Comparison of the effects of 1 MHz and 3 MHz therapeutic ultrasound on endothelium-dependent vasodilation of humans: a randomised clinical trial

Hauck, Melina; Martins, Cássio; Moraes, Maicon Borges; Aikawa, Priscila; Paulitsch, Felipe da Silva; Plentz, Rodrigo Della Méa; Costa, Silvio Teixeira da; Silva, A.M. Vargas da; Signori, Luís Ulisses

doi:10.1016/j.physio.2017.08.010

Cited by 11 publications

(11 citation statements)

References 30 publications

(76 reference statements)

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“…30 Additionally, nonthermal, low-energy, pulsed low-intensity ultrasound treatments show non-significant clinical effects soft-tissue tendinopathy, 57 shoulder pathology, 17,58 and myofascial trigger point pain. 17,59 On the other end of the energy delivery spectrum, LICUS (0.132W/cm 2 , 3MHz, 100% duty cycle for 4 hrs, 18,720 Joules per treatment) provides mechanotransducive stimulation leading to tissue regeneration, the continuous nature of ultrasound signal provides increased localized temperature 33,34 of the tissue enhancing blood 35 and nutrient flow, oxygenation as well as reduction of inflammatory cytokines. 22,31 The LICUS treatment creates a 4°C heating increase in approximately 80 minutes when factoring for physiological cooling with participants at rest for multiple hours.…”

Section: Discussionmentioning

confidence: 99%

“…Self-applied wearable LICUS devices enable longer treatment durations, increasing energy deposition, 22 and accelerate healing. 22,31,32 LICUS produces ultrasound without pulses and increases muscle temperature, 33,34 creating a potential for increased blood flow, 35 increased connective tissue extensibility, 36,37 altered nerve conduction velocity, 38 and with less probability of forming adverse standing waves leading to potential tissue damage. Recent literature reviews on LICUS have found the treatment is effective in decreasing pain and improving function in musculoskeletal injuries.…”

Section: Introductionmentioning

confidence: 99%

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<p>Low-Intensity Continuous Ultrasound for the Symptomatic Treatment of Upper Shoulder and Neck Pain: A Randomized, Double-Blind Placebo-Controlled Clinical Trial</p>

Petterson¹,

Plancher

Klyve

et al. 2020

JPR

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Low-intensity continuous ultrasound (LICUS) is an emerging high-dosimetry ultrasound-based therapy for accelerated tissue healing and the treatment of myofascial pain. In this study, LICUS treatment is clinically evaluated for chronic upper neck and shoulder pain in a randomized, multi-site, double-blind, placebo-controlled study. Patients and Methods: CONSORT guidelines were followed in conducting and reporting the clinical trial. Thirty-three participants with upper trapezius myofascial pain were randomized for treatment with active (n=25) or placebo (n=8) devices. Investigators and subjects were blinded to treatment groups. Participants self-reported pain daily, rating from 0-10 on the numeric rating scale. If pain rating was more significant than or equal to 3, the LICUS (3MHz, 0.132W/cm 2 , 1.3W, 4 hours) was self-applied for total energy dosimetry of 18,720 Joules per treatment. During the 4-week study, daily pain rating was recorded. If LICUS treatment was delivered, pain before, during, and after treatment were recorded as well as the global rate of change (GROC). Independent t-tests were used to assess change from baseline and differences between treatment groups. ClinicalTrials.gov: NCT02135094. Results: There was a 100% completion rate for participants enrolled in the study and no significant differences between the groups regarding demographic variables or baseline outcome measures. Participants treated with active therapy observed a significant mean pain reduction from baseline of 2.61 points for active (p<0.001), compared to 1.58 points decrease from baseline for placebo (p=0.087), resulting in a 1.03 points significant decrease in the active group over placebo (p=0.003). The total GROC was significantly higher in the active group at 2.84 points compared to the placebo group at 0.46 points (p<0.001). Conclusion: Low-intensity continuous ultrasound treatment significantly reduced pain in patients with upper trapezius myofascial pain of the neck and shoulder. LICUS treatment showed a clinically meaningful improvement in the GROC scores for patients. The results from this clinical trial indicate that the LICUS treatment of 18,720 Joules can effectively be used to treat clinical pain related to upper trapezius myofascial pain. Further research could investigate varying dosimetry to improve efficacy and/or reduce the dose.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>Low-Intensity Continuous Ultrasound for the Symptomatic Treatment of Upper Shoulder and Neck Pain: A Randomized, Double-Blind Placebo-Controlled Clinical Trial</p>

Petterson¹,

Plancher

Klyve

et al. 2020

JPR

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“…The increase in blood flow produced by TUS is normally attributed to an increase in internal temperature due to the absorption of ultrasonic waves [ 15 , 17 , 18 ]. However, blood flow has also been shown to increase as a result of non-thermal effects associated with the mechanical forces producing the combination of cavitation and acoustic microstreaming effects, which may be related to NO production [ 3 , 16 , 19 ]. The thermal and mechanical effects occur simultaneously; however, the effects are dose-dependent on application parameters.…”

Section: Discussionmentioning

confidence: 99%

“…The increase in blood flow produced by TUS is normally attributed to an increase in internal temperature [ 15 , 17 , 18 ]. However, non-thermal TUS has also been shown to increase blood flow, which may be related to NO production [ 3 , 16 , 19 ]. In summary, the effects of TUS in endothelial-dependent blood flow are yet to be determined.…”

Section: Introductionmentioning

confidence: 99%

Effects of 1 MHz Therapeutic Ultrasound on Limb Blood Flow and Microvascular Reactivity: A Randomized Pilot Trial

Waters

Miljkovic

Rascon

et al. 2021

IJERPH

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A randomized, double-blind, placebo-controlled, cross-over study where continuous therapeutic ultrasound (CUS; at 0.4 W/cm2), pulsed therapeutic ultrasound (PUS; at 20% duty cycle, 0.08 W/cm2), both at 1 MHz, and placebo (equipment on, no energy provided) were randomized and applied over the forearm of the non-dominant arm for 5 min in 10 young, healthy individuals. Absolute and peak forearm blood flow (FBF) were measured via Venous Occlusion Plethysmography. FBF was measured before, halfway, and after (immediately and 5 min after) the therapeutic ultrasound (TUS) intervention. Post-ischemic peak FBF was measured 10 min before and 10 min after the TUS intervention. A two-way repeated measures ANOVA (group × time) was selected to assess differences in FBF before, during, and after TUS treatment, and for peak FBF before and after TUS treatment. FBF increased 5 min after TUS in CUS compared to placebo (2.96 ± 1.04 vs. 2.09 ± 0.63 mL/min/100 mL of tissue, p < 0.05). PUS resulted in the greatest increase in Peak FBF at 10 min after US (Δ = 3.96 ± 2.02 mL/min/100 mL of tissue, p = 0.06). CUS at 1 MHz was an effective treatment modality for increasing FBF up to 5 min after intervention, but PUS resulted in the greatest increase in peak FBF at 10 min after intervention.

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“…Such an excitation has been used previously for ultrasound imaging [30], [31]. The center frequency of the ultrasound transducer was 1 MHz, which is routinely used in biomedical applications [32], [33], and sufficient to resolve the tissue on length scales of few mm. To reduce the impedance mismatch between the sample and acoustic transducer, a coupling medium (Unictron's proprietary gel pad) was used.…”

Section: B Time-domain Ultrasound Attenuation Measurement Instrumentation (Td-uam)mentioning

confidence: 99%

Hybrid Spectral-IRDx: Near-IR and Ultrasound Attenuation System for Differentiating Breast Cancer From Adjacent Normal Tissue

Pal¹,

Nayak²,

Medisetti³

et al. 2021

IEEE Trans. Biomed. Eng.

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Objective: While performing surgical excision for breast cancer (lumpectomy), it is important to ensure a clear margin of normal tissue around the cancer to achieve complete resection. The current standard is histopathology; however, it is time-consuming and labour-intensive requiring skilled personnel. Method: We describe a Hybrid Spectral-IRDx -a combination of the previously reported Spectral-IRDx tool with multimodal ultrasound and NIR spectroscopy techniques. We show how this portable, cost-effective, minimal-contact tool could provide rapid diagnosis of cancer using formalin-fixed (FF) and deparaffinized (DP) breast biopsy tissues. Results: Using this new tool, measurements were performed on cancerous/fibroadenoma and its adjacent normal tissues from the same patients (N=14). The acoustic attenuation coefficient (α) and reduced scattering coefficient (µ's) (at 850, 940, and 1060 nm) for the cancerous/fibroadenoma tissues were reported to be higher compared to adjacent normal tissues, a basis of delineation. Comparing FF cancerous and adjacent normal tissue, the difference in µ's at 850 nm and 940 nm were statistically significant (p=3.17e-2 and 7.94e-3 respectively). The difference in α between the cancerous and adjacent normal tissues for DP and FF tissues were also statistically significant (p=2.85e-2 and 7.94e-3 respectively). Combining multimodal parameters α and µ's (at 940 nm) show highest statistical significance (p=6.72e-4) between FF cancerous/fibroadenoma and adjacent normal tissues. Conclusion: We show that Hybrid Spectral-IRDx can accurately delineate between cancerous and adjacent normal breast biopsy tissue. Significance: The results obtained establish the proof-ofprinciple and large-scale testing of this multimodal breast cancer diagnostic platform for core biopsy diagnosis.

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Comparison of the effects of 1 MHz and 3 MHz therapeutic ultrasound on endothelium-dependent vasodilation of humans: a randomised clinical trial

Cited by 11 publications

References 30 publications

<p>Low-Intensity Continuous Ultrasound for the Symptomatic Treatment of Upper Shoulder and Neck Pain: A Randomized, Double-Blind Placebo-Controlled Clinical Trial</p>

<p>Low-Intensity Continuous Ultrasound for the Symptomatic Treatment of Upper Shoulder and Neck Pain: A Randomized, Double-Blind Placebo-Controlled Clinical Trial</p>

Effects of 1 MHz Therapeutic Ultrasound on Limb Blood Flow and Microvascular Reactivity: A Randomized Pilot Trial

Hybrid Spectral-IRDx: Near-IR and Ultrasound Attenuation System for Differentiating Breast Cancer From Adjacent Normal Tissue

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