Composite hemangioendothelioma of the spleen with multiple metastases

Li, Weiwei; Liang, Pan; Zhao, Hui; Zhang, Yan Xing; Liu, Yi Yang; Jin, Gao

doi:10.1097/md.0000000000025846

Cited by 8 publications

(9 citation statements)

References 35 publications

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“…Composite hemangioendothelioma (CHE) was first described in 2000 by Nayler et al [ 2 , 5 , 7 – 9 ]. It is a rare intermediate-grade (occasionally metastatic) vascular tumor that is most often seen in young adults (mean age 42 years) but can present at any age from birth to 75 years, with women being the most common [ 5 , 7 – 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is defined as a locally aggressive, occasionally metastatic vascular tumor containing a mixture of histologically distinct components [ 4 ]. CHE is very rare, with about 59 cases reported in the English literature so far [ 5 ]. Herein, we report two cases of CHE, the first case occurred in the left pubis (female, 21 years old), and the second case is a patient post-resection of CHE in the manubrium sterni 10 years ago [ 1 ], who developed of new lesions in the left ilium and T6, T12 vertebra (male, 66 years old).…”

Section: Introductionmentioning

confidence: 99%

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Composite hemangioendothelioma- report of two cases located in bone and review of the literature

Deng,

2023

BMC Musculoskelet Disord

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Background Composite hemangioendothelioma (CHE) is a rare intermediate-grade vascular tumor characterized by a complex histologic component. It occasionally metastasizes, but local recurrence is not uncommon. CHE is mainly located in the extremities’ distal dermis and subcutaneous soft tissues. It is rarely located in the bone. We report here two cases originally occurred in bone. Case presentation The first case of CHE occurred solely on the left pubis. The second case is a patient post-resection of CHE in the manubrium sterni 10 years ago [1], who presented with multiple lesions in the left ilium and T6, T12 vertebra. All these lesions in the two cases showed osteolytic bone destruction on computed tomography (CT) scans and showed relatively high signal intensity on the fat-suppressed sequences of T2-weighted magnetic resonance (MR) images and isointense signal intensity on T1-weighted MR images. After injection of contrast agent (Gd-DTPA), the lesions showed inhomogeneous enhancement. 2-deoxy-2 [F-18] fluoro-D-glucose positron emission tomography-computed tomography (18FDG PET-CT) showed increased FDG uptake in these osteolytic bone destruction areas with SUVmax around 5.0. Both patients underwent surgery. Lesions in the left pubis and left ilium were confirmed by postoperative pathology while lesions on the vertebrae were only biopsied, not surgically resected. The first patient had no recurrence or metastasis in 5 years after surgery. The second patient had surgery recently and is still being followed up. Conclusions CHE occurring in bone is rarely reported. Our report provides more detailed information on the diagnosis of CHE. Given that CHE is locally aggressive and occasionally metastatic, PET-CT may be helpful in staging and follow-up.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Composite hemangioendothelioma- report of two cases located in bone and review of the literature

Deng,

2023

BMC Musculoskelet Disord

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“…Benign, neutral, and malignant components are histologically mixed with each other, as in our case, making it difficult to identify those components. So far, fewer than 60 clinical cases have been reported [Li 2021]. It commonly has occurred as long-standing lesions in the dermis and subcutis of the extremities but also increasingly has been reported at other sites, including the oral cavity, mediastinum, manubrium sterni, and in viscera such as the kidney and spleen [Chen 2012].…”

Section: Discussionmentioning

confidence: 99%

The First Case of Composite Hemangioendothelioma in The Heart

Zhang

Wang

2022

HSF

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Composite hemangioendothelioma (CHE) is an extremely rare vascular neoplasm that is characterized by an admixture of benign, low-grade malignant, and malignant vascular components. It is usually located superficially in the dermis and subcutis of the extremities, and other sites involved include the head and neck region, oral mucosa, and viscera of the kidney and spleen. CHE has a low-grade malignant potential because it is locally aggressive. Here, we report a case of CHE in the heart in a 46-year-old man, who presented with a palpable mass arising from his right ventricle. Echocardiogram imaging revealed a 13.3 × 14.2 mm mass with high-signal intensity. Excision was performed, and microscopic examination revealed a heterogeneous mixture of vascular components, consisting of spindle-cell hemangioma, retiform hemangioendothelioma, and epithelioid-like hemangioendothelioma areas. To our knowledge, this is the first report on the behavior of this distinctive vascular neoplasm occurring in the right ventricle. Due to the unclear biological behavior of CHE in the heart and the paucity of cases, no further therapy was undertaken despite the risk of local recurrence and distant metastasis. The result of a six-month follow-up after surgery was disease-free.

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“…A review of the literature identified a total of 52 patients with CHE (mean age: 42.5 years) reported in the English language, including a 48-year-old woman with CHE in the spine [12]. Most patients underwent surgical treatment.…”

Section: Et Al Reported Thatmentioning

confidence: 99%

“…Most patients underwent surgical treatment. Radiotherapy, chemotherapy, electron beam irradiation, interferon-α 2b, and thalidomide have also been described as effective for CHE with or without resection, although are less common than surgery [12][13][14][15][16][17]. Since CHE in the spine or bones is rare, there remains no consensus on its treatment [13,14].…”

Section: Et Al Reported Thatmentioning

confidence: 99%

Composite hemangioendothelioma in the cervical spine with kaposiform hemangioendothelioma features in an elderly patient: a case report

et al. 2022

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Background Composite hemangioendothelioma (CHE) is an intermediate group of tumors with features between hemangioma and angiosarcoma both histologically and biologically. CHE is predominant in young and middle-aged adults, but very infrequently affects the spine. We describe the case of primary CHE in the cervical spine exhibiting kaposiform hemangioendothelioma (KHE)-like components that was associated with cervical myelopathy with vertebral body destruction in an elderly woman. We retrospectively reviewed the case of a primary cervical spinal tumor, diagnosed as CHE with KHE-like components in pathological findings, associated with cervical myelopathy and cervical vertebral body destruction. Case presentation An 80-year-old woman presented with progressive cervical myelopathy caused by a cervical spine tumor. Preoperative cervical MRI revealed a neoplastic lesion invading the cervical spine that strongly compressed the spinal cord, causing right upper-limb paralysis. We performed partial tumor resection along with posterior decompression and fixation. Postoperatively, pathological findings showed that the tumor was CHE with KHE-like features. Following radiotherapy, no recurrences have been observed in 21 months. Conclusions This is the first report of CHE with features of KHE in the spine of an elderly patient. Posterior decompression and fusion of the cervical spine and subsequent radiotherapy resulted in a good outcome.

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Composite hemangioendothelioma of the spleen with multiple metastases

Cited by 8 publications

References 35 publications

Composite hemangioendothelioma- report of two cases located in bone and review of the literature

Composite hemangioendothelioma- report of two cases located in bone and review of the literature

The First Case of Composite Hemangioendothelioma in The Heart

Composite hemangioendothelioma in the cervical spine with kaposiform hemangioendothelioma features in an elderly patient: a case report

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