Compositions and antimicrobial properties of binary ZnO–CuO nanocomposites encapsulated calcium and carbon from Calotropis gigantea targeted for skin pathogens

Govindasamy, G Ambarasan; Mydin, Rabiatul Basria S. M. N.; Sreekantan, Srimala; Harun, Nor Hazliana

doi:10.1038/s41598-020-79547-w

Cited by 57 publications

(15 citation statements)

References 62 publications

(62 reference statements)

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“…The rod-shaped binary NPs had a diameter of 7.5 nm and a length of 8.1 nm. In addition, they were able to inhibit ARB K. pneumoniae and P. aeruginosa and MRSA with MIC values of 0.625, 0.156, and 0.156 mg/mL, respectively [ 169 ]. Azizi et al (2017) fabricated hydrogel beads based on κ-Carrageenan loading biosynthesized Ag-NPs using Citrullus colocynthis seed extract [ 170 ].…”

Section: Other Plant-based Nanomaterialsmentioning

confidence: 99%

Phytochemical-Based Nanomaterials against Antibiotic-Resistant Bacteria: An Updated Review

et al. 2023

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Antibiotic-resistant bacteria (ARB) is a growing global health threat, leading to the search for alternative strategies to combat bacterial infections. Phytochemicals, which are naturally occurring compounds found in plants, have shown potential as antimicrobial agents; however, therapy with these agents has certain limitations. The use of nanotechnology combined with antibacterial phytochemicals could help achieve greater antibacterial capacity against ARB by providing improved mechanical, physicochemical, biopharmaceutical, bioavailability, morphological or release properties. This review aims to provide an updated overview of the current state of research on the use of phytochemical-based nanomaterials for the treatment against ARB, with a special focus on polymeric nanofibers and nanoparticles. The review discusses the various types of phytochemicals that have been incorporated into different nanomaterials, the methods used to synthesize these materials, and the results of studies evaluating their antimicrobial activity. The challenges and limitations of using phytochemical-based nanomaterials, as well as future directions for research in this field, are also considered here. Overall, this review highlights the potential of phytochemical-based nanomaterials as a promising strategy for the treatment against ARB, but also stresses the need for further studies to fully understand their mechanisms of action and optimize their use in clinical settings.

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Section: Other Plant-based Nanomaterialsmentioning

confidence: 99%

Phytochemical-Based Nanomaterials against Antibiotic-Resistant Bacteria: An Updated Review

et al. 2023

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“…Due to the growing resistance of bacteria to antibiotics, biomaterial experts have focused their researches on the use of antibacterial nanoparticles such as silver (Ag), copper (Cu), and zinc oxide (ZnO) in biomedical applications. [ 165 ] A summary of previous studies on the addition of antibacterial nanoparticles to a polymer matrix is given in Table 2 .…”

Section: Antibacterial Nanoparticlesmentioning

confidence: 99%

An Overview on the Recent Advances in the Treatment of Infected Wounds: Antibacterial Wound Dressings

Mirhaj

Labbaf

Tavakoli

et al. 2022

Macromolecular Bioscience

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A wound can be surgical cuts from an operation or due to accident and trauma. The infected wound, as a result of bacteria growth within the damaged skin, interrupts the natural wound healing process and significantly impacts the quality of life. Wound dressing is an important segment of the skincare industry with its economic burden estimated at $ 20.4 billion (in 2021) in the global market. The results of recent clinical trials suggest that the use of modern dressings can be the easiest, most accessible, and most cost‐effective way to treat chronic wounds and, hence, holds significant promise. With the sheer number of dressings in the market, the selection of correct dressing is confusing for clinicians and healthcare workers. The aim of this research is to review widely used types of antibacterial wound dressings, as well as emerging products, for their efficiency and mode of action. In this review, introducing antibiotics and antibacterial nanoparticles as two important and clinically widely used categories of antibacterial agents is focused. The perspectives and challenges for paving the way for future research in this field are also discussed.

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“…These large shrubs have also been extensively cultivated in tropical areas around the world and typically grow to eight to 15 feet tall (Dutta et al, 2021). An eco-friendly nanotechnology method and Calotropis gigantea extract could offer promising antibacterial action against skin infections (Govindasamy et al, 2021). Asthma, swollen rheumatism, diarrhoea, dysentery, syphilis, ulcer, leprosy and other common diseases are all traditionally treated with it either alone or in combination with other medicinal plants (Timilsina et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Bioactive Potential of Aqueous Extract of Calotropis gigantea against Echis carinatus Venom

Kumar¹,

Jayaseelan²,

Dinesh³

et al. 2022

IJARe

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Background: Many plants are used to cure snakebites in Indian traditional medicine and some of them have been examined for their ability to neutralize snake venom. The main aim of the present study is the screening of phytochemicals, in vitro assessment of venom toxicity and neutralization assays and its antimicrobial assay. Methods: The phytochemical screening and thin-layer chromatography was used to determine and separate the chemical constituents present in the Calotropis gigantea. The direct hemolysis using sheep RBCs was studied for Echis carinatus venoms. The proteolytic, neutralizing and antimicrobial activity of the extract was also studied. Result: The phytochemical investigation of root extract of Calotropis gigantean and the TLC was performed. The Protein concentration of the lyophilized snake venoms was found to be 0.692 mg/ml. Echis carinatus venoms showed 89% hemolysis. Echis carinatus venom produced a reduced zone of hydrolysis with the extract. The absence of clot formation showed the neutralizing ability of plant extracts in gelatin liquefaction assay. Thus the scientific confirmation of neutralization potential of Calotropis gigantea plant extract against Saw scaled viper (Echis carinatus) venom was performed.

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Compositions and antimicrobial properties of binary ZnO–CuO nanocomposites encapsulated calcium and carbon from Calotropis gigantea targeted for skin pathogens

Cited by 57 publications

References 62 publications

Phytochemical-Based Nanomaterials against Antibiotic-Resistant Bacteria: An Updated Review

Phytochemical-Based Nanomaterials against Antibiotic-Resistant Bacteria: An Updated Review

An Overview on the Recent Advances in the Treatment of Infected Wounds: Antibacterial Wound Dressings

Bioactive Potential of Aqueous Extract of Calotropis gigantea against Echis carinatus Venom

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