Complete Nucleotide Sequence of a 43-Kilobase Genomic Island Associated with the Multidrug Resistance Region of<i>Salmonella enterica</i>Serovar Typhimurium DT104 and Its Identification in Phage Type DT120 and Serovar Agona

Boyd, David A.; Peters, Geoffrey A.; Cloeckaert, Axel; Sidi-Boumedine, Karim; Chaslus-Dancla, Élisabeth; Imberechts, Hein; Mulvey, Michael R.

doi:10.1128/jb.183.19.5725-5732.2001

Cited by 368 publications

(483 citation statements)

References 37 publications

Supporting

Mentioning

462

Contrasting

Unclassified

Order By: Relevance

“…They may be part of mobile elements such as transposons, plasmids, and chromosomal genomic islands. Integrons usually carry one or more antibiotic resistance gene cassettes and can sometimes be complex such as the class 1 integron found in SGI1 [21]. In such a case, it looks more like an antibiotic resistance gene cluster and to date SGI1 variants have been identified carrying up to six antibiotic resistance genes, conferring a multiple-antibiotic resistance profile to antibiotic families of clinical importance such as β-lactams, aminoglycosides, phenicols, sulfonamides, tetracyclines, and trimethoprim [21,22].…”

Section: Source Of Emergence: Microbial Genome Evolutionmentioning

confidence: 99%

“…Integrons usually carry one or more antibiotic resistance gene cassettes and can sometimes be complex such as the class 1 integron found in SGI1 [21]. In such a case, it looks more like an antibiotic resistance gene cluster and to date SGI1 variants have been identified carrying up to six antibiotic resistance genes, conferring a multiple-antibiotic resistance profile to antibiotic families of clinical importance such as β-lactams, aminoglycosides, phenicols, sulfonamides, tetracyclines, and trimethoprim [21,22]. In addition, the structures carrying these various antibiotic resistance genes may undergo recombinational, gene replacement and gene capture events, which can lead to a wide variety of antibiotic resistance gene clusters [22,43,44].…”

Section: Source Of Emergence: Microbial Genome Evolutionmentioning

confidence: 99%

“…The ApCmFfStSpSuTc multiple-antibiotic resistance profile of S. Typhimurium DT104 is conferred by an antibiotic resistance gene cluster carried by a chromosomal genomic island called Salmonella genomic island 1 (SGI1) [20,21]. The 43 kb-size SGI1 is located between the thdF and int2 genes of the chromosome of S. Typhimurium DT104 and is flanked by an imperfect 18-bp direct repeat (Fig.…”

Section: The Salmonella Genomic Island 1 (Sgi1)mentioning

confidence: 99%

See 2 more Smart Citations

Emergence of Salmonella epidemics: The problems related to Salmonella enterica serotyp Enteritidis and multiple antibiotic resistance in other major serotypes

Cloeckaert²,

2005

Self Cite

View full text Add to dashboard Cite

-Two major changes in the epidemiology of salmonellosis occurred in the second half of the 20th century: the emergence of food-borne human infections caused by S. Enteritidis and by multiple-antibiotic resistant strains of Salmonella. This review updates information on the S. Enteritidis pandemic and focuses on the emergence of Salmonella, carrying the SGI1 antibiotic resistance gene cluster, resistant to extended-spectrum cephalosporins, or resistant to fluoroquinolones. The factors responsible for the emergence of these Salmonella strains could be either of human origin or related to bacterial genome evolution. However, our increasing understanding of the molecular fluidity of the genome shows that any attempt to counteract bacteria results in further bacterial evolution or adaptation of other bacteria to take place in the new free ecological niche. In these conditions, we can ask who is faster: humans who want to eliminate bacterial pathogens or bacteria that continuously evolve to gain new niches.

show abstract

Section: Source Of Emergence: Microbial Genome Evolutionmentioning

confidence: 99%

Section: Source Of Emergence: Microbial Genome Evolutionmentioning

confidence: 99%

Section: The Salmonella Genomic Island 1 (Sgi1)mentioning

confidence: 99%

See 1 more Smart Citation

Emergence of Salmonella epidemics: The problems related to Salmonella enterica serotyp Enteritidis and multiple antibiotic resistance in other major serotypes

Cloeckaert²,

2005

Self Cite

View full text Add to dashboard Cite

show abstract

“…Several different SGI1 variants exist, many of which mediate resistance to penicillin, streptomycin, tetracycline, chloramphenicol/ florfenicol and sulfonamides. SGI1 was initially detected in the chromosomal DNA of S. Typhimurium DT104, later it was also detected in the chromosomal DNA of other S. Typhimurium phage types and S. enterica serovars [33,34]. The location of resistance genes on the chromosome rules out the possibility of losing the resistance property under conditions of low selective pressure.…”

mentioning

confidence: 99%

A quantitative approach to analyse linkages between antimicrobial resistance properties inSalmonellaTyphimurium isolates

et al. 2011

View full text Add to dashboard Cite

SUMMARYThis study used statistical methods to investigate linkages in phenotypic resistance profiles in a population sample of 321 Salmonella Typhimurium isolates from sporadic salmonellosis cases in Lower Saxony, Germany, collected during 2008-2010. A resistance index was applied to calculate the conditional probability of resistance to one antimicrobial agent given the resistance to one or more other antimicrobial agent(s). A susceptibility index was defined analogously. A contingency plot, which visualizes the association between resistances to two antimicrobial agents, facilitated the interpretation. Linkages between minimum inhibitory concentrations (MIC) were analysed using Spearman's rank correlation coefficient and jittered scatter plots. Applying these methods provided a compact description of multi-resistance and linkages between resistance properties in large datasets. Moreover, this approach will improve monitoring of antimicrobial resistance dynamics of bacteria in human or animal populations by identifying linked resistance to antimicrobial agents (cross-or co-resistance) with a non-molecular method.

show abstract

“…That strain has a Salmonella genomic island 1 (SG1) carrying different resistance genes which are integrated in an integron of class 1. [9] Class 1 integrons are important in the dissemination of antibiotic resistance genes in Gram-negative bacteria, including E. coli and Salmonella.…”

Section: Intrinsic or Natural Resistancementioning

confidence: 99%

Antibiotic use and resistance in animals: Belgian initiatives

Daeseleire¹,

Graef

Rasschaert³

et al. 2016

Drug Testing and Analysis

View full text Add to dashboard Cite

The widespread use of antibiotics in animals is causing concerns about the growing risk for development and the spread of antibiotic-resistant bacteria. Antibiotic consumption is higher in animals than in humans as reported in a joint publication of EFSA (European Food Safety Agency), ECDC (European Centre for Disease Prevention and Control), and EMA (European Medicines Agency) using data from 2011 and 2012. Both in humans and animals, positive associations between the consumption of antibiotics and resistant bacteria are observed. Responsible use of antibiotics in humans and animals should therefore be promoted. In this paper some general aspects of antibiotic resistance such as microbiological versus clinical resistance, intrinsic versus acquired resistance, resistance mechanisms, and transfer of resistance are briefly introduced. In 2012, the Belgian Center of Expertise on Antimicrobial Consumption and Resistance in Animals (AMCRA) was founded. Its mission is to collect and analyze all data related to antibiotic use and resistance in animals in Belgium and to communicate these findings in a neutral and objective manner. One of AMCRA's 10 objectives is a 50% reduction in antibiotic consumption in veterinary medicine in Belgium by 2020. The aim of this paper is to report on the achievements of this national project. The Institute for Agricultural and Fisheries Research (ILVO, Merelbeke-Melle), in collaboration with Ghent University, is currently working on three nationally funded projects on antibiotic resistance in animal husbandry. In the first project, an in vitro model is used to study the influence of low antibiotic concentrations due to carry-over after production and usage of medicated feed on the development of resistance in the pig gut. Part of that project is to develop a quantitative risk assessment model. A second project focuses on tracking excreted antibiotics used in pig rearing and their influence on the development of antibiotic resistance in pig manure and the environment. In the last project, the relation between the use of biocides in animal husbandry and antibiotic resistance development are being studied. Copyright

show abstract

Complete Nucleotide Sequence of a 43-Kilobase Genomic Island Associated with the Multidrug Resistance Region ofSalmonella entericaSerovar Typhimurium DT104 and Its Identification in Phage Type DT120 and Serovar Agona

Cited by 368 publications

References 37 publications

Emergence of Salmonella epidemics: The problems related to Salmonella enterica serotyp Enteritidis and multiple antibiotic resistance in other major serotypes

Emergence of Salmonella epidemics: The problems related to Salmonella enterica serotyp Enteritidis and multiple antibiotic resistance in other major serotypes

A quantitative approach to analyse linkages between antimicrobial resistance properties inSalmonellaTyphimurium isolates

Antibiotic use and resistance in animals: Belgian initiatives

Contact Info

Product

Resources

About