Comparison of the efficacy of single or repeated HI-6 treatment following soman poisoning in guinea pigs and marmoset

Transdermal Penetration of the Acetylcholinesterase Reactivator Hi-6 in a Rat Model

“…The dose of HI-6 proposed for a human, used from one autoinjector containing 500 mg of HI-6 2Cl, produced peak plasma levels of 15 µg/ml in a man [15]. Plasma levels of HI-6 even as high as 170-180 µg/ml have been reported to produce protection against supra lethal doses of soman [16]. For this reason, HI-6 in levels of about 0.0625 µg/ml (the detection limit of the method) are expected not to be sufficient for protection against OPs and measured plasma levels were even lower.…”

Transdermal Penetration of the Acetylcholinesterase Reactivator Hi-6 in a Rat Model

“…The dose of HI-6 proposed for a human, used from one autoinjector containing 500 mg of HI-6 2Cl, produced peak plasma levels of 15 µg/ml in a man [15]. Plasma levels of HI-6 even as high as 170-180 µg/ml have been reported to produce protection against supra lethal doses of soman [16]. For this reason, HI-6 in levels of about 0.0625 µg/ml (the detection limit of the method) are expected not to be sufficient for protection against OPs and measured plasma levels were even lower.…”

Effects of VX on Acoustic Startle Response and Acquisition of Operant Behavior in Rats

“…However, it appears there are species differences between rodents with regard to the effects of cholinesterase inhibition on startle response. In rats and mice [10,11,21,24], startle reactions decrease in response to acetylcholinesterase (AChE) inhibition, whereas in guinea pigs startle reactions tend to increase in response to AChE inhibition [8,13,[33][34][35][36]46].…”

The Toxicity of Soman in the African Green Monkey (Chlorocebus aethiops)

“……”

Transdermal Penetration of the Acetylcholinesterase Reactivator Hi-6 in a Rat Model

“…The dose of HI-6 proposed for a human, used from one autoinjector containing 500 mg of HI-6 2Cl, produced peak plasma levels of 15 µg/ml in a man [15]. Plasma levels of HI-6 even as high as 170-180 µg/ml have been reported to produce protection against supra lethal doses of soman [16]. For this reason, HI-6 in levels of about 0.0625 µg/ml (the detection limit of the method) are expected not to be sufficient for protection against OPs and measured plasma levels were even lower.…”

Effects of VX on Acoustic Startle Response and Acquisition of Operant Behavior in Rats

“…However, it appears there are species differences between rodents with regard to the effects of cholinesterase inhibition on startle response. In rats and mice [10,11,21,24], startle reactions decrease in response to acetylcholinesterase (AChE) inhibition, whereas in guinea pigs startle reactions tend to increase in response to AChE inhibition [8,13,[33][34][35][36]46].…”

The Toxicity of Soman in the African Green Monkey (Chlorocebus aethiops)

“……”

Transdermal Penetration of the Acetylcholinesterase Reactivator Hi-6 in a Rat Model

“…The dose of HI-6 proposed for a human, used from one autoinjector containing 500 mg of HI-6 2Cl, produced peak plasma levels of 15 µg/ml in a man [15]. Plasma levels of HI-6 even as high as 170-180 µg/ml have been reported to produce protection against supra lethal doses of soman [16]. For this reason, HI-6 in levels of about 0.0625 µg/ml (the detection limit of the method) are expected not to be sufficient for protection against OPs and measured plasma levels were even lower.…”

Effects of VX on Acoustic Startle Response and Acquisition of Operant Behavior in Rats

“…However, it appears there are species differences between rodents with regard to the effects of cholinesterase inhibition on startle response. In rats and mice [10,11,21,24], startle reactions decrease in response to acetylcholinesterase (AChE) inhibition, whereas in guinea pigs startle reactions tend to increase in response to AChE inhibition [8,13,[33][34][35][36]46].…”

The Toxicity of Soman in the African Green Monkey (Chlorocebus aethiops)

“……”