Comparison of the General Threshold Model of Survival and Dose–Response Models in Simulating the Acute Toxicity of Metals to Danio rerio

Abstract

We exposed zebrafish (Danio rerio) to different concentrations of lead and cadmium, and monitored them for survival at 24, 48, 72, and 96 h. Metal toxicity was predicted and compared using the dose–response and general threshold survival models in terms of required data sets, fit performance, and applicability. Environ Toxicol Chem 2019;38:2169–2177. © 2019 SETAC.

Application of General Unified Threshold Models to Predict Time-Varying Survival of Mayfly Nymphs Exposed to Three Neonicotinoids

“…They demonstrated this by using the dataset of Nyman et al [35], in which the survival of the crustacean Gammarus pulex exposed to the azole fungicide propiconazole was assessed. He et al [36] also concluded that there was a negligible difference between the experimentally observed survival and predictions by the GUTS for zebrafish (Danio rerio) exposed to metals. Subsequently, the GUTS framework has been demonstrated to be an accurate tool for several compounds [36].…”

“…He et al [36] also concluded that there was a negligible difference between the experimentally observed survival and predictions by the GUTS for zebrafish (Danio rerio) exposed to metals. Subsequently, the GUTS framework has been demonstrated to be an accurate tool for several compounds [36]. However, as the EFSA [18] also discussed, doubts remain regarding the predictive power of the GUTS framework for compounds that show increased toxicity over time, such as neonicotinoids.…”