Complementary and alternative therapies for stable angina pectoris of coronary heart disease

Abstract

Background: Stable angina pectoris in patients with coronary heart disease is a clinical syndrome of rapid transient ischemia and hypoxia of myocardium due to the increase of myocardial load on the basis of fixed severe coronary artery stenosis. In recent years, the incidence rate of this disease has been rising steadily, which seriously threatens human life and health. When the disease occurs, its complementary and alternative therapy can relieve chest pain, improve cardiac function, and reduce adverse events. However, in retrospect of all the studies, we lack systematic analysis of the efficacy and safety of various complementary and alternative therapies. The curative effects were ranked. On the basis of these findings, we conducted a study of complementary and alternative therapy in patients with coronary heart disease, and proposed a network meta-analysis (NMA) protocol to explore the efficacy of different complementary and alternative therapies.Methods: We will comprehensively search the Chinese and English databases from the creation date to January 15, 2022. The randomized controlled trials of the supplementary and alternative treatment of stable angina pediatrics in patients with coronary heart disease and the relevant literature of the ongoing trials will be published. The 2 researchers will conduct literature screening and data extraction independently, using Cochrane system evaluator manual 5 3. The recommended bias risk assessment tool was used to evaluate the quality of the included study, Q-test was used and combined with heterogeneity analysis, and the analysis sensitivity was observed. The Review Manager 5.4 software provided by Cochrane Collaboration Network is used to statistically analyze the included literature, and the obtained results are made into forest map and funnel map for data analysis and processing. It is suggested that the evaluation will be used to formulate and evaluate the level, so as to classify the quality of NMA evidence.Results: Through analysis, we will get the efficacy and safety ranking of different complementary and alternative therapies in the treatment of stable angina pediatrics in patients with coronary heart disease, so as to provide further reference for the selection of clinical treatment methods. Conclusion:The complementary and alternative treatment of stable angina peptis in patients with coronary heart disease has a positive effect on improving its symptoms. This study can provide evidence support for clinicians and patients.INPLASY registration number: INPLASY202210066.

Effectiveness of Shuxuening injection in coronary heart disease: a systematic review and meta-analysis

“…Among them, 1,027 were duplicates, and 657 were excluded after reading the title or abstract. Finally, 51 trials were reviewed at the full-text level for further evaluation, of which 12 were excluded (Reasons of excluding studies were provided in Supplementary Table S5), and the remaining 39 studies (Cui et al, 2008;Gao et al, 2009;Wang and Zhang, 2009;Chai, 2010;SUn, 2010;Zhong, 2010;Zhou, 2010;Zhuang and Wu, 2010;Gao and Feng, 2011;Sui, 2011;Zhang and Yu, 2011;Zhao and Liu, 2011;Ma and Xi, 2012;Meng et al, 2012;Xu, 2012;Zhang, 2012;Liu and Zhang, 2013;Yuan, 2013;Dai, 2014;He et al, 2014;Ren and Wang, 2014;Zhu, 2014;Li, 2015;Liu and Cheng, 2015;Wang, 2015;Chen et al, 2016;Wu, 2016;Zhang, 2016;Zhou, 2017;Liu, 2018;Zhang et al, 2018;Sun et al, 2019;Cai, 2021;He et al, 2022;Zhang, 2022) were included in the final review (Figure 1).…”

“…A total of 19 out of the included 39 studies reported adverse reactions. Of these, no adverse reactions were observed in eight studies (Danesh et al, 1998;Wang and Zhang, 2009;Zhou, 2010;Zhang and Yu, 2011;Zhao and Liu, 2011;Xu, 2012;Ren and Wang, 2014;He et al, 2022). Two studies (SUn, 2010;He et al, 2014) reported no adverse reactions in the experimental group, but adverse reactions such as facial flushing and the slightly increased of alanine aminotransferase (ALT) were observed in the control group.…”

Efficacy and safety of Danlou tablets in traditional Chinese medicine for coronary heart disease: a systematic review and meta-analysis

“…Among the 17 RCTs, 10 (17-26) were randomly assigned by the random number table method and rated as low risk, while the rest (27)(28)(29)(30)(31)(32)(33) did not describe the method of random sequence generation and were rated as unclear; only one (20) used double-blind and placebo controls, and the use of blindness and allocation hiding was rated as low risk, while the rest (17)(18)(19)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33) did not mention the use of blindness and allocation hiding and were rated as unclear; none of the studies (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33) reported outcome indicators with incomplete information, and none of them had a selective reporting; thus, their risk rating was evaluated as low. For other biases, all (17)(18)(19)(20)(21)…”

The Causal Relationship between Angina Pectoris and Gout Based on Two Sample Mendelian Randomization

“…According to pathological anatomy and the observed pathophysiological changes, angina pectoris has a clinical phenotype of coronary heart disease, which is related to the atherosclerosis of coronary arteries causing luminal narrowing or occlusion. Moreover, an increase in myocardial load results in temporary ischaemia and myocardial hypoxia, which leads to the patient developing clinical manifestations such as chest tightness, chest pain, and shortness of breath [ 5 , 6 ].…”