Composition of the essential oil from the leaves of tree domestic varieties and one wild variety of the guava plant (Psidium guajava L., Myrtaceae)

Lima, Rafaela Karin; Cardoso, María das Graças; Andrade, Milene Aparecida; Nascimento, Evandro A.; Morais, Sérgio Antônio Lemos de; Nelson, David Lee

doi:10.1590/s0102-695x2010000100009

Cited by 24 publications

(10 citation statements)

References 22 publications

(21 reference statements)

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“…*Address correspondence to this author at the Department of Experimental Molecular Imaging (ExMI), RWTH Aachen University, Pauwelsstrasse 20, 52074, Aachen, Germany; Tel: 0049-241-8080254; E-mail: lyokotarizzo@ukaachen.de Psidium guajava L. (Myrtaceae) is a fruit-bearing tree popularly known as 'guava', broadly employed by the food and cosmetic industry [3]. Several phytochemicals have been described from guava leaf extracts, such as essential oils, flavonoids, phenols, terpenoids, tannins, vitamins and fibers [4].…”

Section: Introductionmentioning

confidence: 99%

In Vitro, In Vivo and In Silico Analysis of the Anticancer and Estrogen-like Activity of Guava Leaf Extracts

Rizzo¹,

Longato²,

Ruiz³

et al. 2014

CMC

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Anticancer drug research based on natural compounds enabled the discovery of many drugs currently used in cancer therapy. Here, we report the in vitro, in vivo and in silico anticancer and estrogen-like activity of Psidium guajava L. (guava) extracts and enriched mixture containing the meroterpenes guajadial, psidial A and psiguadial A and B. All samples were evaluated in vitro for anticancer activity against nine human cancer lines: K562 (leukemia), MCF7 (breast), NCI/ADR-RES (resistant ovarian cancer), NCI-H460 (lung), UACC-62 (melanoma), PC-3 (prostate), HT-29 (colon), OVCAR-3 (ovarian) and 786-0 (kidney). Psidium guajava's active compounds displayed similar physicochemical properties to estradiol and tamoxifen, as in silico molecular docking studies demonstrated that they fit into the estrogen receptors (ERs). The meroterpene-enriched fraction was also evaluated in vivo in a Solid Ehrlich murine breast adenocarcinoma model, and showed to be highly effective in inhibiting tumor growth, also demonstrating uterus increase in comparison to negative controls. The ability of guajadial, psidial A and psiguadials A and B to reduce tumor growth and stimulate uterus proliferation, as well as their in silico docking similarity to tamoxifen, suggest that these compounds may act as Selective Estrogen Receptors Modulators (SERMs), therefore holding significant potential for anticancer therapy.

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Section: Introductionmentioning

confidence: 99%

In Vitro, In Vivo and In Silico Analysis of the Anticancer and Estrogen-like Activity of Guava Leaf Extracts

Rizzo¹,

Longato²,

Ruiz³

et al. 2014

CMC

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“…The biosynthesis of these metabolites can be infl uenced by external factors like temperature, season, number of hours of sunlight, and soil composition (Martins et al, 1997;Freire et al, 2006;Demuner et al, 2011). In many cases genetic variability can also result in plant of different chemotypes (Castro et al, 2004;Silva et al, 2007;Lima et al, 2008). Therefore, the seasonal variation and anatomical study of S. trilobata is an important approach for the optimization of crop, post-harvest and extraction techniques, toward the potential commercial application of this natural resource.…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and histochemistry of Sphagneticola trilobata essential oil

Silva¹,

Barbosa²,

Demuner³

et al. 2012

Rev. bras. farmacogn.

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Anatomical and histochemical investigations of Sphagneticola trilobata (L.) Pruski, Asteraceae, secretory structures in leaves and stems and the seasonal variation of essential oils were carried out. Histochemical techniques enabled the specifi c location of the essential oil accumulation in the internal (canals) and external structures (trichomes). Histochemical analysis showed that the secretory trichomes produced steroids. The highest yield was obtained from plants collected in winter, when it was registered low temperature and precipitation. The essential oil was characterized by high percentage of hydrocarbon sesquiterpenes, hydrocarbon monoterpenes and low levels of oxygenated sesquiterpenes. The major components were germacrene D (11.9-35.8%), α-phellandrene (1.4-28.5%), α-pinene (7.3-23.8%), E-caryophyllene (4.6-19.0%), bicyclogermacrene (6.0-17.0%), limonene (1.8-15.1%) and α-humulene (4.0-11.6%). The percentage of most of the individual constituents present in S. trilobata essential oil changed signifi cantly during the months.

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“…The guava tree (Psidium guajava L.) is a fruit tree belonging to the Myrtaceae family that is indigenous to tropical regions of Central and South America (LIMA et al, 2010). Guava fruit has a high nutritional value and sensorial acceptance, and it is consumed both fresh and in processed forms.…”

Section: Introductionmentioning

confidence: 99%

Natural sparkling guava wine: volatile and physicochemical characterization

et al. 2017

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Although different tropical fruit species have been used in the development of fermented beverages, there are only few references in the literature to the production of natural sparkling wines from fruits other than grapes. In this sense, the objective of the present research was the development and physicochemical and volatile characterization of a natural sparkling guava wine produced by the champenoise method. Volatile compounds were identified by gas chromatography coupled to mass spectrometry using the headspace solid-phase microextraction (HS-SPME) technique on samples. Eighty-nine volatile compounds were detected, of which 51 were identified. Esters were the predominant class of volatile compounds (a total of 26), followed by alcohols (10), terpenes (9), ketones (3), and acids (3). Volatile compounds with possible odoriferous activity were reported in the beverage, including ethyl octanoate, ethyl 5-hexenoate, phenethyl acetate, (E)-β-damascenone, (E)-ethyl cinnamate, 2-methyl butyl acetate, 3-methylbutanol, ethyl 3-(E)-hexenoate, and methyl 5-hexenoate. Natural sparkling guava wine produced showed a complex composition of fruity and floral aromas. Furthermore, the use of the champenoise method, traditionally applied to grapes, enabled the manufacture of a natural sparkling guava wine with physicochemical characteristics equivalent to those of sparkling wines made from grapes.

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Composition of the essential oil from the leaves of tree domestic varieties and one wild variety of the guava plant (Psidium guajava L., Myrtaceae)

Cited by 24 publications

References 22 publications

In Vitro, In Vivo and In Silico Analysis of the Anticancer and Estrogen-like Activity of Guava Leaf Extracts

In Vitro, In Vivo and In Silico Analysis of the Anticancer and Estrogen-like Activity of Guava Leaf Extracts

Chemical composition and histochemistry of Sphagneticola trilobata essential oil

Natural sparkling guava wine: volatile and physicochemical characterization

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