Comparison of the efficacy of medium chain triglycerides with long chain triglycerides in total parenteral nutrition in patients with hematologic malignancies undergoing peripheral blood stem cell transplantation

Demirer, Seher; Üstün, Celalettin; Türkmen, Esma; Tüzün, Ali; Şimsek, Ş.; Başaran, Ö.; Çelebi, Harika; Demirer, Taner

doi:10.1054/clnu.2000.0101

Cited by 11 publications

(6 citation statements)

References 30 publications

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“…Previous studies have shown the impact of PN on coagulation parameters, including TT, PT, aPTT, Fib, antithrombin III, and factors VIIa and XIIa 15 , 17 . The impact on platelet functions, including platelet aggregation, platelet protein, platelet factor4, and 6‐keto prostaglandin F1α 18 ‐ 20 and fatty acid composition of individual phospholipids in the platelets 19 ‐ 21 have been investigated. However, to our knowledge, there have been no reports on the effect of PN on platelet membrane GP, which mediates a wide variety of cell–cell and cell–substrate adhesions.…”

Section: Discussionmentioning

confidence: 99%

Activation of Platelet Membrane Glycoprotein Induced by Parenteral Nutrition

Li¹,

Wan²,

Xia

et al. 2011

J Parenter Enteral Nutr

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One of the most frequent complications observed in patients with intestinal failure who require parenteral nutrition (PN) is catheter-related thrombosis (CRT). The current measurements for CRT is to reduce endothelial trauma. In this paper, the possible role of PN on thrombosis besides catheter is explored. Although only a preliminary report, these results suggest that modifying the composition of PN could potentially be an effective strategy for CRT. IntroductionIntestinal failure has been defined as the reduction of functional gut mass below the minimal amount necessary From the

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Section: Discussionmentioning

confidence: 99%

Activation of Platelet Membrane Glycoprotein Induced by Parenteral Nutrition

Li¹,

Wan²,

Xia

et al. 2011

J Parenter Enteral Nutr

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“…On the other hand, both healthy donors and patients who received the lipid emulsion MCT/LCT (50%/50%) showed no change in the coagulation tests, including PT, PTT, fibrinogen, TT ( 64 ) . Furthermore, the comparison of MCT/LCT (50%/50%) and SO (100% LCT) lipid emulsions did not differ in coagulation parameters, including PT, PTT, and fibrinogen levels ( 71 ) (Table 3 ).…”

Section: Impact Of Pn Lipid Emulsions On Platelet Function Platelet C...mentioning

confidence: 95%

“…Similarly, the lipid emulsion MCT/LCT (50%/50%) did not differ in platelet engraftment in patients with various haematologic malignancies who underwent a haematopoietic peripheral blood stem cell transplantation ( 71 ) . Thus, MCT/LCT (50%/50%) may protect against thrombocytopenia.…”

Section: Impact Of Pn Lipid Emulsions On Platelet Function Platelet C...mentioning

confidence: 96%

Impact of lipid emulsions in parenteral nutrition on platelets: a literature review

Kisioglu,

Tamer

2024

J Nutr Sci

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Lipid emulsions are essential components of parenteral nutrition solutions that provide energy and essential fatty acids. The complexity of the formulations of lipid emulsions may lead to adverse outcomes such as platelet reactivity and changes in platelet aggregation and related coagulation. Platelets are responsible for haemostasis; they activate and demonstrate morphological changes upon extracellular factors to maintain blood fluidity and vascular integrity. Although parenteral nutrition lipid emulsions are generally found safe with regard to modulation of platelet activity, studies are still accumulating. Thus, this review aims to investigate platelet-related changes by parenteral nutrition lipid emulsions in human studies. Studies have pointed out patients at risk of bleeding and increased platelet aggregation responses due to the administration of lipid emulsions. Lipid emulsions may further benefit patients at high risk of thrombosis due to anti-thrombotic effects and should be cautiously used in patients with thrombocytopenia. The reported platelet-related changes might be associated with the fatty acid change in the plasma membranes of platelets following changes in platelet synthesis and plasma levels of eicosanoids. In conclusion, studies investigating platelets and parenteral nutrition should be supported to minimize the adverse effects and to benefit from the potential protective effects of parenteral nutrition lipid emulsions.

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“…In patients after stem cell transplantations for malignant haematological disorders, the use of the mixed soybean oil/MCT emulsion (n=18) resulted in a higher number of days with pyrexia (10 versus 7, p=0.01), and days on antibiotics (12 versus 8, p=0.04) as compared to a 100% soybean oil emulsion (n=18). Other end points, such as the occurrence of Graft versus Host Disease (GVHD) and mortality, were not different ([84]; Ib). The use of an experimental soybean oil/MCT emulsion in a 25/75 ratio resulted in significantly higher resting energy consumption, oxygen consumption and carbon dioxide production, as a result of higher thermogenetic effect of MCT as compared to a 100% soybean oil emulsion [85].…”

Section: Available Lipid Emulsionsmentioning

confidence: 99%