Composite Hemangioendothelioma

Mahmoudizad, Rod; Samrao, Aman; Bentow, Jason; Peng, Shi‐Kaung; Bhatia, Neil

doi:10.1309/ajcpxek50yprndhx

Cited by 22 publications

(13 citation statements)

References 21 publications

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“…MRI can clearly depict muscle and soft tissue lesions, but it is not as good as CT for bone invasion and lymph node metastasis. CT revealed one or more heterogeneous and contrast-enhanced masses, with or without lobulation, lymphadenopathy, calcification [4,6,7,10,12,22,26,28,30] . CT of a CHE arising from the spleen showed a large protruding cystic mass in the spleen with multiple liver nodules and supraclavicular lymphadenopathy, which was reported by Yoda et al [7] In our case, CT displayed multiple lobulated lightly enhanced or unenhanced masses of the spleen with massive calcifications.…”

Section: Discussionsupporting

confidence: 75%

“…CT revealed one or more heterogeneous and contrast-enhanced masses, with or without lobulation, lymphadenopathy, calcification. [4,6,7,10,12,22,26,28,30] CT of a CHE arising from the spleen showed a large protruding cystic mass in the spleen with multiple liver nodules and supraclavicular lymphadenopathy, which was reported by Yoda et al [7] In our case, CT displayed multiple lobulated lightly enhanced or unenhanced masses of the spleen with massive calcifications. In addition, multiple metastases of the liver, ribs, lungs, and vertebral bodies were detected.…”

Section: Discussionsupporting

confidence: 69%

“…Due to the low metastatic frequency and the low-grade malignant biologic behavior of the tumors patients always live with the disease for several years before the diagnosis was proposed [3,13] . The clinical features and treatment of all isolated patients reported in the literature are illustrated in Table 2 [3–30] . The present case was a primary tumor in the spleen with multiple metastases, which was only one case reported before [7] .…”

Section: Discussionmentioning

confidence: 81%

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Composite hemangioendothelioma of the spleen with multiple metastases

Liang

Zhao

et al. 2021

Medicine

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Composite hemangioendothelioma (CHE) is a rare vascular neoplasm of intermediate malignant potential. Only 52 cases have been reported in the English literature, and one case previously reported occurred in the spleen. The purpose of our study was to report a 65-year-old man diagnosed as CHE primary arising from the spleen with multiple metastases.Clinical and imaging features, laboratory tests, and pathological results about CHE were described in detail in this study.The patient presented with multiple lesions in bilateral lungs and spleen that had been incidentally detected by computed tomography (CT). Except for thrombocytopenia, other laboratory tests were not significant. The CT scan of the abdomen revealed multiple round-like and irregularly mixed density masses with unclear borders in enlarged spleen. And contrast enhancement showed mild heterogeneous enhancement. CT scan also showed widespread liver, ribs, lungs, and vertebral bodies metastases. This diagnosis was confirmed by histopathological examination. The patient underwent splenectomy and still survives with tumors after six months followed-up.Due to the lack of specificity of clinical features and laboratory tests, it is necessary to combine imaging features and pathological findings to make a correct diagnosis.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 81%

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Composite hemangioendothelioma of the spleen with multiple metastases

Liang

Zhao

et al. 2021

Medicine

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“…The lesion of our study was unique since it involved all of the scalp surface, eyelids, and face and the swelling of the eyelids resulted in complete closure of the eyelids on both sides, which impaired the patient’s vision; however, the patient’s eye examination was normal. It seems that the CHE is a lesion composed of a mixture of different patterns, which can vary from tumor to tumor [ 7 , 8 ]. In the CHE, each component has different characteristics, and the ratio and distribution of each component are diverse in each lesion.…”

Section: Discussionmentioning

confidence: 99%

Composite hemangioendothelioma of the forehead and right eye; a case report

et al. 2017

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BackgroundHemangioendothelioma includes several types of vascular neoplasms, as well as both benign and malignant growth.Case presentationThis study evaluated a case of a 78-year-old female diagnosed with composite hemangioendothelioma (CHE). This patient had an 18-month history of painless inflammatory lesions and erythema on the left forehead and right upper eyelid. The clinical and pathologic characteristics of the CHE were evaluated in the present study.ConclusionThe evidence of the coexistence of variable components of the CHE in our study emphasized the importance of distinctive morphology and biology, and should be considered in the differential diagnosis of other vascular lesions.

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“…Prevention of venous thromboembolism and pulmonary thromboembolism (PTE) needs anticoagulant therapy because of increased mortality [ 325 ]. Composite hemangioendothelioma (CHE) is an intermediate-grade vascular tumor which is a common vascular tumors exhibiting composite variants [ 326 ]. Cerebral microbleeds (CMBs) are associated with increased risk of stroke and poor cognition.…”

Section: Future Biomarkers Of Cvd Risksmentioning

confidence: 99%

Emerging Risk Biomarkers in Cardiovascular Diseases and Disorders

2015

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Present review article highlights various cardiovascular risk prediction biomarkers by incorporating both traditional risk factors to be used as diagnostic markers and recent technologically generated diagnostic and therapeutic markers. This paper explains traditional biomarkers such as lipid profile, glucose, and hormone level and physiological biomarkers based on measurement of levels of important biomolecules such as serum ferritin, triglyceride to HDLp (high density lipoproteins) ratio, lipophorin-cholesterol ratio, lipid-lipophorin ratio, LDL cholesterol level, HDLp and apolipoprotein levels, lipophorins and LTPs ratio, sphingolipids, Omega-3 Index, and ST2 level. In addition, immunohistochemical, oxidative stress, inflammatory, anatomical, imaging, genetic, and therapeutic biomarkers have been explained in detail with their investigational specifications. Many of these biomarkers, alone or in combination, can play important role in prediction of risks, its types, and status of morbidity. As emerging risks are found to be affiliated with minor and microlevel factors and its diagnosis at an earlier stage could find CVD, hence, there is an urgent need of new more authentic, appropriate, and reliable diagnostic and therapeutic markers to confirm disease well in time to start the clinical aid to the patients. Present review aims to discuss new emerging biomarkers that could facilitate more authentic and fast diagnosis of CVDs, HF (heart failures), and various lipid abnormalities and disorders in the future.

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Composite Hemangioendothelioma

Abstract: This unique case presentation is representative of the variability seen in the presentation of CHE and highlights the importance of considering CHE on the clinical and histologic differential of vascular tumors.

Cited by 22 publications

References 21 publications

Composite hemangioendothelioma of the spleen with multiple metastases

Composite hemangioendothelioma of the spleen with multiple metastases

Composite hemangioendothelioma of the forehead and right eye; a case report

Emerging Risk Biomarkers in Cardiovascular Diseases and Disorders

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