Comparison of the chronic unpredictable mild stress and the maternal separation in mice postpartum depression modeling

Zhang, Yan; Zhang, Li; Shi, Birui; Huang, Fulong; Gao, Yinhuang; Miao, Zhishuo; Ma, Keping; Zhan, Ziyao; Zou, Wei; Liu, Menghua

doi:10.1016/j.bbrc.2022.09.063

Cited by 8 publications

(8 citation statements)

References 31 publications

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“…We first validated that our CMUS protocol successfully altered postpartum behaviors relevant to PPD. In rodent studies, several groups report that exposure to gestational stress induces reduced gestational weight gain, anhedonia, reduced or disrupted maternal care, and passive coping in the forced swim test ( Haim et al, 2014 ; O'Mahony et al, 2006 ; Pardon et al, 2000 ; Smith et al, 2004 ; Zhang et al, 2022 ; Zoubovsky et al, 2020 ). Some report evidence of increased anxiety-like behavior ( Darnaudéry et al, 2004 ; Hillerer et al, 2011 ), while others observe no effect ( Leuner et al, 2014 ).…”

Section: Resultsmentioning

confidence: 99%

Gestational stress decreases postpartum mitochondrial respiration in the prefrontal cortex of female rats

Gorman-Sandler

Robertson

Crawford

et al. 2023

Neurobiology of Stress

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Section: Resultsmentioning

confidence: 99%

Gestational stress decreases postpartum mitochondrial respiration in the prefrontal cortex of female rats

Gorman-Sandler

Robertson

Crawford

et al. 2023

Neurobiology of Stress

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“…Compositionally, at the phylum level, a healthy gut microbiota is considered to have a low Firmicutes to Bacteroidetes ratio [79]. This ratio was unchanged by CUMS in mice on all three diets (see Supplementary Materials, Figure S3, however, mice on the HFD showed a higher abundance of Firmicutes and a lower abundance of Bacteroidetes compared to the AIN93M and SUP diets, suggesting that the HFD established a less healthy gut microbiota composition.…”

Section: Colonic Serotonin Synthesis and Metabolism Pathways Histopat...mentioning

confidence: 98%

“…Greater variability exists in the reported effects of chronic stress on the genera of the gut microbiota. A recent study by Zhang et al [79] compared the composition of the gut microbiota of mice in a CUMS model to those in a maternal separation model and found they were similar compositionally. However, they differed significantly in some specific relative abundances.…”

Section: Colonic Serotonin Synthesis and Metabolism Pathways Histopat...mentioning

confidence: 99%

The Effects of Chronic Unpredictable Mild Stress and Semi-Pure Diets on the Brain, Gut and Adrenal Medulla in C57BL6 Mice

Herselman,

Bobrovskaya

2023

IJMS

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Chronic stress is known to perturb serotonergic regulation in the brain, leading to mood, learning and memory impairments and increasing the risk of developing mood disorders. The influence of the gut microbiota on serotonergic regulation in the brain has received increased attention recently, justifying the investigation of the role of diet on the gut and the brain in mood disorders. Here, using a 4-week chronic unpredictable mild stress (CUMS) model in mice, we aimed to investigate the effects of a high-fat high-glycaemic index (HFD) and high-fibre fruit & vegetable “superfood” (SUP) modifications of a semi-pure AIN93M diet on behaviour, serotonin synthesis and metabolism pathway regulation in the brain and the gut, as well as the gut microbiota and the peripheral adrenal medullary system. CUMS induced anxiety-like behaviour, dysregulated the tryptophan and serotonin metabolic pathways in the hippocampus, prefrontal cortex, and colon, and altered the composition of the gut microbiota. CUMS reduced the catecholamine synthetic capacity of the adrenal glands. Differential effects were found in these parameters in the HFD and SUP diet. Thus, dietary modifications may profoundly affect the multiple dynamic systems involved in mood disorders.

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“…We first validated that our CMUS protocol successfully induced PPD-relevant behaviors. In rodent studies, several groups report that exposure to gestational stress induces reduced gestational weight gain, anhedonia, reduced or disrupted maternal care, and passive coping in the forced swim test (Haim et al, 2014; O’Mahony et al, 2006; Pardon et al, 2000; Smith et al, 2004; Zhang et al, 2022; Zoubovsky et al, 2020). Some report evidence of increased anxiety-like behavior (Darnaudéry et al, 2004; Hillerer et al, 2011), while others observe no effect (Leuner et al, 2014b).…”

Section: Resultsmentioning

confidence: 99%

Gestational stress decreases postpartum mitochondrial respiration in the prefrontal cortex of female rats

Gorman-Sandler

Robertson

Crawford

et al. 2022

Preprint

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Postpartum depression (PPD) is a major psychiatric complication of childbirth, affecting up to 20% of mothers, yet remains understudied. Mitochondria, dynamic organelles crucial for cell homeostasis and energy production, share links with many of the proposed mechanisms underlying PPD pathology. Brain mitochondrial function is affected by stress, a major risk factor for development of PPD, and is linked to anxiety-like and social behaviors. Considering the importance of mitochondria in regulating brain function and behavior, we hypothesized that mitochondrial dysfunction is associated with behavioral alterations in a chronic stress-induced rat model of PPD. Using a validated and translationally relevant chronic mild unpredictable stress paradigm during late gestation, we induced PPD-relevant behaviors in adult postpartum Wistar rats. In the mid-postpartum, we measured mitochondrial function in the prefrontal cortex (PFC) and nucleus accumbens (NAc) using high-resolution respirometry. We then measured protein expression of mitochondrial complex proteins and 4-hydroxynonenal (a marker of oxidative stress), and Th1/Th2 cytokine levels in PFC and plasma. We report novel findings that gestational stress decreased mitochondrial function in the PFC, but not the NAc of postpartum dams. However, in groups controlling for the effects of either stress or parity alone, no differences in mitochondrial respiration measured in either brain regions were observed compared to nulliparous controls. This decrease in PFC mitochondrial function in stressed dams was accompanied by negative behavioral consequences in the postpartum, complex-I specific deficits in protein expression, and increased Tumor Necrosis Factor alpha cytokine levels in plasma and PFC. Overall, we report an association between PFC mitochondrial respiration, PPD-relevant behaviors, and inflammation following gestational stress, highlighting a potential role for mitochondrial function in postpartum health.

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Comparison of the chronic unpredictable mild stress and the maternal separation in mice postpartum depression modeling

Cited by 8 publications

References 31 publications

Gestational stress decreases postpartum mitochondrial respiration in the prefrontal cortex of female rats

Gestational stress decreases postpartum mitochondrial respiration in the prefrontal cortex of female rats

The Effects of Chronic Unpredictable Mild Stress and Semi-Pure Diets on the Brain, Gut and Adrenal Medulla in C57BL6 Mice

Gestational stress decreases postpartum mitochondrial respiration in the prefrontal cortex of female rats

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