Comprehensive profiling of L1 retrotransposons in mouse
Xuanming Zhang,
Ivana Celic,
Hannah Mitchell
et al.
Abstract:L1 elements are retrotransposons currently active in mammals. Although L1s are typically silenced in most normal tissues, elevated L1 expression is associated with a variety of conditions, including cancer, aging, infertility, and neurological disease. These associations have raised interest in the mapping of human endogenousde novoL1 insertions, and a variety of methods have been developed for this purpose. Adapting these methods to mouse genomes would allow us to monitor endogenousin vivoL1 activity in contr… Show more
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