Complementary and alternative medicine modalities used to treat adverse effects of anti-cancer treatment among children and young adults: a systematic review and meta-analysis of randomized controlled trials

Mora, Dana C.; Overvåg, Grete; Jong, Miek C.; Kristoffersen, Agnete Egilsdatter; Stavleu, Debbie C; Liu, Jianping

doi:10.1186/s12906-022-03537-w

Cited by 15 publications

(11 citation statements)

References 55 publications

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“…The goal of applying supportive care is to improve the quality of life of children with cancer and their families by treating the adverse effects caused by cancer treatment. Modalities such as acupuncture [ 15 , 16 , 57 – 59 ], massage [ 12 ], aromatherapy [ 60 ], healing [ 61 ], music [ 62 ], play therapy [ 63 ], and psychodrama [ 64 ] have beneficial outcomes in children [ 17 , 65 ]. In general, we found that supportive care modalities are used to provide comfort and control to the patients and parents; this is in line with other studies [ 66 – 68 ].…”

Section: Discussionmentioning

confidence: 99%

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Supportive care for cancer-related symptoms in pediatric oncology: a qualitative study among healthcare providers

Mora

Jong

Quandt

et al. 2023

BMC Complement Med Ther

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Background The aim of this study is to gain insight into the clinical experiences and perceptions that pediatric oncology experts, conventional healthcare providers, and complementary and alternative medicine (CAM) providers in Norway, Canada, Germany, the Netherlands, and the United States have with the use of supportive care, including CAM among children and adolescents with cancer. Methods A qualitative study was conducted using semi-structured in-depth interviews (n = 22) with healthcare providers with clinical experience working with CAM and/or other supportive care among children and adolescents with cancer from five different countries. Participants were recruited through professional associations and personal networks. Systematic content analysis was used to delineate the main themes. The analysis resulted in three themes and six subthemes. Results Most participants had over 10 years of professional practice. They mostly treated children and adolescents with leukemia who suffered from adverse effects of cancer treatment, such as nausea and poor appetite. Their priorities were to identify the parents' treatment goals and help the children with their daily complaints. Some modalities frequently used were acupuncture, massage, music, and play therapy. Parents received information about supplements and diets in line with their treatment philosophies. They received education from the providers to mitigate symptoms and improve the well-being of the child. Conclusions Clinical experiences of pediatric oncology experts, conventional health care providers, and CAM providers give an understanding of how supportive care modalities, including CAM, are perceived in the field and how they can be implemented as adaptational tools to manage adverse effects and to improve the quality of life of children diagnosed with cancer and the families.

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Section: Discussionmentioning

confidence: 99%

“…Studies have reported that massage therapy [ 12 ] and acupuncture [ 15 , 16 ] among others provide benefits to children during cancer treatment. A systematic review of randomized controlled trials (RCT) from 2022 [ 17 ] showed that CAM, including acupuncture and hypnosis, reduces chemotherapy-induced nausea and vomiting.…”

Section: Introductionmentioning

confidence: 99%

Supportive care for cancer-related symptoms in pediatric oncology: a qualitative study among healthcare providers

Mora

Jong

Quandt

et al. 2023

BMC Complement Med Ther

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“…23,24 Our research teams conducted a systematic review of RCTs in 2021. 25 The systematic review aimed to review the research literature to identify any CAM modalities used to treat adverse effects of conventional cancer treatment among children and young adults. The meta-analysis showed that CAM (including acupuncture and hypnosis) was effective in reducing chemotherapy induced nausea and vomiting (CINV) in children and young adults.…”

Section: Introductionmentioning

confidence: 99%

“…The analysis demonstrated that only 29% of the studies included reported data on safety. 25 Many studies about CAM modalities (ie, acupressure, healing touch, massage, music therapy, reiki) investigate effectiveness, but they do not address or report safety events among the reviewed studies. [26][27][28] In this review we want to investigate the safety of CAM modalities used to treat adverse effects of conventional cancer treatment in children and young adults.…”

Section: Introductionmentioning

confidence: 99%

Safety of Complementary and Alternative Medicine (CAM) treatment among children and young adults who suffer from adverse effects of conventional cancer treatment: A systematic review

et al. 2022

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Background: Complementary and Alternative Medicine (CAM) is widely used around the world to treat adverse effects derived from cancer treatment among children and young adults. Parents often seek CAM to restore and maintain the child’s physical and emotional condition during and after cancer treatment. Objectives: The objectives of this review were (i) to identify literature that investigates CAM use for treating adverse effects of conventional cancer treatment, (ii) to investigate the safety of the included CAM modalities, and (iii) to evaluate the quality of included studies. Methods: Five scientific research databases were used to identify observational, quasi-experimental, and qualitative studies from January 1990 to May 2021. Included studies investigated the use of CAM to treat adverse effects of cancer treatment in childhood cancer. Results: Fifteen studies were included in this review. Ten quasi-experimental, 3 observational studies (longitudinal/prospective), 2 qualitative studies, and 1 study with a quasi-experimental and qualitative arm were identified. Less than half (n = 6; 40%) of the studies included reported adverse effects for the CAM modality being studied. Among the studies that reported adverse effects, they were mostly considered as direct risk, as 13% reported mainly bleeding and bruising upon acupuncture treatment, and dizziness with yoga treatment. All adverse effects were assessed as minor and transient. CAM modalities identified for treating adverse effects of cancer treatment were alternative medical systems, manipulative and body-based therapies, biologically-based therapies, and mind-body therapies. CAM modalities were used to alleviate anxiety, pain, toxicity, prevent trauma, and improve health-related quality of life, functional mobility, and physical activity levels. All studies assessed scored 70% or above according to the Joanna Briggs Institute critical appraisal for study quality checklists. Conclusion: Most of the studies (58.3%) included in this review did not report adverse effects from CAM modalities used to treat adverse effects of cancer treatment in children and young adults. This lack of safety information is of concern because parents need to know whether the modality represents an extra burden or harm to the child. To improve awareness about safety in the field, a universal and uniform reporting system for adverse effects in CAM research is needed.

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“…Consumers are turning increasingly toward food supplements to improve well-being when pharmaceuticals fail [2,3]. Nowadays, nutraceuticals have received considerable interest due to their potential nutritional, safety, and therapeutic effects [4,5]. According to previous studies, many medicinal plants such as fenugreek, sumac, dill, ginger, grape, and green tea improve the lipid profile significantly [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular Effects of Cydonia oblonga Miller (Quince)

Amerizadeh

Vaseghi

Esmaeilian

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Cydonia oblonga Miller (quince) is a monotypic genus in the Rosaceae family which used to treat or prevent many medical conditions such as diabetes, cancer, infections, and ulcer. This review will summarize the current state of knowledge available on botany, phytochemistry, and pharmacology of this plant with a focus on its effect on some cardiovascular risk factors such as diabetes, blood pressure, lipid profile, and body weight. Databases of Google Scholar, Web of Science, PubMed, Scopus, and SID were searched systematically for English published articles with no date limitation. There were no human studies found, and all of the studies were conducted on animals or in vitro models. Reviewing of all 12 included articles showed that different types of quince extract have positive effects on cardiovascular-related factors such as blood pressure, diabetes, glucose metabolism, lipid profile, ROS, body weight, liver dysfunction, and thrombosis. An antihypertensive effect of quince showed to be a magnitude that is comparable to captopril and the lipid-lowering effect of quince showed to be a magnitude that is comparable to simvastatin. However, two studies evaluated the effect of quince fruit extract on insulin levels; one of them reported no positive effect, and the other one reported a significant positive effect. It can be concluded that different parts of quince including leaf, seed, and fruit could be used for improving cardiovascular-related factors including blood pressure, glucose metabolism and diabetes, obesity, and lipid-adjusting purposes. Quince was also found to have strong anti-inflammatory and antioxidant capacity. This study paves the way for further studies on the cardiovascular effect of quince consumption as a beneficial nutraceutical in humans.

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Complementary and alternative medicine modalities used to treat adverse effects of anti-cancer treatment among children and young adults: a systematic review and meta-analysis of randomized controlled trials

Cited by 15 publications

References 55 publications

Supportive care for cancer-related symptoms in pediatric oncology: a qualitative study among healthcare providers

Supportive care for cancer-related symptoms in pediatric oncology: a qualitative study among healthcare providers

Safety of Complementary and Alternative Medicine (CAM) treatment among children and young adults who suffer from adverse effects of conventional cancer treatment: A systematic review

Cardiovascular Effects of Cydonia oblonga Miller (Quince)

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