Comparison of Treatment Modalities for Epidermal Nevus: A Case Report and Review

Fox, Barbara J.; Lapins, Nikolajs A.

doi:10.1111/j.1524-4725.1983.tb01035.x

Cited by 64 publications

(47 citation statements)

References 19 publications

(41 reference statements)

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“…Although, several treatment modalities have been reported for the cutaneous lesions, such as surgical excision, laser ablation, cryotherapy, dermabrasion, chemical peels, topical corticosteroids and systemic steroids, no information are available for oral lesions [19,20]. In our Case 2 the surgical removal of the palatal nodule was not followed by recurrence, according to the outcomes of other Authors [6,9].…”

Section: Discussionmentioning

confidence: 75%

Oral Linear Epidermal Nevus: A Review of the Literature and Report of Two New Cases

Tesi

Ficarra

2010

Head and Neck Pathol

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Linear epidermal nevus (LEN) is a sporadic hamartomatous lesion of the skin due to the proliferation of clones of embryonic ectodermal cells, which are arranged according to a typical linear configuration known as Blaschko's lines. Oral involvement of LEN is very rare and few cases have been reported in the medical literature. We report two new cases of LEN with exclusive oral involvement, which presented with the typical unilateral or midline distribution. Oral LEN presents as an exophytic lesion with well defined borders and a verrucous or papillary surface which correspond, histologically, to epithelial papillomatosis with a moderate degree of hyperkeratosis and acanthosis. Oral LEN appears mainly at birth, grows slowly during childhood and stabilize by adolescence. Localized lesions do not show any recurrence after surgical removal but widespread lesions seem to have more risk of recurrence and are more difficult to manage. Functional problems and malignant transformation have not been reported.

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Section: Discussionmentioning

confidence: 75%

Oral Linear Epidermal Nevus: A Review of the Literature and Report of Two New Cases

Tesi

Ficarra

2010

Head and Neck Pathol

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“…ILVEN is relatively difficult to treat. Partial improvement however has been reported with topical and intralesional high-potency corticosteroids [2, 9-11], reti noids [12], podophyllin ointment [13] and cryotherapy [10], Familial occurrences of ILVEN have also been reported [8, 14,15]. The mother and daughter described by Hamm and Happle [8] had a bilateral systemized distribu tion of verrucous lesions similar to our patients, and systemized linear lesions similar to ILVEN have been reported in a girl whose sister had the polydysplastic CHILD syndrome.…”

Section: Discussionmentioning

confidence: 99%

Adult Onset of Inflammatory Linear Verrucous Epidermal Nevus in a Mother and Her Daughter

Goldman

Don²

1994

Dermatology

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Inflammatory linear verrucous epidermal nevus (ILVEN) is a rather uncommon dermatosis that typically has an early age of onset, is unilateral, localized, pruritic and relatively refractory to treatment. Atypical presentations of ILVEN have also been described and include late onset in life, widespread involvement and response to treatment. We report the adult onset of an extremely pruritic systemized eruption in both mother and her daughter that clinically and histologically was most compatible with ILVEN. The eruptions were also partially responsive to therapy.

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“…In 1983, Fox and Lapins [3] applied various approaches to treating epidermal nevi on one patient who had extensive, disfiguring epidermal nevus lesions. They concluded that cryosurgery using liquid nitrogen was the most successful therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Topical modalities, including steroids (topical or intralesional), retinoids, calcipotriol, toxins (e.g. podophyllin), antiproliferatives (5-fluorouracil cream), keratolytics, and chemical peels, have shown inconsistent efficacy and a high rate of recurrence, and destructive methods, including laser, electrocoagulation, and dermabrasion, have not uniformly provided acceptable efficacy and side effects and a high rate of recurrence [3,4,5,6,7,8,9,10,11]. Surgery is an option for small lesions, but in large lesions the scar is not necessarily a worthwhile trade-off.…”

Section: Introductionmentioning

confidence: 99%

Treatment of Verrucous Epidermal Nevus: Experience with 71 Cases

et al. 2013

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Objective: The aim of this study was to evaluate the clinical results of 71 cases with verrucous epidermal nevus (VEN) treated by cryotherapy or CO₂ laser. Methods: The files and photographs of patients with VEN who were treated in the laser unit of a tertiary hospital between January 2005 and December 2011 were evaluated. Pretreatment and 12-month follow-up photographs were evaluated using a 5-point scale: ‘excellent' (75-100% clearance), ‘good' (50-75% clearance), ‘fair' (25-50% clearance), ‘poor' (<25% clearance) or ‘worse'. Results: Of 71 patients, 62 responded well to cryotherapy alone, and 9 facial VEN required CO₂ laser treatment. Small VEN required relatively few treatments (mean 3.4) with 90% scoring ‘excellent' and 10% scoring ‘good'. Larger VEN required more treatments (mean 7.4) and did not respond as well, with 71% scoring ‘excellent', 14% scoring ‘good' and 14% scoring ‘fair'. Conclusion: Our experience suggests that cryotherapy is the ideal treatment for small facial VEN, while ablation by CO₂ laser should be considered an option for resistant facial lesions.

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Comparison of Treatment Modalities for Epidermal Nevus: A Case Report and Review

Cited by 64 publications

References 19 publications

Oral Linear Epidermal Nevus: A Review of the Literature and Report of Two New Cases

Oral Linear Epidermal Nevus: A Review of the Literature and Report of Two New Cases

Adult Onset of Inflammatory Linear Verrucous Epidermal Nevus in a Mother and Her Daughter

Treatment of Verrucous Epidermal Nevus: Experience with 71 Cases

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