2017
DOI: 10.18632/aging.101176
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Abstract: Advanced age portends a poorer prognosis in FSGS. To understand the impact of age on glomerular podocytes and parietal epithelial cells (PECs), experimental FSGS was induced in 3m-old mice (20-year old human age) and 27m-old mice (78-year old human age) by abruptly depleting podocytes with a cytopathic anti-podocyte antibody. Despite similar binding of the disease-inducing antibody, podocyte density was lower in aged FSGS mice compared to young FSGS mice. Activated PEC density was higher in aged versus young F… Show more

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Cited by 24 publications
(45 citation statements)
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References 58 publications
(109 reference statements)
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“…A hallmark of mammalian aging is a switch in cellular identity that resembles the epithelial to mesenchymal transition (EMT) (Brack et al, 2007;Roeder et al, 2015;Schneider et al, 2017).…”
Section: Cellular Identity Changes In Ice Micementioning
confidence: 99%
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“…A hallmark of mammalian aging is a switch in cellular identity that resembles the epithelial to mesenchymal transition (EMT) (Brack et al, 2007;Roeder et al, 2015;Schneider et al, 2017).…”
Section: Cellular Identity Changes In Ice Micementioning
confidence: 99%
“…Podocyte density was quantitated following staining for p57 on formalin fixed, paraffinembedded, 4 µm kidney sections as previously described (Ohse et al, 2010;Schneider et al, 2017;Zhang et al, 2013). Briefly, Histoclear (National Diagnostics, Atlanta, GA) was used to deparaffinize kidney sections, followed by rehydration using graded 100%, 95%, and 70% ethanol baths.…”
Section: Podocyte Density P57 and Pas Representative Imagesmentioning
confidence: 99%
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“…With the global population living longer, increasing attention is focusing on the impact of advanced age on organ function, and how this might impact normal biological processes and pathways. Recent studies have shown functional and structural changes in the healthy aged kidney, and how these changes might impact outcomes in glomerular and tubulointerstitial diseases [ 1 , 2 ]. For example, because of their biological functions in blood pressure and sodium regulation, changes to the cells of renin lineage (CoRL) have characteristically been considered of major functional importance with increasing kidney age.…”
Section: Introductionmentioning
confidence: 99%
“…ith an aging population, attention has increasingly focused on age-associated changes in many different organs. Several predictable glomerular changes occur in the aged human, 1,2 canine, 3 rat, [4][5][6] and mouse [7][8][9][10] kidneys, including fibrosis and hypertrophy, and changes to parietal epithelial cells, [11][12][13][14] and podocytes. 4,5,[15][16][17] What is increasingly clear is that the decline in kidney function with aging cannot be solely explained by nephrosclerosis per se.…”
mentioning
confidence: 99%