Comparison of the amount and patterns of late enhancement in Chagas disease according to the presence and type of ventricular tachycardia

Meléndez-Ramírez, Gabriela; Soto, Marí­a Elena; Alvarez, Leyli Claribel Velasquez; Meave, Aloha; Juárez-Orozco, Luis Eduardo; Guarner-Lans, Verónica; Morales, José Luís

doi:10.1111/jce.14015

Cited by 8 publications

(15 citation statements)

References 27 publications

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“…The combined analysis of studies reporting delayed enhancement in patients with the indeterminate form shows the occurrence of myocardial scar in 19% of the pooled population (Table 1). 9,10,[32][33][34][35][36][37][38][39] Myocardial fibrosis progressively increases with disease progression, being considered a marker of CCDC severity. 9 The higher the proportion of delayed enhancement in relation to the LV mass, the lower the ejection fraction of this chamber and the worse the estimated functional class.…”

Section: Myocardial Fibrosis and LV Systolic Dysfunctionmentioning

confidence: 99%

Untitled

2022

Arq Bras Cardiol: Imagem Cardiovasc

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My approach to Cirino et al. Echocardiographic Diagnosis of And Follow-up for Muscular Dystrophiesliterature is scarce on the use of new echocardiographic techniques such as myocardial strain in EDMD. Due to the high risk of conduction disorders, ventricular arrhythmias, and sudden cardiac death associated with EDMD, cardiac screening of first-degree relatives and asymptomatic carriers should be performed routinely. For the same reason, an implantable cardioverter-defibrillator should be considered for primary prevention in EDMD type 2. 17

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Section: Myocardial Fibrosis and LV Systolic Dysfunctionmentioning

confidence: 99%

Untitled

2022

Arq Bras Cardiol: Imagem Cardiovasc

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Section: Myocardial Fibrosis and LV Systolic Dysfunctionmentioning

confidence: 99%

Myocardial Involvement in Chagas Disease: From the Perspective of Cardiovascular Magnetic Ressonance Assessment

Moreira¹,

Volpe²,

Schmidt³

2022

Arq Bras Cardiol: Imagem Cardiovasc

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Chagas disease represents an important public health problem, especially in endemic countries in Latin America. Chronic cardiomyopathy is its most frequent clinical presentation. Myocardial involvement has a multifactorial pathogenesis and can lead to heart failure, thromboembolic events, arrhythmias, and sudden death. In this context, cardiovascular magnetic resonance imaging (CMR) is an excellent noninvasive method for investigating myocardial damage and understanding the mechanisms and consequences of these injuries. CMR has high spatial resolution and tissue characterization capacity, enabling a highly reliable morphofunctional analysis and the identification of risk markers for adverse events in patients with Chagas disease. This exam is very useful for the diagnosis and follow-up of these patients in the routine clinical setting.

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“…VA were investigated in three studies involving LGE. Two studies established that the involvement of two or more transmural segments was associated with a higher risk of ventricular tachycardia (VT) [6,9]. Mello et al [6] found that the group of patients with VT had a relative 4.1 risk (95% CI 1.06-15.68) of having two or more segments with LGE with a transmural distribution, compared to those without VT.…”

Section: Ventricular Arrhythmiasmentioning

confidence: 99%

Late Gadolinium Enhancement by Cardiac Magnetic Resonance and Speckle Tracking Echocardiography in the Evaluation of Cardiac Complications in Chagas Cardiomyopathy: A Systematic Review

Acero¹,

Ardila²,

Nanna³

et al. 2022

Rev. Cardiovasc. Med.

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Background: Chagas cardiomyopathy (CC) increases cardiovascular mortality associated with congestive heart failure (CHF), ventricular arrhythmias (VA), and sudden cardiac death (SCD). Different imaging techniques have been tested to assess disease progression and cardiac risk in individuals with Chagas disease (ChD). In this systematic review, we evaluated the accuracy in detecting cardiac complications in CC patients using cardiac magnetic resonance (CMR) and speckle tracking echocardiography (STE). Methods: A search was done on PubMed, Cochrane, and Embase for studies in humans over 18 years of age with ChD. Demographic data, research methodology, imaging parameters, and cardiac outcomes were extracted, and study quality was assessed, resulting in a narrative description. Results: Twelve studies with 1124 patients were analyzed. One study discovered a contractility pattern by STE. Four studies assessed the identification of Early Cardiac Impairment (ECI) and VA risk, respectively, while three studies evaluated the risk of SCD. Global Longitudinal Strain (GLS) identified patients with ECI (-18.5 ± 3.4% non-fibrosis vs -14.0 ± 5.8% fibrosis, p = 0.006 and -18 ± 2% non-fibrosis vs -15 ± 2% fibrosis, p = 0.004). The amount of fibrosis >11.78% or in two or more contiguous transmural segments were markers for VA risk. GLS and the amount of fibrosis were found to be predictors of SCD. Conclusions: STE may be considered a screening technique for identifying the subclinical status of CHF. CMR using Late Gadolinium Enhancement (LGE) is considered a relevant parameter for stratifying patients with ChD who are at risk of SCD. Fibrosis and GLS can be used as markers to categorize patients at risk for arrhythmias.

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Comparison of the amount and patterns of late enhancement in Chagas disease according to the presence and type of ventricular tachycardia

Cited by 8 publications

References 27 publications

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Untitled

Myocardial Involvement in Chagas Disease: From the Perspective of Cardiovascular Magnetic Ressonance Assessment

Late Gadolinium Enhancement by Cardiac Magnetic Resonance and Speckle Tracking Echocardiography in the Evaluation of Cardiac Complications in Chagas Cardiomyopathy: A Systematic Review

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