Compound blue nevus: a variant of blue nevus with an additional junctional dendritic component. A clinical, histopathologic, and immunohistochemical study of six cases

Kamino, Hideko

doi:10.1001/archderm.126.10.1330

Cited by 20 publications

(10 citation statements)

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“…We have successfully used this technique in a recently published study of compound blue nevi (8). The use of Giemsa stain, which is based in part on azure B, was mentioned brielly in a report which compared five melanoma antibodies (16).…”

Section: Discussionmentioning

confidence: 99%

“…In order to overcome these technical limitations, we used azure B instead of hematoxylin as a counterstain, since azure B stains melanin green-blue and makes a strong contrast with the brown DAB product. We mentioned briefly this technique in a recently published study of compound blue nevi (8). Because we have found that modifying the PAP technique by counterstaining with azure B is simple and useful, we decided to emphasize its application in diagnosing heavily pigmented melanocytic neoplasms.…”

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confidence: 99%

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Immunoperoxidase technique modified by counterstain with azure B as a diagnostic aid in evaluating heavily pigmented melanocytic neoplasms

Kamino

Tam

1991

J Cutan Pathol

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Heavily-pigmented melanocytic neoplasms are difficult to evaluate on routine hematoxylin and eosin stained slides because pigmented melanocytes are difficult to distinguish from the numerous melanophages that are usually seen in the background of these lesions. Immunoperoxidase staining for S100 protein or HMB-45 antibody using diaminobenzidine (DAB) as chromogen, which forms a brown product, does not adequately distinguish melanocytes from melanophages. We modified this technique by replacing hematoxylin as the counterstain with azure B, which stains melanin green-blue. Thus, positive melanocytes appear brown while melanin granules in their cytoplasm are green-blue. However, negative melanophages only stain green-blue. This technique is useful in evaluating heavily pigmented melanocytic lesions such as malignant melanomas, melanosis of regressing malignant melanoma, residual malignant melanoma in areas of granulation tissue with melanophages, blue nevi, pigmented spindle cell variant of Spitz's nevi and combined nevi.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Immunoperoxidase technique modified by counterstain with azure B as a diagnostic aid in evaluating heavily pigmented melanocytic neoplasms

Kamino

Tam

1991

J Cutan Pathol

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“…1 On the other hand, compound blue nevus is defined as blue nevus with dendritic melanocytes in the junctional region, and not arranged as nests. 2 Our case clearly showed nevus cell nests, leading to the diagnosis of combined nevus.…”

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confidence: 52%

Case of combined nevus showing a speckled distribution pattern

Yaginuma

Nobeyama

Miyake-Nakano

et al. 2018

The Journal of Dermatology

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Case of combined nevus showing a speckled distribution patternDear Editor, Combined nevus or melanocytic nevus with phenotypic heterogeneity is either a congenital or acquired melanocytic nevus containing two or more distinct melanocytic nevus components, including common acquired nevus, congenital nevus, dysplastic nevus, blue nevus, Spitz nevus, deep penetrating nevus and plexiform pigmented spindle cell nevus. 1 The clinical manifestations of combined nevi are closely related to the types of predominant cellular populations. 1 Because the morphological features of combined nevi are not yet comprehensively understood, combined nevi are often misdiagnosed as blue nevi or even melanomas. We encountered a case of combined nevus showing a speckled distribution pattern.A 25-year-old Japanese man was referred to us with a 10year history of speckled macular/papular lesion on the abdomen, which resulted from a homogeneous bluish macule at birth. Physical examination revealed an ovoid-shaped, faintly bluish lesion measuring 53 mm 9 20 mm on the abdomen with

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“…However, this classification is unsatisfactory because no clear-cut clinical or histologic distinction can be made in many cases (2). Other rare variants include combined (3), plaque-like (4), compound (5), and malignant (6) blue nevi. The term combined type nevus refers to the presence of more than one type of nevus cell.…”

Section: Discussionmentioning

confidence: 99%