2012
DOI: 10.1159/000343406
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Abstract: Background: Plasma concentrations of natriuretic peptides are often elevated in chronic hemodialysis patients and difficult to interpret due to accumulation, high incidence of cardiac disease and changes in volume status. Mid-regional pro-ANP is a newly developed assay whereas BNP and its fragment NT-pro-BNP are available for a longer time. In this cross-sectional study, we compared the plasma concentration of MR-pro-ANP, BNP and NT-pro-BNP in stable ambulatory hemodialysis patients (n = 239) and investigated … Show more

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Cited by 15 publications
(12 citation statements)
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References 25 publications
(30 reference statements)
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“…Finally, we only assessed NTpro-BNP values and did not examine the association of other clinically available natriuretic peptides with dialysis-induced myocardial stunning. However, previous studies in patients with acute dyspnoea [21] and on chronic HD [8,9,15] found similar results for all tested natriuretic peptides. Therefore, our results should be generalizable to other natriuretic peptides.…”
Section: Discussionsupporting
confidence: 50%
See 1 more Smart Citation
“…Finally, we only assessed NTpro-BNP values and did not examine the association of other clinically available natriuretic peptides with dialysis-induced myocardial stunning. However, previous studies in patients with acute dyspnoea [21] and on chronic HD [8,9,15] found similar results for all tested natriuretic peptides. Therefore, our results should be generalizable to other natriuretic peptides.…”
Section: Discussionsupporting
confidence: 50%
“…Artunc et al [15] compared the potential of three clinically available natriuretic peptides (mid-regional pro-ANP, NTpro-BNP, BNP) to predict long-term all-cause mortality. They reported spot measurements of all three natriuretic peptides to possess a similar but only weak prognostic potential with areas under the receiver operating characteristic curve around 0.60.…”
Section: Discussionmentioning
confidence: 99%
“…In a previous study with this cohort, systolic left ventricular function estimated from echocardiography was the main determinant of the plasma concentration of cardiac biomarkers and also the strongest independent predictor of mortality [18,20]. Among cardiac biomarkers, troponin T and NT-pro-BNP revealed largely elevated plasma concentration due to accumulation as excretion was related to residual renal function in contrast to troponin I [18,19]. Along the same lines, the cut-off of troponin T and NT-pro-BNP derived from c-indices was higher than used for non-HD patients (Table 4).…”
Section: Discussionmentioning
confidence: 92%
“…These studies included high sensitive troponins T and I, natriuretic peptides (MR-pro-ANP, BNP, NT-pro-BNP), vasoactive peptides (copeptin, MR-pro-adrenomedullin, CT-pro-endothelin), FGF23 and alpha-Klotho [18,19,20,21]. With the current study, we wanted to find out, which of these biomarkers could qualify for risk prediction on a routine basis in asymptomatic hemodialysis patients.…”
Section: Introductionmentioning
confidence: 99%
“…This cohort was established between September 2009 and April 2010 to investigate the associations between novel biochemical risk parameters and mortality [12][13][14]. From a total of 250 eligible patients, 239 (96%) were enrolled.…”
Section: Baseline Characteristics and Outcomementioning
confidence: 99%