volume 66, issue 8, P4794-4802 1992
DOI: 10.1128/jvi.66.8.4794-4802.1992
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Abstract: Murine cell lines expressing human CD4 are resistant to the fusogenic effect of the human immunodeficiency virus (HIV) envelope. Consequently, they cannot be infected by HIV or form syncytia with HIV envelopeexpressing cells. Murine cells could either lack human-specific cofactors necessary for the CD4/envelopemediated membrane fusion or express inhibitors of this process. To address this question, we have tested the ability of heterokaryons made from CD4-expressing murine cells and human cells to undergo HIV …

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