Abstract:To assess relationships between neuropeptide-binding sites and receptor proteins in rat brain, the distribution of radioautographically labeled somatostatin and neurotensin-binding sites was compared to that of immunolabeled sst2A and NTRH receptor subtypes, respectively. By light microscopy, immunoreactive sst2A receptors were either confined to neuronal perikarya and dendrites or diffusely distributed in tissue. By electron microscopy, areas expressing somatodendritic sst2A receptors displayed only low propo… Show more
“…Despite these limitations, development of radioactive chemical ligands specific for a given receptor class became an efficient tool to identify, map and quantify neurotransmitter receptors in tissue sections in discrete brain areas (Chabot et al 1996;Beaudet et al 1998). Ligands (either agonists or antagonists) can be labelled with radioactive atoms and demonstrated all abilities to bind to receptors in tissue sections with appropriate pharmacological parameters.…”
“…Despite these limitations, development of radioactive chemical ligands specific for a given receptor class became an efficient tool to identify, map and quantify neurotransmitter receptors in tissue sections in discrete brain areas (Chabot et al 1996;Beaudet et al 1998). Ligands (either agonists or antagonists) can be labelled with radioactive atoms and demonstrated all abilities to bind to receptors in tissue sections with appropriate pharmacological parameters.…”
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