Identificationo fs accharides is difficult due to their similar chemical structure. However,t hey interact very selectively with lanthanide probes. To explore the potential for saccharide recognition, we compare circularly polarized luminescence induced by av ariety of oligo-and polysaccharides in three europium compounds. Measurement on a standard Ramano pticala ctivity spectrometer made it possible to use high excitation powers and provided very distinct spectralp atterns,w hich were sensitive both to the local structure and differences in molecular size. For example, a-, b-a nd g-cyclodextrins provided unique spectroscopic responses.T itration data and molecular dynamics simulation confirmed that CPL spectra carry information about the bindingm ode and strength between the lanthanide probe and saccharide skeleton.[a] Dr.