Comprehensive strategy for chiral separations using sulfated cyclodextrins in capillary electrophoresis

Abstract

This review focuses on the emerging role of sulfated cyclodextrins in the capillary electrophoretic (CE) separation of chiral analytes. Since being introduced as enantioselective agents for CE in 1995, these anionic additives have continued to demonstrate remarkable application universality. The broad spectrum of chiral compounds successfully separated using this approach includes acidic, basic, neutral, and zwitterionic species. This impressive array of analyte structures is derived from a growing diversity of compound classes including pharmaceuticals, plant extracts, biomarkers, herbicides, alkaloids, fungicides, and metal ions. Moreover, literature reports highlight the minimal optimization required to achieve a successful separation. Based on these findings, sulfated cyclodextrins appear to be well suited for the development of a more universal, comprehensive separation strategy for chiral compounds. This review explores this proposition by beginning with the structure and migration properties of sulfated cyclodextrins, using applications to highlight the separating power of this technique and ending with a pragmatic, comprehensive separation strategy.

Review of aqueous chiral electrokinetic chromatography (EKC) with an emphasis on chiral microemulsion EKC

“…The literature is dominated by CD usage, see ref. [70][71][72] for recent reviews. In many cases, CDs are combined with other PSPs to either produce or improve resolution.…”

Inclusion excluded: Chiroptical sensing of the external surface of sulfated cyclodextrins

“…Sulfated cyclodextrins (CDXs) are highly hydrophilic, effective chiral selectors for the separation of enantiomers of chemically diverse cationic and neutral drugs [1]. Attached to the hydroxyl sites of the macrocycle, sulfate moieties can form hydrogen and ionic bonds with guest compounds.…”

Simultaneous enantioseparation of antiparkinsonian medication Rotigotine and related chiral impurities by capillary zone electrophoresis using dual cyclodextrin system

“…Therefore, chiral selectors carrying opposite charge to that of the selectands are very commonly utilized [7]. Several reviews have been published on the application of sulfated ␤-cyclodextrin (S-␤-CD) to the chiral CE [11,12].…”