volume 279, issue 47, P49064-49073 2004
DOI: 10.1074/jbc.m407715200
View full text
|
|
Share

Abstract: Mechanisms of mitochondrial superoxide formation remain poorly understood despite considerable medical interest in oxidative stress. Superoxide is produced from both Complexes I and III of the electron transport chain, and once in its anionic form it is too strongly charged to readily cross the inner mitochondrial membrane. Thus, superoxide production exhibits a distinct membrane sidedness or "topology." In the present work, using measurements of hydrogen peroxide (Amplex red) as well as superoxide (modified …

Expand abstract

Search citation statements

Order By: Relevance

Citation Types

19
537
3
13

Paper Sections

0
0
0
0
0

Publication Types

0
0
0
0

Relationship

0
0

Authors

Journals