volume 4, issue 12, P966-977 2012
DOI: 10.18632/aging.100526
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Bernhard Johannes Haubner, Martyna Adamowicz-Brice, Sanjay Khadayate, Viktoria Tiefenthaler, Bernhard Metzler, Tim Aitman, Josef M. Penninger

Abstract: Cardiac remodeling and subsequent heart failure remain critical issues after myocardial infarction despite improved treatment and reperfusion strategies. Recently, complete cardiac regeneration has been demonstrated in fish and newborn mice following resection of the cardiac apex. However, it remained entirely unclear whether the mammalian heart can also completely regenerate following a complex cardiac ischemic injury. We established a protocol to induce a severe heart attack in one-day-old mice using left an…

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