Comparison of the Effects of Matricaria chamomila (Chamomile) Extract and Mefenamic Acid on the Intensity of Mastalgia Associated With Premenstrual Syndrome

Sharifi, Farid; Simbar, Masoumeh; Mojab, Faraz; Majd, Hamid Alavi

doi:10.17795/whb-20042

Cited by 3 publications

(8 citation statements)

References 11 publications

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“…Most studies reported a cyclic mastalgia prevalence of about 30% in Iran [5,10,29]. The minimum and maximum rates were 23.8% and 60% respectively [30,31]. Age 30 was the most common age for cyclic mastalgia [3,5,10,27,28,30,34].…”

Section: Resultsmentioning

confidence: 99%

“…The minimum and maximum rates were 23.8% and 60% respectively [30,31]. Age 30 was the most common age for cyclic mastalgia [3,5,10,27,28,30,34]. This pain was more common in married people than single ones [7,10,14,29,30,31].…”

Section: Resultsmentioning

confidence: 99%

“…Age 30 was the most common age for cyclic mastalgia [3,5,10,27,28,30,34]. This pain was more common in married people than single ones [7,10,14,29,30,31]. Most studies found a significant relationship between premenstrual syndrome and this pain [29,30], but there was no significant relationship between the use of contraceptive pills and cyclic mastalgia [29,30].…”

Section: Resultsmentioning

confidence: 99%

“…This pain was more common in married people than single ones [7,10,14,29,30,31]. Most studies found a significant relationship between premenstrual syndrome and this pain [29,30], but there was no significant relationship between the use of contraceptive pills and cyclic mastalgia [29,30]. There were conflicting results regarding the duration of lactation and its possible effect on cyclic Mastodynia; some reported a significant correlation between them [29,34], while others reported no correlation [30].…”

Section: Resultsmentioning

confidence: 99%

“…Most studies found a significant relationship between premenstrual syndrome and this pain [29,30], but there was no significant relationship between the use of contraceptive pills and cyclic mastalgia [29,30]. There were conflicting results regarding the duration of lactation and its possible effect on cyclic Mastodynia; some reported a significant correlation between them [29,34], while others reported no correlation [30]. Several studies reported the significant positive relationship of length and severity of cyclic mastalgia with anxiety and depression [10,30].…”

Section: Resultsmentioning

confidence: 99%

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Cyclic Mastalgia in Iranian Women: A Review

Ghodsi

Olfati

Bahrami

et al. 2020

JQUMS

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Despite the high prevalence of cyclic mastalgia, there is much disagreement and uncertainties about its treatment methods. The present study aims to review studies conducted on cyclic mastalgia over the past two decades in Iran. In this regard, a search was conducted in Scopus, SID, PubMed, Google Scholar, ScienceDirect, and IranMedex databases on articles published in Persian and English from 1998 to 2018 using the following keywords: “Mastalgia”, “cyclic mastalgia”, “breast pain”, and “Mastodynia”. Initial search yielded 975 articles. Of these, 29 were selected for review based on inclusion criteria; 19 interventional and 10 non-interventional. Based on the results, most studies reported a mastalgia prevalence of about 30% in Iran. The most common age for cyclic mastalgia was 30 years. In most studies, a significant relationship between premenstrual syndrome and cyclic mastalgia was reported. The use of vitamins and herbal plants were the most common interventions for cyclic mastalgia, while counseling was the least common type. It seems that cyclic mastalgia affects the sleep quality and physical and sexual activities. Due to the high prevalence of cyclic mastalgia reported in various studies in Iran, and the lack a same treatment protocol, further study on cyclic mastalgia is recommended.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Cyclic Mastalgia in Iranian Women: A Review

Ghodsi

Olfati

Bahrami

et al. 2020

JQUMS

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Effectiveness of Matricaria chamomilla (chamomile) extract on pain control of cyclic mastalgia: a double-blind randomised controlled trial

Saghafi

Rhkhshandeh

Pourmoghadam

et al. 2017

Journal of Obstetrics and Gynaecology

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Breast pain (mastalgia) often precedes menstrual period, which is of mild to moderate severity. This study was performed to determine the effectiveness of chamomile on pain control of cyclic mastalgia. This double-blind randomised controlled clinical trial was conducted on 60 patients with mastalgia referred to the breast clinic of an academic hospital, Mashhad University of Medical Sciences. The patients were randomly allocated into two groups: chamomile (n = 30) and placebo (n = 30). Primary outcomes were: (1) assessment of the visual analogue scale (VAS) and (2) assessment of the breast pain chart (BPC) 8 weeks after initial intervention. All the participants were asked to take drops three times a day each time having five drops for two consecutive months. Significant decline was observed in both the groups (chamomile and placebo) after two months (p < .0001 and p = .048, respectively) compared to baseline and between two groups (p = .007). Chamomile was a well-tolerated, secure and effective drug for treating women with mild to moderate mastalgia. Impact statement What is already known on this subject: Breast pain (mastalgia) is a common chief complaint reported by many women. The 'cyclic' type, which usually occurs monthly prior to the onset of menstrual period, is of moderate severity. In 30% of the cases, mastalgia is severe and disturbs normal life, leading to sexual, physical, and social dysfunction as well as depression and anxiety. The cause of cyclical mastalgia is not known, but given the fact that it begins in the luteal phase, it can be caused by hormonal stimulation. A variety of therapies have been recommended. Such therapies include prescription of vitamin B2, B6, E and C, non-steroidal anti-inflammatory drugs (NSAIDs), diuretics, thyroxin, progesterone, Tamoxifen, Danazol, Bromocriptine and plant extracts like vitexagnus castus, evening primrose oil (EPO). However, given the side effects of hormonal treatment, many women have developed a propensity towards the use of herbal medicine. What do the results of this study add: Chamomile presents a safe, well-tolerated and effective treatment for women with moderate mastalgia. What are the implications of these finding for clinical practice and/or further research: Considering that Danazol, Bromocriptine and Tamoxifen are standard treatments for mastalgia, it would be helpful to carry out a trial study to compare the effect of chamomile extract versus standard treatments. The physicians can prescribe chamomile as a safe alternative treatment for mastalgia.

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Medicinal Properties of Chamomile against Dysmenorrhea

Khan¹,

Farooq

Khalid

2021

BJSTR

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Chamomile is sweet and small flowers which reduce inflammation in our body and it also have anticonvulsant properties. Matricaria Chamomile and Chamomile Recutita are the scientific name of Chamomile two species. Chamomile is also known as the miracle or medical plant because of its properties. Chamomile is used for different purpose like anti-diuretic, for treating stomach aches, reduction of the dysmenorrhea, anti-allergens, anti-malaria, anti-fever and for the jaundice. Dysmenorrhea means menstrual pain, which is not a disease, it is a condition by which women feel discomfort periodically in their menstrual cycle. There are two types of dysmenorrhea. In primary dysmenorrhea there is not any type of abnormality and in secondary dysmenorrhea gynecological problems which causes pain and cramps. The prevalence of the dysmenorrhea is 50-90% women suffer from these conditions respectively. Women have been used contemporary therapies to treat dysmenorrhea which includes herbal therapy (use of chamomile in form of tea and essential oil), physiotherapy, yoga and heat. Because in terms of treatment, such as non-steroidal anti-inflammatory drugs and oral contraceptives are not always effective in treating dysmenorrhea. So there is immerse need of herbal medicines such as chamomile in form of tea and oil to treat dysmenorrhea

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Comparison of the Effects of Matricaria chamomila (Chamomile) Extract and Mefenamic Acid on the Intensity of Mastalgia Associated With Premenstrual Syndrome

Cited by 3 publications

References 11 publications

Cyclic Mastalgia in Iranian Women: A Review

Cyclic Mastalgia in Iranian Women: A Review

Effectiveness of Matricaria chamomilla (chamomile) extract on pain control of cyclic mastalgia: a double-blind randomised controlled trial

Medicinal Properties of Chamomile against Dysmenorrhea

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