Comparison of the long-term effects of single-dose methotrexate and salpingectomy on ovarian reserve in terms of anti-müllerian hormone levels

Ersoy, Gülçı̇n Şahin; Turhan, Ömer; Sakin, Önder; Bulut, Sadullah

doi:10.1080/14647273.2016.1214755

Cited by 9 publications

(27 citation statements)

References 35 publications

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“…Pooled analysis of group 1 studies ( n = 464) revealed no statistically significant change in serum AMH levels after salpingectomy (WMD −0.10 ng/mL; 95% CI −0.19 to 0.00, I 2 = 0%) with low heterogeneity between studies (Figure ) . Similarly, in group 2, overall analysis of two studies showed no statistically significant difference between the salpingectomy group ( n = 169) and control group ( n = 154) (WMD −0.11 ng/mL; 95% CI −0.37 to 0.14, I 2 = 77%) with high heterogeneity between studies (Figure ) .…”

Section: Resultsmentioning

confidence: 98%

“…In group 1, pooled analysis of three studies including 96 participants aged <40 years revealed no statistically significant change in serum AMH level (WMD −0.05 ng/mL; 95% CI −0.47 to 0.57; I 2 = 0%) . In group 2 studies, all participants were aged <40 years and a sub‐analysis was therefore not performed .…”

Section: Resultsmentioning

confidence: 99%

“…In four studies, participants had normal fallopian tubes, which were removed during a gynecological procedure including hysterectomy , myomectomy or sterilization . In three other studies, participants underwent salpingectomy due to tubal ectopic pregnancy . In the remaining study, women underwent salpingectomy due to tubal pathology including tubo‐ovarian abscess, ectopic pregnancy or hydro‐salpinx .…”

Section: Resultsmentioning

confidence: 99%

“…To date, there are several studies evaluating the effect of salpingectomy on ovarian reserve (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). Given the small size of these studies, further evidence is required to address this important topic.…”

Section: Key Messagementioning

confidence: 99%

“…All participants underwent salpingectomy through laparoscopy except in two studies, which included women undergoing salpingectomy through laparotomy or laparoscopy (15,21). All studies specified the laterality of salpingectomy, which was bilateral in four studies (9,10,12,21) and unilateral in three studies (11,14,15). The remaining study compared unilateral and bilateral salpingectomy (13).…”

Section: Salpingectomy Surgerymentioning

confidence: 99%

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Ovarian reserve after salpingectomy: a systematic review and meta‐analysis

Mohamed

Yosef

James³

et al. 2017

Acta Obstet Gynecol Scand

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Introduction. Although there has been a growing concern over the possible damaging effect of salpingectomy on ovarian reserve, this issue remains uncertain. The purpose of this meta-analysis was to test the hypothesis that salpingectomy may compromise ovarian reserve. Material and methods. A detailed search was conducted using MEDLINE, Embase, Dynamed Plus, ScienceDirect, TRIP database and the Cochrane Library from January 2000 to November 2016. All cohort, cross-sectional and randomized controlled studies investigating changes in circulating anti-M€ ullerian hormone (AMH) after salpingectomy were considered. Thirty-seven studies were identified, of which eight were eligible. Data were extracted and entered into REVMAN software for calculation of the weighted mean difference (WMD) and 95% CI. Two groups of studies were analyzed separately: group 1 (six studies, n = 464) comparing data before and after salpingectomy and group 2 (two studies) comparing data in women who have undergone salpingectomy (n = 169) vs. healthy controls (n = 154). Results. Pooled results of group 1 studies showed no statistically significant change in serum AMH concentration after salpingectomy (WMD, À0.10 ng/mL; 95% CI À0.19 to 0.00, I 2 = 0%). Similarly, meta-analysis of group 2 showed no statistically significant difference in serum AMH concentration between salpingectomy group and controls (WMD, À0.11 ng/ mL; 95% CI À0.37 to 0.14, I 2 = 77%). Subgroup analyses based on laterality of surgery, type of AMH kit and participants' age (<40 years) still showed no statistically significant changes in circulating AMH. Conclusion. Salpingectomy does not seem to compromise ovarian reserve in the short-term. However, the long-term effect of salpingectomy on ovarian reserve remains uncertain.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Key Messagementioning

confidence: 99%

Section: Salpingectomy Surgerymentioning

confidence: 99%

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Ovarian reserve after salpingectomy: a systematic review and meta‐analysis

Mohamed

Yosef

James³

et al. 2017

Acta Obstet Gynecol Scand

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Management of Hydrosalpinx in the Era of Assisted Reproductive Technology: A Systematic Review and Meta-analysis

Capmas

Suarthana

Tulandi

2021

Journal of Minimally Invasive Gynecology

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To conduct a systematic review and meta-analysis evaluating the effect of hydrosalpinx on pregnancy outcomes, to compare different types of management of hydrosalpinx and their impact on pregnancy rates as well as on the ovarian reserve. Data Sources: Electronic search using Pubmed, EMBASE, Ovid MEDLINE, Google Scholar, ClinicalTrials.gov, and Cochrane Central Register of Controlled Trials and including all published studies that examined tubal infertility and its management (assisted reproductive technology or surgery) as well as the effects on ovarian reserve. The following medical subject headings (Mesh) terms combinations were used: "fallopian tube disease," hydrosalpinx," "tubal or salpinx occlusion or obstruction," "in vitro fertilization," "fallopian tube surgery," "salpingectomy," "salpingostomy," "infertility," "subfertility," "sterility" and "ovarian reserve." Methods of Study Selection: All randomized trials, cohort, and case controls studies were included. We excluded review articles, meeting abstracts, case series and case reports, and abstracts without access to full texts. The search was limited to trials in humans and published in English. Tabulation, Integration, and Results: Our electronic search initially retrieved 6354 articles. Finally, 19 studies were included in the quantitative evaluation of the effects of hydrosalpinx: 23 in the qualitative evaluation and 5 in the quantitative evaluation of different types of hydrosalpinx treatments; and 17 in the quantitative evaluation of ovarian reserve. The presence of a hydrosalpinx was associated with decreased rates of implantation and clinical pregnancy, and increased rates of ectopic pregnancy and miscarriage. Management of hydrosalpinx with salpingectomy, tubal occlusion, or hydrosalpinx aspiration led to better in vitro fertilization pregnancy rates. We found no difference in ovarian response to stimulation after salpingectomy except a decrease in antim€ ullerian hormone compared to no surgery. Conclusions: The presence of hydrosalpinx is associated with decreased pregnancy rate and increased rates of ectopic pregnancy and miscarriage. Management of hydrosalpinx, regardless of the type of treatment, leads to an increased chance of pregnancy.

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