Compliance of the proximal stomach and dyspeptic symptoms in patients with type I diabetes mellitus

Measurement of gastric emptying by radiopaque markers in patients with diabetes: correlation with scintigraphy and upper gastrointestinal symptoms

“…If the test shows delayed gastric emptying, no further test seems necessary, whereas a normal result does not exclude gastroparesis, and if the clinical suspicion of gastroparesis remains, a scintigraphic test should be advocated. Consistent with several previous studies, we also demonstrated modest associations between GI symptom severity and gastric emptying, indicating that other mechanisms are also involved in symptom perception in patients with diabetes 29–32 …”

“…Consistent with previous studies, we found only a modest association between GI symptoms and gastric emptying 4,5 . Several other mechanisms than delayed gastric emptying may be involved in symptom generation in patients with diabetes, such as visceral hypersensitivity, 30 abnormal gastric compliance and accommodation, 32 central nervous system abnormalities, 31 psychological comorbidity, 29 and effects of pharmacological agents 41 . In our study, results from scintigraphy correlated with upper GI symptoms in subjects with insulin‐treated diabetes, but not with ROM emptying.…”

Measurement of gastric emptying by radiopaque markers in patients with diabetes: correlation with scintigraphy and upper gastrointestinal symptoms

“…If the test shows delayed gastric emptying, no further test seems necessary, whereas a normal result does not exclude gastroparesis, and if the clinical suspicion of gastroparesis remains, a scintigraphic test should be advocated. Consistent with several previous studies, we also demonstrated modest associations between GI symptom severity and gastric emptying, indicating that other mechanisms are also involved in symptom perception in patients with diabetes 29–32 …”

“…Consistent with previous studies, we found only a modest association between GI symptoms and gastric emptying 4,5 . Several other mechanisms than delayed gastric emptying may be involved in symptom generation in patients with diabetes, such as visceral hypersensitivity, 30 abnormal gastric compliance and accommodation, 32 central nervous system abnormalities, 31 psychological comorbidity, 29 and effects of pharmacological agents 41 . In our study, results from scintigraphy correlated with upper GI symptoms in subjects with insulin‐treated diabetes, but not with ROM emptying.…”

Lower postprandial gastric volume response in diabetic patients with vagal neuropathy

“…The suggestion is consistent with the high gastric compliance in these patients also shown by Samsom et al. 27 Low gastric tone has also been demonstrated in patients with gastroparesis following vagotomy. 26,29 Theoretically, the low MDP may have contributed to the lower postprandial volume responses in diabetics simply because the distending pressure was lower in these patients than in controls.…”

CCR2 upregulation in DRG neurons plays a crucial role in gastric hyperalgesia associated with diabetic gastropathy

“…In spite of a great deal of research having been conducted on gastric emptying, studies of gastric sensations are rare: only two investigations have reported an increased sensory response to gastric distension in type 1 DM patients compared with healthy controls. 35,36 Similar findings were observed in this study: that DM rats had higher sensitivity to GD than did age-matched CT rats (Figure 3(b)), and furthermore, that hypersensitive VMR to GD in DM rats was partially but significantly reversed for at least 2 h by intrathecal injection of the CCR2 antagonist INCB3344 (1 mM and 0.1 mM) (Figure 4). It was consistent with other neuropathic pain studies in which mechanical and thermal hyperalgesia after peripheral nerve injury were inhibited by CCR2 antagonists.…”

Measurement of gastric emptying by radiopaque markers in patients with diabetes: correlation with scintigraphy and upper gastrointestinal symptoms

“…If the test shows delayed gastric emptying, no further test seems necessary, whereas a normal result does not exclude gastroparesis, and if the clinical suspicion of gastroparesis remains, a scintigraphic test should be advocated. Consistent with several previous studies, we also demonstrated modest associations between GI symptom severity and gastric emptying, indicating that other mechanisms are also involved in symptom perception in patients with diabetes 29–32 …”

“…Consistent with previous studies, we found only a modest association between GI symptoms and gastric emptying 4,5 . Several other mechanisms than delayed gastric emptying may be involved in symptom generation in patients with diabetes, such as visceral hypersensitivity, 30 abnormal gastric compliance and accommodation, 32 central nervous system abnormalities, 31 psychological comorbidity, 29 and effects of pharmacological agents 41 . In our study, results from scintigraphy correlated with upper GI symptoms in subjects with insulin‐treated diabetes, but not with ROM emptying.…”

Lower postprandial gastric volume response in diabetic patients with vagal neuropathy

“…The suggestion is consistent with the high gastric compliance in these patients also shown by Samsom et al. 27 Low gastric tone has also been demonstrated in patients with gastroparesis following vagotomy. 26,29 Theoretically, the low MDP may have contributed to the lower postprandial volume responses in diabetics simply because the distending pressure was lower in these patients than in controls.…”

CCR2 upregulation in DRG neurons plays a crucial role in gastric hyperalgesia associated with diabetic gastropathy

“…In spite of a great deal of research having been conducted on gastric emptying, studies of gastric sensations are rare: only two investigations have reported an increased sensory response to gastric distension in type 1 DM patients compared with healthy controls. 35,36 Similar findings were observed in this study: that DM rats had higher sensitivity to GD than did age-matched CT rats (Figure 3(b)), and furthermore, that hypersensitive VMR to GD in DM rats was partially but significantly reversed for at least 2 h by intrathecal injection of the CCR2 antagonist INCB3344 (1 mM and 0.1 mM) (Figure 4). It was consistent with other neuropathic pain studies in which mechanical and thermal hyperalgesia after peripheral nerve injury were inhibited by CCR2 antagonists.…”

Measurement of gastric emptying by radiopaque markers in patients with diabetes: correlation with scintigraphy and upper gastrointestinal symptoms

“…If the test shows delayed gastric emptying, no further test seems necessary, whereas a normal result does not exclude gastroparesis, and if the clinical suspicion of gastroparesis remains, a scintigraphic test should be advocated. Consistent with several previous studies, we also demonstrated modest associations between GI symptom severity and gastric emptying, indicating that other mechanisms are also involved in symptom perception in patients with diabetes 29–32 …”

“…Consistent with previous studies, we found only a modest association between GI symptoms and gastric emptying 4,5 . Several other mechanisms than delayed gastric emptying may be involved in symptom generation in patients with diabetes, such as visceral hypersensitivity, 30 abnormal gastric compliance and accommodation, 32 central nervous system abnormalities, 31 psychological comorbidity, 29 and effects of pharmacological agents 41 . In our study, results from scintigraphy correlated with upper GI symptoms in subjects with insulin‐treated diabetes, but not with ROM emptying.…”

Lower postprandial gastric volume response in diabetic patients with vagal neuropathy

“…The suggestion is consistent with the high gastric compliance in these patients also shown by Samsom et al. 27 Low gastric tone has also been demonstrated in patients with gastroparesis following vagotomy. 26,29 Theoretically, the low MDP may have contributed to the lower postprandial volume responses in diabetics simply because the distending pressure was lower in these patients than in controls.…”

CCR2 upregulation in DRG neurons plays a crucial role in gastric hyperalgesia associated with diabetic gastropathy

“…In spite of a great deal of research having been conducted on gastric emptying, studies of gastric sensations are rare: only two investigations have reported an increased sensory response to gastric distension in type 1 DM patients compared with healthy controls. 35,36 Similar findings were observed in this study: that DM rats had higher sensitivity to GD than did age-matched CT rats (Figure 3(b)), and furthermore, that hypersensitive VMR to GD in DM rats was partially but significantly reversed for at least 2 h by intrathecal injection of the CCR2 antagonist INCB3344 (1 mM and 0.1 mM) (Figure 4). It was consistent with other neuropathic pain studies in which mechanical and thermal hyperalgesia after peripheral nerve injury were inhibited by CCR2 antagonists.…”