Composition and antituberculosis activity of the volatile oil ofHeliotropium indicum Linn. growing in Phitsanulok, Thailand

Abstract

The volatile oil from the aerial parts of H. indicum was isolated by hydrodistillation and analysed by a combination of gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The essential oil was obtained in 0.004% yield as a light brown liquid. The major constituents of the volatile oil of H. indicum were phytol (49.1%), 1-dodecanol (6.4%) and β β β β β-linalool (3.0%). In addition, the volatile oil showed significant antituberculosis activity against Mycobacterium tuberculosis H37Ra in the Alamar blue assay system with an MIC of 20.8 µ µ µ µ µg/ml.

Constituents ofCajanus Cajan(L.) Millsp.,Moringa OleiferaLam.,Heliotropium IndicumL. andBidens PilosaL. from Nigeria

“…The main constituents were phenylacetaldehyde (22.2%), (E)-2-nonenal (8.3%), hexahydrofarnesylacetone (8.4%) and (E, Z)-2-nonadienal (6.1%). Except for the presence of linalool, borneol and tricosane, the present oil sample differed greatly from the literature report [11]. Phytol and 1-dodecanol, which constituted the bulk of the The chemical profile of each of the 49 constituents of the leaf and stem oils of B. pilosa revealed the abundance of sesquiterpene compounds ( Table 5).…”

GC-MS Analysis of Volatile Organic Constituents of Traditionally Used Medicinal Plants from the Western Ghats of India: Blumea lanceolaria (Roxb.) Druce., Heliotropium indicum L. and Triumfetta rhomboidea Jacq.

“…A comparison of essential oil constituents of H. indicum of this study with the compounds of plant growing in Thailand [19] was found to be completely different. Apart from this, the report from Nigeria grown H. indicum plant only three compounds viz., methyl salicylate (1.2%), (E)-β-ionone (1.9%) and eugenol (2.4%) [20] were found to be common compared to the present study.…”

“…The alkaloids viz., indicine [10], indicinine [15], helindicine, lycopsamine [16], pestalamide B, glycinamide,N-(1-oxooctadecyl) glycyl-Lalanylglycyl-L-histidyl [17] and indicine-N-oxide [18] have been isolated from H. indicum. The major volatile compounds phytol, 1-dodecanol, and β-linalool have been reported from Thailand and the oil showed significant anti-tuberculosis activity against Mycobacterium tuberculosis H37Ra in the Alamar blue assay system with a MIC of 20.8 μg/mL [19]. Another report from Nigeria reported phenylacetaldehyde, (E)-2-nonenal and (E,Z)-2-nonadienal and hexahydrofarnesylacetone [20] were the major constituents.…”

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“…The results revealed significant antituberculosis activity with an MIC of 20.8 µg/ml 37 . The antifungal activity 38 of the aqueous extract of fresh leaves against Fusarium oxyparum and antibacterial activity 39 41 .…”

“…In another experiment, the volatile oil isolated by hydrodistillation was analysed by a combination of GC-FID and GC-MS. The major constituents of the volatile oil were phytol (49.1%), 1-dodecanol (6.4%) and β-linalool (3.0%) 37 .…”