Tenth-order compact difference code Miranda is used to perform large-eddy simulation (LES) of a hydrogen gas/plastic mixing layer in a spherical geometry. Once the mixing layer has achieved selfsimilar growth, it is heated to 1 keV, and the second-order arbitrary Lagrangian/Eulerian (ALE) code Ares is used to simulate mixing layer evolution as it undergoes thermonuclear (TN) burn. Both premixed (in which deuterium and tritium are initially present in the gas) and non-premixed (in which deuterium is initially present only in the plastic) variants are considered at Atwood numbers 0.05 and 0.50. The impact of turbulent mixing on mean TN reaction rate is examined, and a four-equation k-L-a-V Reynolds-averaged Navier Stokes (RANS) model is presented. The k-L-a-V model, which represents an extension of the k-L-a model [B. Morgan and M. Wickett, "Three-equation model for the self-similar growth of Rayleigh-Taylor and Richtmyer-Meshkov instabilities," Phys. Rev. E 91, 043002 (2015)] by the addition of a transport equation for the scalar mass fraction variance, is then applied in one-dimensional simulations of the reacting mixing layer under consideration. Excellent agreement is obtained between LES and RANS in total TN neutron production when fluctuations in reaction cross-section can be neglected.