Compositions of Serum Lipids, Lipoproteins, and Lipoprotein Fatty Acids in Type IV Primary Hypertriglyceridemia.

Abstract

SummaryThe overall composition of serum lipoproteins and the fatty acid composition of cholesterol esters and phospholipids in the VLDL, IDL, LDL, and HDL were studied in eleven patients with familial type IV primary hypertriglyceridemia. The patients were divided into two groups: HTG 1 (serum triglycerides below 350 mg/dl: 200-294, n = 5) and HTG2 (serum triglycerides above 350 mg/dl: 368-820, n = 6). The data were compared with those from 9 normolipidemic subjects.The proportion of the constituents of VLDL was normal in the HTG 1 group, but cholesterol esters were increased and triglycerides decreased in this fraction in the HTG2 one. The increase in triglycerides and decrease in cholesterol esters in LDL and HDL modified the CE/TG and TG/total lipoprotein ratios in both groups of patients. The core lipid/surface ratio was increased in HDL in both groups, but not in the other three fractions.The saturated fatty acids of cholesterol esters were low (p<0.01) in the VLDL of the HTG2 group. The w6 fatty acids of cholesterol esters and phospholipids were slightly increased (p<0.05) in the VLDL in the same group. However, there was a decrease in the c6 fatty acids in cholesterol esters (p<0.05) and in the phospholipids (p<0.01) in the IDL of the HTG 1 group. There was no significant difference in the LDL fatty acid composition between the hypertriglyceridemic patients and the controls. The phospholipids of the HDL in the HTG2 group contained less (p.(0.05) saturated fatty acids and more (p<0.05) polyunsaturated fatty acids than did those in the HTG 1 group.These observations suggest that the fatty acid composition of lipoproteins in hypertriglyceridemic subjects is not markedly altered and is

Lipoprotein composition and oxidative modification during therapy with gemfibrozil and lovastatin in patients with combined hyperlipidaemia

“…Regarding oxidation-related analytes are referred to milligrams of LDLprotein as in our study. In accord with the results of Bredie lipoprotein fatty acid composition, comparison of values reported for normolipidaemic subjects [20,21] with those et al [24], gemfibrozil treatment also had no effect on LDL oxidizability in our patients. reported in Table 2 shows no major differences.…”

Treatment with omega-3 fatty acid ethyl-ester alters fatty acid composition of lipoproteins in overweight or obese adults with insulin resistance

“…The concordance of these two parameters provides a first-level of evidence that fatty acid composition mediates some HDL function. Previously described data regarding the influence of ingested fatty acids on the composition of blood lipoproteins are limited in size and scope [33] in comparison to these data. One study noted that corn oil consumption in a single subject increased the ratio of linoleic acid to oleic acid in lipoprotein fractions of different density, but did not measure other fatty acids [34].…”