Composite large cell neuroendocrine carcinoma and adenocarcinoma of the common bile duct

Sato, Katsuaki; Waseda, Ryuichi; Tatsuzawa, Yasuhiko; Fujinaga, Hiroshi; Wakabayashi, Takayuki; Ueda, Yuzo; Katsuda, Shogo

doi:10.1136/jcp.2005.028019

Cited by 26 publications

(25 citation statements)

References 13 publications

(16 reference statements)

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“…Tumor markers, such as alpha fetoprotein, carcinoembryonic antigen, CA19-9 and CA125, are also non-specific. LCNEC is a rare type of CBD, and to our knowledge, only three previous cases have been described in the English-language literature (Table 1) [1][2][3] . Thus, this is the fourth reported case of LCNEC occurring in the extra bile duct.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, this is the fourth reported case of LCNEC occurring in the extra bile duct. The cases described by Sato et al [1] and Demoreuil et al [2] were MANECs (adenocarcinoma and LCNEC). Therefore, strictly speaking, our case is the second to report a pure LCNEC arising in the extra bile duct followed; the report of Sasatomi et al [3] was the first to report this type of lesion.…”

Section: Discussionmentioning

confidence: 99%

“…The patient did not exhibit abdominal tenderness or a palpable mass in the right upper quadrant of the abdomen. Sato et al [1] M/68 LCNEC + AD D 2 Resection and chemotherapy DD 3 mo Demoreuil et al [2] M/73 LCNEC + AD P 3 Resection and chemotherapy DD 12 mo Sasatomi et al [3] M …”

Section: Clinical Diagnosismentioning

confidence: 99%

“…LCNEC is a high-grade malignant neuroendocrine neoplasm. LCNEC of the CBD was first described by Sato et al [1] , and only two additional cases of LCNEC of the CBD have been reported to date [2,3] . The pathogeneses of NEC of the CBD remains unclear.…”

Section: Introductionmentioning

confidence: 99%

“…Histopathologically, reported LCNECs have been noted as pure forms or combined with adenocarcinoma or other tumors [2] . Given the invasive nature and aggressive biology of the tumor, the prognosis of patients with LCNEC of the CBD is poor [1] . Herein, we present a rare case of LCNEC of the CBD.…”

Section: Introductionmentioning

confidence: 99%

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Primary large cell neuroendocrine carcinoma in the common bile duct: First Asian case report

Park¹,

Moon²,

Ryu³

et al. 2014

WJG

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Large cell neuroendocrine carcinoma (LCNEC) in the biliary system is a poorly differentiated, high-grade neuroendocrine tumor. These tumors exhibit aggressive behavior and an increased tendency for early nodal and distant metastases. Herein, we report an unusual case of a pure primary LCNEC of the common bile duct (CBD). A 75-year-old female presented with nausea and jaundice. The patient underwent a CBD excision with lymph node dissection. Upon histological and immunohistochemical examination, the tumor exhibited pure large cell-type neuroendocrine features. Metastases were noted in two of the eight lymph nodes. The patient was administered adjuvant chemotherapy. The patient's cancer recurred 7 mo after surgery, and the patient died from liver failure 5 mo after recurrence. The prognosis of LCNEC of CBD remains poor despite curative resection and adjuvant chemotherapy. The role of additional therapies, such as multimodal treatment including radiation therapy, must be further studied to improve the prognoses of patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Clinical Diagnosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Primary large cell neuroendocrine carcinoma in the common bile duct: First Asian case report

Park¹,

Moon²,

Ryu³

et al. 2014

WJG

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Endoscopic ultrasound‐guided fine‐needle aspiration diagnosis of large cell neuroendocrine carcinoma of the gallbladder and common bile duct: Report of a case

Samad

Kaplan

Arain

et al. 2012

Diagnostic Cytopathology

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Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) allows a reliable and accurate diagnosis of neoplasms of the gallbladder and bile ducts. We report the cytopathologic findings of a case of large cell neuroendocrine carcinoma (LCNEC) of the gallbladder and extrahepatic bile ducts in a 67-year-old woman who presented with progressive abdominal pain and jaundice. EUS-FNA of the mass involving the common bile duct and of a porta hepatis lymph node showed abundant cellularity with tumor cells arranged singly and occasionally in tight and loose clusters and rosette-like structures in a background showing extensive necrotic debris. The tumor cells were predominantly plasmacytoid, showed a moderate amount of focally vacuolated cytoplasm and large round to oval hyperchromatic nuclei with prominent nucleoli, numerous mitoses, and apoptotic bodies. The differential diagnosis included poorly differentiated adenocarcinoma, lymphoma, melanoma, and poorly differentiated neuroendocrine carcinoma (NEC), large cell type. The tumor cells were strongly and diffusely positive for cytokeratin AE1/AE3, CD56, synaptophysin, and chromogranin and showed a very high proliferative fraction on Ki67 staining, supporting the diagnosis of a high-grade NEC. Due to the large size of the neoplastic cells, moderate amounts of cytoplasm and prominent nucleoli, a diagnosis of LCNEC was made on the EUS-FNA sample. Despite the prompt institution of chemotherapy, the patient died shortly thereafter and the diagnosis was confirmed at autopsy. This is to our knowledge the first case of LCNEC of the gallbladder and bile ducts diagnosed by EUS-FNA.

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Neuroendocrine Tumors of the Hepatobiliary Tract

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Neuroendocrine neoplasms of the hepatobiliary tract are rare neoplasms that derive from neuroendocrine cells located in the bile duct mucosa and several compartments of the liver proper. These neoplasms are divided into neuroendocrine tumors (NET) and neuroendocrine carcinomas (NEC). Well-differentiated NET (G1) have previously been termed carcinoid tumors. Most of neuroendocrine neoplasms that are known from extrahepatic organs and tissues also develop in the hepatobiliary tract, except tumors that originate from distinct specialized neuroendocrine/endocrine cell types that do not exist in this organ. The bile ducts are a well-known primary location of welldifferentiated carcinoid-type NETs. Neuroendocrine carcinomas can also develop in bile ducts and the liver, but are unusual lesions. Intriguing primary neuroendocrine neoplasms of the liver are undifferentiated small cell and large cell carcinomas, which have to be distinguished from the more common liver metastases of extrahepatic tumors with this morphology.

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Composite large cell neuroendocrine carcinoma and adenocarcinoma of the common bile duct

Cited by 26 publications

References 13 publications

Primary large cell neuroendocrine carcinoma in the common bile duct: First Asian case report

Primary large cell neuroendocrine carcinoma in the common bile duct: First Asian case report

Endoscopic ultrasound‐guided fine‐needle aspiration diagnosis of large cell neuroendocrine carcinoma of the gallbladder and common bile duct: Report of a case

Neuroendocrine Tumors of the Hepatobiliary Tract

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