Complementary and alternative medicine for alopecia areata: A systematic review

Tkachenko, Elizabeth; Okhovat, Jean-Phillip; Manjaly, Priya; Huang, Kathie P.; Senna, Maryanne M.; Mostaghimi, Arash

doi:10.1016/j.jaad.2019.12.027

Cited by 21 publications

(25 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a recent SLR and meta-analysis, Okhovat et al reported that AA is positively associated with anxiety (pooled odds ratio [OR] 2.5; 95% confidence interval [CI] 1.5–4.1) and depression (pooled OR 2.7; 95% CI 1.5–4.8) [ 3 ]. Results from the current SLR support those findings, but also suggest that in many patients, AA also has a substantial impact on HRQoL in the domains of personality, emotions, behavior and social functioning, and may be accompanied by acute stress and alexithymia.…”

Section: Discussionmentioning

confidence: 99%

“…Our preregistered protocol also included studies evaluating the economic impact of AA, as well as anxiety and depression in AA. However, due to the scarcity of literature on the economic aspects of AA and the recent publication of a meta-analysis of anxiety and depression in AA [ 3 ], this report focuses on the social, emotional and functional impacts of AA on patients and does not include economic impacts of depression and anxiety.…”

Section: Methodsmentioning

confidence: 99%

“…The incidence of major depression in patients with AA has been reported as 8.8% compared with 1.3–1.5% in the general population, and generalized anxiety disorder has been reported in 18.2% compared with 2.5%, respectively [ 1 ]. Although psychiatric diagnoses preceded AA in approximately half the patients, in other patients AA appears to contribute to the development of depression and anxiety [ 1 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Patient Perspectives of the Social, Emotional and Functional Impact of Alopecia Areata: A Systematic Literature Review

Mostaghimi

Napatalung

Sikirica

et al. 2021

Dermatol Ther (Heidelb)

Self Cite

View full text Add to dashboard Cite

Introduction: Alopecia areata (AA) is a chronic, autoimmune disease of hair loss, which can significantly affect the emotional and psychological well-being of patients. A systematic literature review was conducted to better understand the burden of AA from the patient perspective. Methods: Embase, MEDLINE and Cochrane databases were searched for published studies (2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018) reporting on assessments of health-related quality of life (HRQoL) for patients with AA. Qualitative, and quantitative data were collected. Results: The review included 37 studies encompassing a range of clinical outcome assessment (COA) tools. None of the COA tools were specific for AA, and only one study used the Hairdex scale, which was designed to evaluate HRQoL in patients with disorders of the hair and scalp. All studies reported substantial impact on HRQoL due to AA, both overall and in domains related to personality (i.e. temperament and character), emotions and social functioning. Acute stress was also noted, and several studies identified lack of emotional awareness (alexithymia) in 23-50% of the patients with AA. Conclusions: Although it is well-established that patients with AA experience anxiety and depression, they also experience a decrease in HRQoL in many other areas, including personality, emotions, behaviors and social functioning, and these changes may be accompanied by acute stress and alexithymia. There is a need to achieve consensus on a core set of measures for AA and to develop and validate AA-specific measurement tools for use in future studies, to attain a clearer understanding of the impact of AA on patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Patient Perspectives of the Social, Emotional and Functional Impact of Alopecia Areata: A Systematic Literature Review

Mostaghimi

Napatalung

Sikirica

et al. 2021

Dermatol Ther (Heidelb)

Self Cite

View full text Add to dashboard Cite

show abstract

“…Total glucosides of peony (TGP) are used to treat rheumatoid arthritis and systemic lupus erythematosus [ 1 ] as well as hepatitis, dysmenorrhea, muscle cramps, and spasms. The active components of TGP include monoterpene glycosides, galloyl glucoses, and phenolic compounds [ 2 ]. In long-term clinical use, TGP have therapeutic effects and no severe side effects [ 3 – 5 ].…”

Section: Introductionmentioning

confidence: 99%

Total Glucosides of Peony Protect Cardiomyocytes against Oxidative Stress and Inflammation by Reversing Mitochondrial Dynamics and Bioenergetics

Wang

Zhang

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Total glucosides of peony (TGP) are used to treat rheumatoid arthritis and systemic lupus erythematosus. We explored the protective effects of TGP on cardiomyocyte oxidative stress and inflammation in the presence of hydrogen peroxide by focusing on mitochondrial dynamics and bioenergetics. Our study demonstrated that hydrogen peroxide significantly repressed cardiomyocyte viability and promoted cell apoptosis through induction of the mitochondrial death pathway. TGP treatment sustained cardiomyocyte viability, reduced cardiomyocyte apoptosis, and decreased inflammation and oxidative stress. Molecular investigation indicated that hydrogen peroxide caused mitochondrial dynamics disruption and bioenergetics reduction in cardiomyocytes, but this alteration could be normalized by TGP. We found that disruption of mitochondrial dynamics abolished the regulatory effects of TGP on mitochondrial bioenergetics; TGP modulated mitochondrial dynamics through the AMP-activated protein kinase (AMPK) pathway; and inhibition of AMPK alleviated the protective effects of TGP on mitochondria. Our results showed that TGP treatment reduces cardiomyocyte oxidative stress and inflammation in the presence of hydrogen peroxide by correcting mitochondrial dynamics and enhancing mitochondrial bioenergetics. Additionally, the regulatory effects of TGP on mitochondrial function seem to be mediated through the AMPK pathway. These findings are promising for myocardial injury in patients with rheumatoid arthritis and systemic lupus erythematosus.

show abstract

“…According to the latest consensus classification, the combination of a dominant and recessive COL7A1 mutation is supposed to cause a severe form of DEB. 1 The data from the family presented here demonstrate that such a genotype can also cause mild(er) DEB phenotypes,…”

Section: Irb Approval Statusmentioning

confidence: 61%

A nationwide multicentre cross‐sectional questionnaire study on the use of non‐dermatologic facilities among patients with hair loss

Choi

Kim

Lew

et al. 2021

Acad Dermatol Venereol

View full text Add to dashboard Cite

Complementary and alternative medicine for alopecia areata: A systematic review

Cited by 21 publications

References 52 publications

Patient Perspectives of the Social, Emotional and Functional Impact of Alopecia Areata: A Systematic Literature Review

Patient Perspectives of the Social, Emotional and Functional Impact of Alopecia Areata: A Systematic Literature Review

Total Glucosides of Peony Protect Cardiomyocytes against Oxidative Stress and Inflammation by Reversing Mitochondrial Dynamics and Bioenergetics

A nationwide multicentre cross‐sectional questionnaire study on the use of non‐dermatologic facilities among patients with hair loss

Contact Info

Product

Resources

About