2012
DOI: 10.18632/aging.100526
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Abstract: Cardiac remodeling and subsequent heart failure remain critical issues after myocardial infarction despite improved treatment and reperfusion strategies. Recently, complete cardiac regeneration has been demonstrated in fish and newborn mice following resection of the cardiac apex. However, it remained entirely unclear whether the mammalian heart can also completely regenerate following a complex cardiac ischemic injury. We established a protocol to induce a severe heart attack in one-day-old mice using left an… Show more

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Cited by 186 publications
(212 citation statements)
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References 30 publications
(212 reference statements)
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“…Consistent with previous reports, we demonstrate that neonatal mice have a remarkable ability to recover cardiac function, whereas adult mice have a significantly limited capacity (10)(11)(12)(13)(14). The precise macrophage characterization and lineage tracing studies performed herein show that the injured neonatal heart contains an embryonic-derived lineage of cardiac macrophages that promote cardiomyocyte proliferation and coronary angiogenesis, but produce minimal inflammation.…”
Section: Inhibition Of Monocyte Recruitment Preserves Embryonic-derivedsupporting
confidence: 91%
“…Consistent with previous studies reporting age-related reduction in the ability to regenerate myocardium after apical resection or coronary artery ligation (10,11,13), postnatal day 1 (P1) mice demonstrated minimal mortality after either one or three DT injections. In contrast, P14 and adult mice displayed significantly higher dose-dependent mortality.…”
supporting
confidence: 86%
“…Comparatively, neonatal hearts are capable of regenerating following cardiac injury [7][8][9], which is dependent on the proliferative competency of neonatal cardiomyocytes. The loss of this cardioregenerative capacity during early postnatal life coincides with dramatic changes in the transcriptional and epigenetic landscape [10][11][12].…”
Section: Introductionmentioning
confidence: 99%
“…Integrin also plays an essential role in the assembly of ibrillin-1 into a structured network [78,89]. Fibulins are tightly connected with basement membranes, elastic ibres and other components of extracellular matrix and participate in formation of elastic ibres [83,86].…”
Section: Lim Et Al Related That Their Results On Poly(l-lactic Acid)mentioning
confidence: 99%
“…Thus, evidence has accumulated over the past 20 years to demonstrate that there is some amount of cardiac turnover, both in healthy and injured tissues [63,77], and this has prompted eforts to devise cardiomyocyte replacement therapies by the promotion of endogenous regenerative process [60,62]. Evidence from rodent [86], axolotls, newts, zebraish [77] and human studies challenges the view of the heart as a terminally diferentiated organ and unable to regenerate [67]. The ability of ECM biomaterials to stimulate robust endogenous cardiac regeneration without adding exogenous cells would avoid these issues, today more and more studies show that this utopia is not more the 'holy grail' of heart regeneration.…”
Section: Efect Of Acellular Scafold On Ventricular Function and Cardimentioning
confidence: 99%