Complexes of pectin polysaccharide with acetylsalicylic acid

Минзанова, С. Т.; Миронов, В. Ф.; Vyshtakalyuk, A. B.; Tsepaeva, O. V.; Миронова, Л. Г.; Рыжкина, И. С.; Муртазина, Л. И.; Gubaidullin, А. Т.

doi:10.1134/s0012500813090048

Cited by 7 publications

(6 citation statements)

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“…In rats treated with ASA at the dose of 40 mg/kg, the mucosa in both body and pyloric areas of the gastric was hyperemic DISCUSSION: Thus, the results of a comparative evaluation of the anti-inflammatory activity and the ulcerogenic effect of the molecular complex of pectin with acetylsalicylic acid (P-ASA) and the individual substance acetylsalicylic acid (ASA) showed that P-ASA at the maximum therapeutic dose of 400 mg/kg has almost no ulcerogenic effect, in contrast to ASA in an equimolar dose of 40 mg/kg, causing hyperemia of the gastric mucosa and increased stellate pattern. These results are comparable with our previous data on the comparative assessment of the toxicity of P-ASA and ASA 5,6 as well as with literature data confirming the ability of pectin to reduce the toxic and side effects of biologically active and medicinal substances during complexation 8 . This property of pectin complexes may be due to the enveloping effect of pectin, as well as the gradual release and absorption of the active drug component into the gastrointestinal tract.…”

Section: Influence Of Preparations On Catalase Activity and Malondialsupporting

confidence: 92%

“…dicarboxylic acids succinic and fumaric 4 , by complexation process, as well as complexes from pectin with ASA 5 . The decrease in the toxicity of the studied acids in the composition of the complexes with pectin was shown.…”

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confidence: 99%

“…Moreover, for the complex of pectin with acetylsalicylic acid (P-ASA), the structure of which is given on the formula (I), the absence of an ulcerogenic effect on the gastric mucosa was revealed after a ten-day course with a P-ASA dose of 500 mg/kg. This dose corresponds to the equimolar therapeutic dose of ASA 50 mg/kg, which under similar conditions of administration caused the hyperemia of the gastric mucosa and the strengthening of the star-shaped vascular pattern 5,6 .…”

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2020

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The aim of this work is a comparison of antiinflammatory properties of the molecular pectin complex with 10% acetylsalicylic acid (P-ASA) and acetylsalicylic acid (ASA) in equimolar doses on the model of carrageenan-induced paw edema of rats. The study was carried out on a total of 28 adult male Sprague Dawley rats at 7 months of age. 30 min after injection of 1% aqueous solution of carrageenan to the plantar aponeurosis, studied drugs were orally administered once at the doses of 10, 20, 40 mg/kg ASA and 100, 200, 400 mg/kg P-ASA. The severity of edema, pain sensitivity, leukocyte count, its subpopulation ratio and IL-1β, IL-6, IL-8, TNFα level were determined. Normality, t-test and Mann-Whitney tests were used for statistical analyses. The ulcerogenic effect of P-ASA (dose 400 mg/kg) is significantly less than that of ACA (dose 40 mg/kg). The analgesic effect of P-ASA is comparable to ASA at equimolar doses. The anti-edema effect of ASA at the doses of 10 and 20 mg/kg is more pronounced than that of P-ASA at equimolar doses. P-ASA contributes to normalization of blood leukocyte profile. P-ASA may be recommended to using as anti-inflammatory agent with low ulcerogenic properties. INTRODUCTION: Studies in the development of anti-inflammatory drugs confirm their high relevance and take place in novel world literature 1, 2 .

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Section: Influence Of Preparations On Catalase Activity and Malondialsupporting

confidence: 92%

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confidence: 99%

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confidence: 99%

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2020

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“…In the IR spectra of free ligands, two typical profiles of bands for O–H stretching vibrations (υ-OH) were observed. In HL1 and HL2, the broad bands profile in the range 3,486–3,414 cm –1 and 3,078–2,546 cm –1 , respectively, correspond to υ-OH [26,27,28]. In the IR spectra of the complexes, these bands disappeared indicating the deprotonation of ligands and coordination with metal through the oxygen of the carboxyl group.…”

Section: Resultsmentioning

confidence: 99%

“…The C=O bands occur in the range of 1,750–1,600 cm – 1 [25,26]. In the free carboxylic acids, these absorption bands corresponding to the asymmetric stretching vibration of the carboxyl C=O group occur at 1,692 cm –1 (HL1) [26,27] and 1,678 cm –1 (HL2) [28]. In complexes 1 – 4 , weakening of C=O bond occurred upon complexation which causes the lowering of wavenumber corresponding to asymmetrical carboxylate stretching absorbances.…”

Section: Resultsmentioning

confidence: 99%

Novel Triphenylantimony(V) and Triphenylbismuth(V) Complexes with Benzoic Acid Derivatives: Structural Characterization, in Vitro Antileishmanial and Antibacterial Activities and Cytotoxicity against Macrophages

et al. 2014

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Two novel organoantimony(V) and two organobismuth(V) complexes of the type ML 2 were synthesized, with L = acetylsalicylic acid (HL1) or 3-acetoxybenzoic acid (HL2) and M = triphenylantimony(V) (M1) or triphenylbismuth(V) (M2 6010by elemental analysis, IR and NMR. Crystal structures of triphenylantimony(V) dicarboxylate complexes 1 and 2 were determined by single crystal X-ray diffraction. Structural analyses revealed that 1 and 2 adopt five-coordinated extremely distorted trigonal bipyramidal geometries, binding with three phenyl groups in the equatorial position and two deprotonated organic ligands (L) in the axial sites. The metal complexes, their metal salts and ligands were evaluated in vitro for their activities against Leishmania infantum and amazonensis promastigotes and Staphylococcus aureus and Pseudomonas aeruginosa bacteria. Both the metal complexes showed antileishmanial and antibacterial activities but the bismuth complexes were the most active. Intriguingly, complexation of organobismuth(V) salt reduced its activity against Leishmania, but increased it against bacteria. In vitro cytotoxic test of these complexes against murine macrophages showed that antimony(V) complexes were the least toxic. Considering the selectivity indexes, organoantimony(V) complexes emerge as the most promising antileishmanial agents and organobismuth(V) complex 3 as the best antibacterial agent.

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