Complete 2D NMR assignment and antifungal activity of ishwarane isolated from &lt;i&gt;Hortonia&lt;/i&gt;, a genus endemic to Sri Lanka

Ratnayake, Rukmal; Jayasinghe, Susanthi; Bm, Bandara; Andersen, Raymond J.; Karunaratne, Veranja

doi:10.4038/jnsfsr.v36i1.139

Cited by 7 publications

(5 citation statements)

References 12 publications

(8 reference statements)

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“…Thus, in order to complete the structure, the remaining two methyl groups (attached to quaternary carbons) were placed at C-1 and C-5. The resulting structure which fitted the data was concluded to be 1, 5, 12-trimethyltetracyclic [6, 3, 0, 0, 0 3, 4, 8 ] dodecane (1) (Ratnayake et al, 2008b).…”

Section: Resultsmentioning

confidence: 99%

“…We have previously reported the isolation of several biologically active and unique natural products from the three species of genus Hortonia ( Ratnayake et al, 2001;Ratnayake et al, 2008a;Ratnayake et al, 2008b;Ratnayake et al, 2008c;Carr et al, 2012). As part of our continuing research to find biologically active compounds from this plant, we isolated one tetracyclic sesquiterpene.…”

Section: Introductionmentioning

confidence: 99%

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A novel Tetracyclic Sesquiterpene from the Genus <em>Hortonia</em>

Ratnayake¹,

Wickramaratne²

2017

Ceylon J. Sci.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A novel Tetracyclic Sesquiterpene from the Genus <em>Hortonia</em>

Ratnayake¹,

Wickramaratne²

2017

Ceylon J. Sci.

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“…A study was undertaken to investigate the phytochemistry of all three species, based on the near identity of TLC patterns and the mosquitolarvicidal activity of the leaf extracts of the three species. Previously, the authors have reported the isolation of several new butenolides with mosquitolarvicidal activity from the leaves of all three species (Ratnayake et al, 2001(Ratnayake et al, , 2008a(Ratnayake et al, , 2008b. It was concluded from these studies that the three species were phytochemically very similar.…”

Section: Introductionmentioning

confidence: 94%

Evaluation of species limits of Hortonia by DNA barcoding

Rajapakse

Iddamalgoda

Ratnayake

et al. 2012

J. Natn. Sci. Foundation Sri Lanka

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A study was carried out to determine the species limits of the endemic genus Hortonia by DNA barcoding with a view to establishing conclusive molecular evidence regarding the speciation of Hortonia in Sri Lanka. Total DNA was extracted from all three species and the purity of the extracted DNA was confirmed. Internal transcribed spacer (ITS) region and the trnH-psbA region were first amplified by the polymerase chain reaction (PCR) with specific primers and ligated to a pBlueScript vector followed by plasmid purification. The purified plasmids containing the DNA of interest were subjected to sequencing. Sequence homology of ITS and trnH-psbA from all three species were compared using MacVector software. Between H. ovalifolia and H. floribunda, the ITS region showed a 2.37 % sequence divergence and the trnH-psbA region showed a 1.5 % sequence divergence. Between H. ovalifolia and H. angustifolia, the ITS region and trnH-psbA region showed a 3.36 % and 1.89 % sequence divergences, respectively. The percentage sequence divergence between ITS and trnH-psbA regions of H. floribunda and H. angustifolia were 3.36 % and 2.65 %, respectively. The high sequence divergence values clearly indicate that the genus Hortonia has three different species. Considering the percentage sequence divergence values, H. ovalifolia and H. floribunda are more closely related to each other than to H. angustifolia.

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“…Ishwarane belonging to sesquiterpenoid class was first isolated from the plants Aristolochia indica and Cembopentalum penduliflorum. It has been isolated from the essential oils of Bixa orellana, Corallocarpus epigaeus and Piper fulvescens [12]. Ishwarane exhibited antifungal activity against C. albicans and C. cladosporioides [12,13].…”

Section: Chemical Compositionmentioning

confidence: 99%

Volatile Compounds and Biological Activities of Essential Oil of Globba Pendula Roxb. Collected at an Giang Province

Phương

Thuy

Thảo

et al. 2020

JST

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Twenty-five compounds were identified from the essential oil of Globba pendula Roxb. by gas chromatography–mass spectrometry (GC-MS) with Selinene<d-> (22.09%) as the main component, followed by Ishwarane (6.52%). The essential oil was found to possess moderate NO inhibitory effect with IC50 of 41.68 ±4.51 µg/ml, significant cytotoxic activity against MCF7 and Hep3B cell lines with IC50 of 28.15±1.08 and 35.24±0.06 (µg/ml), respectively. This is the first report on volatile compounds and biological activities of essential oil of Globba pendula Roxb. collected at An Giang province, Vietnam.

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Complete 2D NMR assignment and antifungal activity of ishwarane isolated from <i>Hortonia</i>, a genus endemic to Sri Lanka

Cited by 7 publications

References 12 publications

A novel Tetracyclic Sesquiterpene from the Genus <em>Hortonia</em>

A novel Tetracyclic Sesquiterpene from the Genus <em>Hortonia</em>

Evaluation of species limits of Hortonia by DNA barcoding

Volatile Compounds and Biological Activities of Essential Oil of Globba Pendula Roxb. Collected at an Giang Province

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