocytes has been previously measured, generally under static deformation, in native cartilage (Guilak 1995;Guilak et al, 1995;Guilak et al, 1999;Clark et al, 2003) and in other scaffold materials, e.g. agarose ( Lee and Bader, 1995;Knight et al, 2002).…”
Section: No Chahine Et Almentioning
confidence: 99%
“…These studies investigated the effect of static loading on cell morphology, deformation index (aspect ratio of cell), cross sectional area and cell volume. In native cartilage, it has been shown that chondrocytes and their nuclei undergo significant changes in shape and volume under static loading, and that the chondrocytes respond differently based on their location through the depth of the tissue (Guilak, 1995;Guilak et al, 1995). For chondrocytes cultured in agarose hydrogels, it was found that matrix elaborated by the cells markedly influenced levels of cell deformation; where an increase in matrix elaboration led to a decrease in cell deformation under static loading (Lee and Bader, 1995).…”
Section: No Chahine Et Almentioning
confidence: 99%
“…The degree of change in volume was investigated for chondrocytes embedded in a gel (Guilak, 1995), which reported that 15% compression caused 9.8% volume changes in chondrocyte nucleus. However, the nucleus volume change for adherent vascular cells caused by physiological stress is poorly understood.…”
Section: Appendix Amentioning
confidence: 99%