1996
DOI: 10.1007/bf01367593
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Abstract: Radionuclide scanning with tumour-seeking agents such as pentavalent technetium-99m dimercaptosuccinic acid [99mTc(V)-DMSA], thallium-201 and technetium-99m sestamibi (MIBI) has been reported to be useful in the detection of medullary thyroid carcinoma (MTC). We undertook a study in 14 MTC patients to determine the comparative imaging potential of 201Tl, MIBI and 99mTc(V)-DMSA in the detection of recurrent or metastatic MTC. All patients underwent total thyroidectomy and had persistently elevated serum calcito… Show more

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Cited by 72 publications
(26 citation statements)
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“…Bone scans are generally better for imaging bone lesions. Several other imaging techniques, e.g., thallium-201 thallous chloride ( 201 TICI), technetium-99m pentavalent dimercaptosuccinic acid ( 99m Tc(V)-DMSA), or 99m Tc-tetrofosmin have been analyzed (Adalet et al 1999;Ugur et al 1996) and were found to be complementary, often having a high sensitivity but a low speci®city. Octreotide scans have been shown to be quite sensitive in detecting lung metastases; however, this technique fails to visualize tumors less than 1 cm.…”
Section: Genotype-phenotype Correlationmentioning
confidence: 99%
“…Bone scans are generally better for imaging bone lesions. Several other imaging techniques, e.g., thallium-201 thallous chloride ( 201 TICI), technetium-99m pentavalent dimercaptosuccinic acid ( 99m Tc(V)-DMSA), or 99m Tc-tetrofosmin have been analyzed (Adalet et al 1999;Ugur et al 1996) and were found to be complementary, often having a high sensitivity but a low speci®city. Octreotide scans have been shown to be quite sensitive in detecting lung metastases; however, this technique fails to visualize tumors less than 1 cm.…”
Section: Genotype-phenotype Correlationmentioning
confidence: 99%
“…Ultrasound, CT, and MRI provide structural but no functional information. Conventional nuclear medicine studies with 99m Tc (V) dimercaptosuccinic acid, 99m Tc-sestamibi, 111 In-pentetreotide, and 131 I-metaiodobenzylguanidine have variable and often limited sensitivity (9)(10)(11)(12). The advent of 18 F-FDG PET added another imaging tool in the detection of recurrent MTC.…”
mentioning
confidence: 99%
“…Extensive diagnostic work-ups including MRI, CT, and a variety of nuclear scans in patients with metastatic MTC have revealed predominantly local soft tissue involvement. 26 In this other study, bone and lung metastases also were seen, but the study failed to show liver metastases. These findings indicate a higher probability for the presence of clinically occult nodal metastases in patients with persistent calcitonin elevations and in the absence of clinically detectable disease.…”
Section: Discussionmentioning
confidence: 88%