Compliance with Sulfonylureas in a Health Maintenance Organization: A Pharmacy Record–Based Study

Venturini, Francesca; Nichol, Michael B.; Sung, Jennifer; Bailey, K. L.; Cody, Marisue; McCombs, Jeffrey S.

doi:10.1345/aph.18198

Cited by 91 publications

(82 citation statements)

References 23 publications

(23 reference statements)

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“…Fasting plasma glucose and HbA 1c levels have been noted to drift upwards subsequent to long-term treatment with sulfonylureas, metformin, or diet and exercise (5). Similar results were observed in another claims database analysis, where regimen complexity and low self-reported compliance were also seen for sulfonylurea therapy (7). This lack of glycemic control places diabetic patients at high risk for accelerated disease progression and its sequelae.…”

supporting

confidence: 82%

Utilization of Oral Hypoglycemic Agents in a Drug-Insured U.S. Population

Boccuzzi¹,

Wogen²,

Fox³

et al. 2001

Diabetes Care

164

101

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OBJECTIVE -Clinical trials provide information regarding the safety and efficacy of medications used to manage type 2 diabetes but do not elucidate drug effectiveness in a typical managed care environment. The aim of this study was to characterize "real-world" drug utilization patterns from both a prescriber and a patient perspective.RESEARCH DESIGN AND METHODS -We conducted a retrospective analysis of a large administrative pharmacy claims database, using data on continuously pharmacy benefiteligible members prescribed oral hypoglycemic agents (OHAs).RESULTS -The 12-month persistence rate for the OHA cohort was low, ranging from 31% for ␣-glucosidase inhibitors to 60% for metformin; compliance rates varied between 70 and 80%. During the first 12 months of therapy, 36% of the patients remaining on therapy at 12 months had one or more therapy modifications. The mean number of therapy changes increased with the length of patient follow-up, with more than half of all patients experiencing at least one therapy change over the duration of follow-up.CONCLUSIONS -These findings document the wide variation in utilization patterns associated with pharmacological management of type 2 diabetes, suggesting that opportunity exists to optimize its pharmacological management.

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supporting

confidence: 82%

Utilization of Oral Hypoglycemic Agents in a Drug-Insured U.S. Population

Boccuzzi¹,

Wogen²,

Fox³

et al. 2001

Diabetes Care

164

101

View full text Add to dashboard Cite

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“…22,43 Although medication adherence was assessed by an instrument that has not been validated for use in our setting, especially in the format that uses fewer items (e.g., the 4-item instead of 8-item version of the Morisky scale), this instrument has been validated and was found to be reliable and widely used in a variety of medication adherence studies. [49][50][51][52][53] Furthermore, Kripilani et al (2009) used the Morisky Scale as a "gold standard" against which to test a new adherence measurement instrument. 54 Research has indicated that adherence to medication in type 2 diabetes is poor and is considered as one of the main barriers to the benefit of optimal diabetes care and a major cause of unnecessary hospitalization.…”

Section: Randomized Controlled Trial Of Clinical Pharmacy Management mentioning

confidence: 99%

Randomized Controlled Trial of Clinical Pharmacy Management of Patients with Type 2 Diabetes in an Outpatient Diabetes Clinic in Jordan

Jarab¹,

Alqudah²,

Mukattash³

et al. 2012

JMCP

150

302

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BACKGROUND: Glycemic goals (hemoglobin A1c < 7%) are often not achieved in patients with type 2 diabetes despite the availability of many effective treatments and the documented benefits of glycemic control in the reduction of long-term microvascular and macrovascular complications. Several studies have established the important positive effects of pharmacist-led management on achieving glycemic control and other clinical outcomes in patients with diabetes. Diabetes prevalence and mortality are increasing rapidly in Jordan. Nevertheless, clinical pharmacists in Jordan do not typically provide pharmaceutical care; instead, the principal responsibilities of pharmacists in Jordan are dispensing and marketing of medical products to physicians.

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“…It has good reliability and validity. 44,45 This scale asks patients to respond ''yes'' or ''no'' to a set of four questions. A positive response to any question indicates a problem with adherence with a total possible score of 4; higher values indicate poorer adherence.…”

Section: Medication Adherencementioning

confidence: 99%

Associations Between Health Literacy, Diabetes Knowledge, Self-Care Behaviors, and Glycemic Control in a Low Income Population with Type 2 Diabetes

Bains

Egede

2011

Diabetes Technology & Therapeutics

241

225

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Objective: This study assessed associations among health literacy, diabetes knowledge, self-care, and glycemic control in a low income, predominately minority population with type 2 diabetes. Methods: One hundred twenty-five adults with diabetes were recruited from a primary care clinic. Subjects completed validated surveys to measure health literacy, diabetes knowledge, and self-care (medication adherence, diet, exercise, blood sugar testing, and foot care). Hemoglobin A1c values were extracted from the medical record. Spearman's correlation and multiple linear regression were used to assess the relationship among health literacy, diabetes knowledge, self-care, and glycemic control controlling for covariates. Results: Cronbach's a was 0.95 for the Revised Rapid Estimate of Adult Literacy in Medicine. The majority of the sample was <65 years old (50.7%), female (72.5%), and African American (71.4%), had less than a high school education (68.2%) and a household income <$15,000 (64.2%), and reported their health status as worse than last year (73.9%). In adjusted models that examined the associations among health literacy, diabetes knowledge, medication adherence, and self-care, health literacy was only significantly associated with diabetes knowledge (b ¼ 0.55; 95% confidence interval [CI] 0.29, 0.82). In the final adjusted model for independent factors associated with glycemic control, both diabetes knowledge (b ¼ 0.12; 95% CI 0.01, 0.23) and perceived health status (b ¼ 1.14; 95% CI 0.13, 2.16) were significantly associated with glycemic control, whereas health literacy was not associated with glycemic control (b ¼ À0.03; 95% CI À0.19, 0.13). Conclusions: Diabetes knowledge and perceived health status are the most important factors associated with glycemic control in this population. Health literacy appears to exert its influence through diabetes knowledge and is not directly related to self-care or medication adherence.

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Compliance with Sulfonylureas in a Health Maintenance Organization: A Pharmacy Record–Based Study

Abstract: Our results suggest that factors found to be associated with noncompliant behavior (e.g., being a newly treated patient, self-reported compliance, regimen complexity) can be assessed by physicians and pharmacists as a routine practice.

Cited by 91 publications

References 23 publications

Utilization of Oral Hypoglycemic Agents in a Drug-Insured U.S. Population

Utilization of Oral Hypoglycemic Agents in a Drug-Insured U.S. Population

Randomized Controlled Trial of Clinical Pharmacy Management of Patients with Type 2 Diabetes in an Outpatient Diabetes Clinic in Jordan

Associations Between Health Literacy, Diabetes Knowledge, Self-Care Behaviors, and Glycemic Control in a Low Income Population with Type 2 Diabetes

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