Complex heterogeneous tissue constructs containing multiple cell types prepared by inkjet printing technology

Xu, Tao; Zhao, Weixin; Zhu, Jihong; Albanna, Mohammad Z.; Yoo, James J.; Atala, Anthony

doi:10.1016/j.biomaterials.2012.09.035

Cited by 520 publications

(345 citation statements)

References 28 publications

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“…Wake Forest, for example, will use a bioprinter to "print" cells into a hydrogel matrix, creating 3D organoids (4). The ATHENA team is doing something similar, layering cells onto 3D scaffolds.…”

Section: And Match Partsmentioning

confidence: 99%

Building benchtop human models

Dance¹

2015

Proc. Natl. Acad. Sci. U.S.A.

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Section: And Match Partsmentioning

confidence: 99%

Building benchtop human models

Dance¹

2015

Proc. Natl. Acad. Sci. U.S.A.

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“…This leads to the deposition of cells on the substrate in a pattern [54]. With inkjet-based bioprinting, droplets of living cells are created and released accurately onto a surface, based on a computergenerated template [55]. The beauty lies in its simplicity: a printer is used to print biological "ink" droplets onto biological "paper" [50].…”

Section: Integrins In Tissue Engineeringmentioning

confidence: 99%

Untitled

2017

JABB

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Chronic kidney disease (CKD) is the leading cause of death for individuals suffering from end-stage kidney failure. While kidney transplantation is the most viable solution to CKD, it has many challenges and limitations. This review evaluates kidney transplant rejection and the various transplantation methods that may be employed to treat CKD. Kidney rejection and long-term transplant survival is the main concern regarding transplantation attempts. Thus, scientist must screen and strategize appropriately to ensure kidney transplant survival. Tissue engineering techniques are explored as means to improve upon transplantation attempts. Research into ensuring adequate organ scaffold design has become crucial in the field of regenerative medicine. Furthermore, the role of integrins is discussed as a central component for future tissue engineering techniques, by taking the study of scaffold design to the molecular level. Finally, a glimpse into the current advancements of three-dimensional bioprinting highlights the future of tissue engineering and shows how the field of regenerative medicine is taking another step closer to developing "home-grown" kidneys. With the prospect of generating a fully lab-created, personalized kidney, CKD may one day be treated without encountering any of the limitations that have hindered previous attempts.

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“…The basement membrane with its nanoscale pores, ridges and fibres is the most crucial ECM structure providing tissue organisation and support [215]. Micro-and nanopatterning techniques including soft lithography, electrospinning, layer-by-layer microfluidic patterning, three-dimensional printing, reactive ion etching and ion milling have resulted in the fabrication of scaffolds with controlled porosity, geometry and rigidity and texture [216][217][218]. The production of specific surface topography scales (nano, micro), types (ridges, pit, pillar, grooves) and distributions (random, regular) has enabled researchers to study the influence of topographical signals on stem cell differentiation [214].…”

Section: Topographical Signals As Regulators Of Stem Cell Fatementioning

confidence: 99%

Pluripotent Stem Cells and Their Dynamic Niche

Reinwald¹,

Bratt²,

Haj³

2016

Pluripotent Stem Cells - From the Bench to the Clinic

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Cell-seeded implants are a regenerative medicine strategy that aims to replace injured tissue and restore tissue function. Pluripotent stem cells are promising cell candidates for the development of regenerative medicine therapies as they have the ability to selfrenew and commit towards numerous cell types. In vivo, stem cells reside in a dynamic niche, a stem cell-specific microenvironment that possesses chemical, biological and mechanical cues, which drive the stem cell fate and renewal. The connection between stem cells and their niche is a two-way relationship consisting of both cell-cell interaction and cell-extracellular matrix (ECM) interactions. An alternative regenerative medicine approach is the manipulation of the stem cell microenvironment. Hence, novel strategies have been developed including 3D biomaterials and bioreactor technologies providing topographical, chemical and mechanical cues to recreate the stem cell niche. Understanding the mechanisms controlling stem cell fate and the dynamic nature of the stem cell niche will enable researchers to replicate this stem cell-specific microenvironment, and therefore, harness and control the valuable attributes which stem cells possess. This chapter elucidates the importance of pluripotent stem cells and their dynamic niche in regenerative medicine. It further presents novel strategies to replicate chemical, topographical and mechanical stimuli which are essential for the regulation of stem cell fate and hence tissue regeneration.

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Complex heterogeneous tissue constructs containing multiple cell types prepared by inkjet printing technology

Cited by 520 publications

References 28 publications

Building benchtop human models

Building benchtop human models

Untitled

Pluripotent Stem Cells and Their Dynamic Niche

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