Complications after breast reconstruction with alloplastic material in breast cancer patients submitted or not to post mastectomy radiotherapy

Stuart, Silvia Radwanski; Munhoz, Alexandre Mendonça; Chaves, Cristiane L.G.; Montag, Eduardo; Cordeiro, Thalita C.S; Fuzisaki, Tatiana Taba; Marta, Gustavo Nader; Carvalho, Helotônio

doi:10.5603/rpor.a2021.0087

Cited by 2 publications

(3 citation statements)

References 34 publications

(42 reference statements)

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“…However, Stuart SR compared the effect of radiation therapy on implant-related complications in breast cancer patients undergoing IBBR, 23.9% of patients who received PMRT had acute complications, 5.4% had late complications, 30.9% of non-irradiated patients had acute complications and 2.4% had late complications. Radiation therapy resulted in a higher, but not statistically significant risk of late complications compared to non-irradiated patients ( 28 ). It had also been suggested that age over 50 years and a larger mastectomy weight were associated with a higher risk of acute complications, but not with PMRT ( 29 ).…”

Section: Discussionmentioning

confidence: 87%

“…Additionally, we generally believed that radiotherapy was associated with higher implant-related complications in the past (27). However, Stuart SR compared the effect of radiation therapy on implant-related complications in breast cancer patients undergoing IBBR, 23.9% of patients who received PMRT had acute complications, 5.4% had late complications, 30.9% of nonirradiated patients had acute complications and 2.4% had late complications.…”

Section: Discussionmentioning

confidence: 99%

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Radiotherapy dosimetry and radiotherapy related complications of immediate implant-based reconstruction after breast cancer surgery

Zhang,

Ye,

Teng

et al. 2023

Front. Oncol.

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BackgroundsThe impact of immediate implant-based breast reconstruction (IBBR) on the delivery of radiotherapy plans remains controversial. This study aimed to compare the differences in radiotherapy dosimetry, complications of radiotherapy, and quality of life in patients who underwent modified radical mastectomy combined with or without IBBR.MethodsWe retrospectively collected 104 patients with breast cancer who underwent intensity-modulated radiation therapy after modified radical mastectomy with IBBR (n =46) or not (n =58) from January 2017 to December 2021. The dosimetric differences in radiotherapy of planning target volume (PTV) and organs at risk and the differences in complications of radiotherapy between the two groups were compared. We also applied the functional assessment of cancer therapy-breast cancer (FACT-B) score to compare the difference in quality of life. The chi-square test and independent samples t-test were used to analyze the above data.ResultsIBBR group was associated with higher PTV volumes, PTV D98, V95, and lower PTV Dmean, D2 compared with the non-reconstruction group (P<0.05). IBBR group also had lower radiotherapy dosimetric parameters in the ipsilateral lung and the heart of left breast cancer patients. The differences in the rates of radiation pneumonia (RP) and radiation dermatitis (RD) between the two groups were not statistically significant (P > 0.05). Moreover, FACT-B scores at 6 months after radiotherapy in patients with IBBR were higher than those without reconstruction (P < 0.05).ConclusionPatients with IBBR achieved better radiation dosimetry distribution and higher quality of life without more complications of radiotherapy.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Radiotherapy dosimetry and radiotherapy related complications of immediate implant-based reconstruction after breast cancer surgery

Zhang,

Ye,

Teng

et al. 2023

Front. Oncol.

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“…In recent years, immediate breast reconstruction with prosthesis or expander, after mastectomy or conservative surgery, has steadily increased [ 3 ], being valuable in the treatment of breast cancer, as well as in the plastic surgery practice, due to its potential impact on both the morpho-functional and aesthetic type of the breast and the relative quality of life [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

A Machine Learning Approach for Predicting Capsular Contracture after Postmastectomy Radiotherapy in Breast Cancer Patients

et al. 2023

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In recent years, immediate breast reconstruction after mastectomy surgery has steadily increased in the treatment pathway of breast cancer (BC) patients due to its potential impact on both the morpho-functional and aesthetic type of the breast and the quality of life. Although recent studies have demonstrated how recent radiotherapy techniques have allowed a reduction of adverse events related to breast reconstruction, capsular contracture (CC) remains the main complication after post-mastectomy radio-therapy (PMRT). In this study, we evaluated the association of the occurrence of CC with some clinical, histological and therapeutic parameters related to BC patients. We firstly performed bivariate statistical tests and we then evaluated the prognostic predictive power of the collected data by using machine learning techniques. Out of a sample of 59 patients referred to our institute, 28 patients (i.e., 47%) showed contracture after PMRT. As a result, only estrogen receptor status (ER) and molecular subtypes were significantly associated with the occurrence of CC after PMRT. Different machine learning models were trained on a subset of clinical features selected by a feature importance approach. Experimental results have shown that collected features have a non-negligible predictive power. The extreme gradient boosting classifier achieved an area under the curve (AUC) value of 68% and accuracy, sensitivity, and specificity values of 68%, 64%, and 74%, respectively. Such a support tool, after further suitable optimization and validation, would allow clinicians to identify the best therapeutic strategy and reconstructive timing.

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Complications after breast reconstruction with alloplastic material in breast cancer patients submitted or not to post mastectomy radiotherapy

Cited by 2 publications

References 34 publications

Radiotherapy dosimetry and radiotherapy related complications of immediate implant-based reconstruction after breast cancer surgery

Radiotherapy dosimetry and radiotherapy related complications of immediate implant-based reconstruction after breast cancer surgery

A Machine Learning Approach for Predicting Capsular Contracture after Postmastectomy Radiotherapy in Breast Cancer Patients

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