Compressão de sinais ECG utilizando DWT com quantização não-linear e por sub-bandas

Campitelli, Marcelo Adrián

doi:10.26512/2015.12.d.19564

Cited by 5 publications

(3 citation statements)

References 42 publications

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“…Gene ontology enrichment analysis was performed on the top 250 genes from each component (from each side) using the enrichGO function from the clusterProfiler R package in which p-values are calculated based on the hypergeometric distribution and corrected for testing of multiple biological process GO terms using the Benjamini-Hochberg procedure (Yu et al, 2012). Plots were created using the ggplot2 package and extensions ggrepel, ggforce, ggseqlogo, ggnewscale, ggrastr, RColorBrewer, viridis, and cowplot (Campitelli, 2019; Garnier, 2018; Neuwirth, 2014; Pedersen, 2016; Petukhov, 2018; Wagih, 2017; Wickham, 2016; Wilke, 2018). In addition the following R packages were used: data.table, Matrix (for sparse large matrix computations), biomaRt (for gene identifiers), shiny and shinycssloaders (for creating the interactive web application), ComplexHeatmap, bigmemory (for creating a low-memory shiny app), and MASS (for kernel density estimation) (Bates and Maechler, 2018; Chang et al, 2018; Dowle and Srinivasan, 2019; Durinck et al, 2005; Gu et al, 2016; Kane et al, 2013; Sali, 2017; Venables and Ripley, 2002).…”

Section: Methodsmentioning

confidence: 99%

Unified single-cell analysis of testis gene regulation and pathology in five mouse strains

Jung

Wells

Rusch

et al. 2019

eLife

124

143

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To fully exploit the potential of single-cell functional genomics in the study of development and disease, robust methods are needed to simplify the analysis of data across samples, time-points and individuals. Here we introduce a model-based factor analysis method, SDA, to analyze a novel 57,600 cell dataset from the testes of wild-type mice and mice with gonadal defects due to disruption of the genes Mlh3, Hormad1, Cul4a or Cnp. By jointly analyzing mutant and wild-type cells we decomposed our data into 46 components that identify novel meiotic gene-regulatory programs, mutant-specific pathological processes, and technical effects, and provide a framework for imputation. We identify, de novo, DNA sequence motifs associated with individual components that define temporally varying modes of gene expression control. Analysis of SDA components also led us to identify a rare population of macrophages within the seminiferous tubules of Mlh3-/- and Hormad1-/- mice, an area typically associated with immune privilege.

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Section: Methodsmentioning

confidence: 99%

Unified single-cell analysis of testis gene regulation and pathology in five mouse strains

Jung

Wells

Rusch

et al. 2019

eLife

124

143

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“…In instances where the hit rate was 100%, ( n -1)/ n was substituted as the hit rate in the d’ calculation, where n is the number of trials. Plots were generated in R with ggplot2 (Wickham et al, 2019), ggpubr (Kassambara, 2020), ggnewscale (Campitelli, 2020), and corrplot (Wei et al, 2017). Experiment and analysis code, as well as associated raw data, are available on KiltHub (CMU; digital object identifier: 10.1184/R1/12743276).…”

Section: Methodsmentioning

confidence: 99%

With Childhood Hemispherectomy, One Hemisphere Can Support--But is Suboptimal for--Word and Face Recognition

Granovetter

Ettensohn

Behrmann

2020

Preprint

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The left and right cerebral hemispheres are important for word and face recognition, respectively—a specialization that emerges over human development. But children who have undergone a hemispherectomy develop with only one hemisphere. The question is whether this preserved hemisphere, be it left or right, can support both word and face recognition. Here, a large sample of patients with childhood hemispherectomy and age-matched controls performed word- and face-matching tasks. Controls viewed stimuli either in one visual field (restricting initial processing to one hemisphere) or, like the patients, in central vision. Across word and face tasks, patients performed comparably to controls using primarily one hemisphere, but more poorly than controls viewing stimuli centrally with both hemispheres engaged. Additionally, patients showed deficits in low-level visual processing that may explain their word/face recognition deficits relative to controls. Altogether, the findings suggest that either hemisphere alone can support word and face recognition, albeit sub-optimally.

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“…Supplementary Table1 [ 28 ] and openxlsx [ 29 ] were used for table output. Ggplot2 [ 30 ], ggpubr [ 31 ], ggh4x [ 32 ], ggnewscale [ 33 ], and officer [ 34 ] were used for visualization.…”

Section: Methodsmentioning

confidence: 99%

Barriers and Facilitators to the Implementation of an Electronic Patient-Reported Outcome System at Cancer Hospitals in Japan

Uneno,

Fukuyama,

Nishimura

et al. 2024

Cureus

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Background and objective Implementing electronic patient-reported outcomes (ePROs) in oncology practice has shown substantial clinical benefits. However, it can be challenging in routine practice, warranting strategies to adapt to different clinical contexts. In light of this, this study aimed to describe the implementation process of the ePRO system and elucidate the provider-level implementation barriers and facilitators to a novel ePRO system at cancer hospitals in Japan. Methods We implemented an ePRO system linked to electronic medical records at three cancer hospitals. Fifteen patients with solid cancers at the outpatient oncology unit were asked to regularly complete the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE™) questionnaire and European Organization for Research and Treatment Core Quality of Life questionnaire (EORTC QLQ C30) by using the smartphone app between October 2021 and June 2022. Thirteen healthcare professionals were interviewed to identify implementation barriers and facilitators to the ePRO system by using the Consolidated Framework for Implementation Research framework. Results The healthcare professionals identified a lack of clinical resources and a culture and system that emphasizes treatment over care as the main barriers; however, the accumulation of successful cases, the leadership of managers, and the growing needs of patients can serve as facilitators to the implementation. Conclusions Our experience implementing an ePRO system in a few Japanese oncology practices revealed comprehensive barriers and facilitators. Further efforts are warranted to develop more successful implementation strategies.

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Compressão de sinais ECG utilizando DWT com quantização não-linear e por sub-bandas

Cited by 5 publications

References 42 publications

Unified single-cell analysis of testis gene regulation and pathology in five mouse strains

Unified single-cell analysis of testis gene regulation and pathology in five mouse strains

With Childhood Hemispherectomy, One Hemisphere Can Support--But is Suboptimal for--Word and Face Recognition

Barriers and Facilitators to the Implementation of an Electronic Patient-Reported Outcome System at Cancer Hospitals in Japan

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