Complete Mitochondrial Sequences for Haplogroups M23 and M46: Insights into the Asian Ancestry of the Malagasy Population

Dubut, Vincent; Cartault, François; Payet, Christine; Thionville, Marie-Dominique; Murail, Pascal

doi:10.3378/027.081.0407

Cited by 10 publications

(8 citation statements)

References 29 publications

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“…Subsequent research revealed the complex nature of settlement on this island, with the inclusion of at least three putative parental populations of African, Indonesian and Indian origin [4], [5], [6], [7]. A similar result was obtained for the Comoro Archipelago [8], [9].…”

Section: Introductionsupporting

confidence: 56%

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Multiple Ethnic Origins of Mitochondrial DNA Lineages for the Population of Mauritius

et al. 2014

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This article reports on the first genetic assessment of the contemporary Mauritian population. Small island nodes such as Mauritius played a critical role in historic globalization processes and revealing high-resolution details of labour sourcing is crucial in order to better understand early-modern diaspora events. Mauritius is a particularly interesting case given detailed historic accounts attesting to European (Dutch, French and British), African and Asian points of origin. Ninety-seven samples were analysed for mitochondrial DNA to begin unravelling the complex dynamics of the island's modern population. In corroboration with general demographic information, the majority of maternal lineages were derived from South Asia (58.76%), with Malagasy (16.60%), East/Southeast Asian (11.34%) and Sub-Saharan African (10.21%) also making significant contributions. This study pinpoints specific regional origins for the South Asian genetic contribution, showing a greater influence on the contemporary population from northern and southeast India. Moreover, the analysis of lineages related to the slave trade demonstrated that Madagascar and East Asia were the main centres of origin, with less influence from West Africa.

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Section: Introductionsupporting

confidence: 56%

“…The analysis of complete genome sequences from Madagascar revealed an autochthonous linage named M23 [4], [25]. Our complete mtDNA study also discovered an unidentified M type that only shares the common M mutations.…”

Section: Discussionmentioning

confidence: 59%

Multiple Ethnic Origins of Mitochondrial DNA Lineages for the Population of Mauritius

et al. 2014

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“…The isolate Ar2461 (Additional file 2: Table S1) has the diagnostic mutations of the Andaman branch M31a1 in the regulatory (249d, 16311) and coding (3975, 3999) regions. On the other hand, the complete mtDNA sequence of Ar1076 (Additional file 1: Figure S1) belongs to the M32c Andamanese branch, matching it with another complete sequence from Madagascar [72]. It must be stressed that this branch has been steadily found in all mtDNA reports on Madagascar [73–75].…”

Section: Resultsmentioning

confidence: 90%

Carriers of human mitochondrial DNA macrohaplogroup M colonized India from southeastern Asia

et al. 2016

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BackgroundFrom a mtDNA dominant perspective, the exit from Africa of modern humans to colonize Eurasia occurred once, around 60 kya, following a southern coastal route across Arabia and India to reach Australia short after. These pioneers carried with them the currently dominant Eurasian lineages M and N. Based also on mtDNA phylogenetic and phylogeographic grounds, some authors have proposed the coeval existence of a northern route across the Levant that brought mtDNA macrohaplogroup N to Australia. To contrast both hypothesis, here we reanalyzed the phylogeography and respective ages of mtDNA haplogroups belonging to macrohaplogroup M in different regions of Eurasia and Australasia.ResultsThe macrohaplogroup M has a historical implantation in West Eurasia, including the Arabian Peninsula. Founder ages of M lineages in India are significantly younger than those in East Asia, Southeast Asia and Near Oceania. Moreover, there is a significant positive correlation between the age of the M haplogroups and its longitudinal geographical distribution. These results point to a colonization of the Indian subcontinent by modern humans carrying M lineages from the east instead the west side.ConclusionsThe existence of a northern route, previously proposed for the mtDNA macrohaplogroup N, is confirmed here for the macrohaplogroup M. Both mtDNA macrolineages seem to have differentiated in South East Asia from ancestral L3 lineages. Taking this genetic evidence and those reported by other disciplines we have constructed a new and more conciliatory model to explain the history of modern humans out of Africa.Electronic supplementary materialThe online version of this article (doi:10.1186/s12862-016-0816-8) contains supplementary material, which is available to authorized users.

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“…East Asian ancestry was assigned to haplogroups A12, B (excluding B2), C (excluding C1 and C4c), D (excluding D1 and D2a), E, F, M (excluding M1), N9, and Z. Although the origins of haplogroup M23 are still unclear [40,41] [43][44][45][46]. The Kimura 2-parameter model, which differentiates mutation rates of transitions from transversions, was used for Fst calculations [47], and Bonferroni corrections (simple and sequential) were applied before determining significant comparisons [48].…”

Section: Data Analysesmentioning

confidence: 99%

The mitochondrial landscape of African Americans: An examination of more than 2500 control region haplotypes from 22 U.S. locations

Scheible¹,

Just²,

Sturk-Andreaggi³

et al. 2016

Forensic Science International: Genetics

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The mitochondrial DNA (mtDNA) control region (16024-576) was Sanger-sequenced for a total of 2563 self-identified African Americans, using automated processing techniques and data review standards exceeding guidelines for forensic applications. Genetic diversity ranged from 0.9952 to 0.9998 in 22 population samples from 20 different states. Haplogroups of African ancestry, found in 82.48% of individuals overall, were most concentrated in the Southeast U.S. and decreased to the north and west. West African and West Central African haplotypes were well-represented in the population samples, especially in the southern U.S. states, while East African haplogroups were observed in low-frequency clusters in a handful of locations across the country. East Asian, Native American, and West Eurasian admixture was present in 3.16%, 2.93%, and 11.43% of samples, respectively. While some geographic substructure was detected across the population samples as clines in admixture frequencies, 20 of the 22 population samples were found to be statistically indistinguishable by pairwise comparisons and AMOVA calculations. Datasets from Hawaii and Idaho, however, were clear outliers. Overall, these more than 2500 control region sequences represent the most comprehensive regional sampling of African American mtDNA diversity to date, and are suitable for use in a forensic mtDNA database. The population data are made available via EMPOP (www.empop.org) and GenBank.

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Complete Mitochondrial Sequences for Haplogroups M23 and M46: Insights into the Asian Ancestry of the Malagasy Population

Cited by 10 publications

References 29 publications

Multiple Ethnic Origins of Mitochondrial DNA Lineages for the Population of Mauritius

Multiple Ethnic Origins of Mitochondrial DNA Lineages for the Population of Mauritius

Carriers of human mitochondrial DNA macrohaplogroup M colonized India from southeastern Asia

The mitochondrial landscape of African Americans: An examination of more than 2500 control region haplotypes from 22 U.S. locations

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