Complete spontaneous necrosis of hepatocellular carcinoma confirmed on resection: A case report

Saito, Ryusuke; Amano, Hodaka; Abe, Tomoyuki; Fujikuni, Nobuaki; Nakahara, Masaaki; Yonehara, Shuji; Teramen, Kazushi; Noriyuki, Toshio

doi:10.1016/j.ijscr.2016.03.027

Cited by 17 publications

(17 citation statements)

References 14 publications

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“…Histopathological findings of the resected hepatic specimens showed necrotic tissue; several cases also revealed inﬂammatory cell infiltration at the tissue periphery[12,21]. Remnant tumor, persistence of tumor cell, was confirmed by the imaging modalities in 2 patients after the spontaneous regression.…”

Section: Prognosismentioning

confidence: 99%

Spontaneous regression of hepatocellular carcinoma: A mini-review

Sakamaki

Kamimura

Abe

et al. 2017

WJG

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Spontaneous tumor regression is an extremely rare phenomenon in the oncology field. However, there are several case reports resulted in the regression of hepatocellular carcinoma (HCC) and the accumulation of clinical information and analyses of the mechanism can contribute to the development of a novel therapy. For this purpose, we have carefully reviewed 23 cases of spontaneously regressed HCC published in recent 5 years and our case. The information regarding the tumor size, tumor marker, treatments, etc., have been summarized. The mechanism of spontaneous regression has been discussed to date and presumed to be due to many factors, including hypoxia and immunological reactions. In this careful review of the 24 cases based on the clinical information, hypoxia, systemic inflammation, and both upon spontaneous regression were seen in 3, 8, and 4 cases, respectively among the 15 cases for which the information regarding the proposed mechanisms are available. Recent development of immunotherapeutic approaches in oncology shows promising results, therefore, accumulation of additional cases and analysis of mechanisms underlying the spontaneous regression of HCC are essential and could lead to the development of a new generation of immunotherapies including antibodies directed against immune reactions.

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Section: Prognosismentioning

confidence: 99%

Spontaneous regression of hepatocellular carcinoma: A mini-review

Sakamaki

Kamimura

Abe

et al. 2017

WJG

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“…Spontaneous regression may occur in approximately 1/100,000 patients with malignant tumor including HCC. Only 12 pathologically proven cases of HCC regression (including our case) have been reported in the literature [10]. Hypothesis 3: an arterial trauma may cause ischemia.…”

Section: Discussionmentioning

confidence: 99%

Complete necrosis of hepatocellular carcinoma after preoperative portal vein embolization: a case report

et al. 2017

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BackgroundHepatocellular carcinoma has a poor prognosis; few patients can undergo surgical curative treatment according to Barcelona Clinic Liver Cancer guidelines. Progress in surgical techniques has led to operations for more patients outside these guidelines. Our case shows a patient with intermediate stage hepatocellular carcinoma presenting a good outcome after curative treatment.Case presentationWe report the case of an 80-year-old Moroccan man, who was positive for hepatitis c virus, presenting an intermediate stage hepatocellular carcinoma (three lesions between 20 and 60 mm). He presented a complete tumor necrosis after portal vein embolization and achieved 24-month disease-free survival after surgery.ConclusionsPerioperative care in liver surgery and multidisciplinary discussion can help to extend indications for liver resection for hepatocellular carcinoma outside European Association for the Study of the Liver/American Association for the Study of Liver Diseases recommendations and offer a curative approach to selected patients with intermediate and advanced stage hepatocellular carcinoma.

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“…However, in recent reports, the incidence of spontaneous regression in lung and liver cancers was also considered to be not rare. Based on the current literature review, many factors resulting in spontaneous regression of HCC have been proposed ( Table 1 ) [ [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] ]. Two common mechanisms of spontaneous HCC regression were identified: tumor hypoxia and systemic inflammatory and immunological activation [ 31 , 37 ].…”

Section: Discussionmentioning

confidence: 99%