Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2012.03.064 View full text
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Gaurav Agrawal, Yoshiaki Kawajiri

Abstract: Over the past decade, many modifications have been proposed in simulated moving bed (SMB) chromatography in order to effectively separate a binary mixture. However, the separation of multi-component mixtures using SMB is still one of the major challenges. In addition, the performance of SMB system highly depends on its operating conditions. Our study address this issue by formulating a multi-objective optimization problem that maximizes the productivity and purity of intermediate eluting component at the same …

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